Posted by admin on Sep 30, 2018 in |
The objective of this study is to develop extended release matrix tablet of antihypertensive drug benidipine hydrochloride (BH) and to study its drug release pattern. BH has mean elimination half-life is ~3 h and requires dosing every 4 – 5 h in order to maintain optimal relief and is used orally in the management of hypertension and angina pectoris, but this frequent administration produces side effects like dizziness, headache. So in this study we have achieved to release drug for extended period of time up to more than 18 h for treatment of hypertension, for continuous 24 h control of blood pressure (BP), by taking polymers hydrophilic polymers, hypromellose (hydroxyl propyl methyl cellulose [HPMC] K100M), and polyacrylate polymers, eudragit RL100 and eudragit RS100 and also chitosan (CS) in order to find the suitable formulation. The tablets were prepared by direct compression method and also agglomerative phase of comminution (APOC). In-vitro drug release was carried out under simulated gastric and intestinal condition to achieve drug release. Fourier transform infrared spectroscopy...
Read More
Posted by admin on Sep 30, 2018 in |
The aspiration of the coeval cramming is connate with the entirety of second generation Super Porous Hydrogel Composites (SPHCs) with polyvinyl alcohol as a melded material. Conglomerates were unified by proving gas fanning approach. For coalescence, 50% Acrylamide solution (AM) and 50% Acrylic Acid solution (AA) were used as a monomer, 2.5% N, N’-methylene bisacrylamide (BIS) as a cross linker, 20% Ammonium Per Sulphate (APS) and 20% N, N, N’, N’- Tetramethylethylene Diamine (TEMED) as a polymerization assailant pair, 10% span 80 as a foam stabilizer were used. The gaffed super porous hydrogel’s were peg by inchoate enormity, computation of plausible density, porosity, bunion studies, void fraction, mechanical strength and surface morphology muse. In bifold distilled water, SPHCs trot out appalling accretion in their stasis bunion capacity. PVA revamp the bruise characteristics in twain the swelling media. SPHCs disport enriched mechanical clout as the concentration of polyvinyl alcohol is elevated. SEM images precisely marked the formation of interconnected pore, capillary channels, and the cross-linked polyvinyl alcohol molecules were espied...
Read More
Posted by admin on Sep 30, 2018 in |
The present study assayed the antifungal, larvicidal and antioxidant properties of the aqueous and acetone extracts of root and shoot of Biophytum sensitivum (Linn.) DC. The aqueous extracts of both root and shoot had little activity against the three test fungi such as A. niger, A. flavus and Penicillium. The acetone shoot extract was also ineffective against these fungi. However, the acetone root extract exhibited magnificent antifungal activity against A. flavus (zone of growth inhibition of 33.5 mm); but moderately affected the growth of Penicillium (9.5 mm), in the disc diffusion assay. The acetone root extract had no activity on A. flavus. The aqueous extracts of root and shoot of B. sensitivum were also assayed for larvicidal activity on the the 3rd and 4th instar mosquito larval stages. The shoot extract exhibited potent larvicidal activity, with 100% mortality induced in the larvae, within 48 h of exposure with the extract. The root extract on the contrary, had negligible activity against the mosquito larvae, exhibiting only 30% larvicidal activity, even...
Read More
Posted by admin on Sep 30, 2018 in |
Polymorphonuclear leukocytes or neutrophils are important components of host defense machinery. They are the first line of defense against invading microorganisms. In the present research work, ability of human neutrophils to phagocytose was studied in-vitro by exposing the polymorphonuclear leukocytes to Candida albicans and the phagocytic capacity was evaluated using aqueous extract of leaves powder of Putranjiva roxburghii Wall. The chemotactic activity that is the movement of polymorphonuclear leukocytes towards a chemical stimulant was studied in-vitro by placing polymorphonuclear leukocytes in presence of a chemotactic agent Zymosan using aqueous extract of leaves powder of Putranjiva roxburghii...
Read More
Posted by admin on Sep 30, 2018 in |
Background: Raktachandan / Pterocarpus santalinus is mentioned to have edema reducing property in Ayurvedic literature. Studies have been performed using its methanolic extract for anti-inflammatory, analgesic and antioxidant activities. Since, Ayurveda advises to use it as a decoction, we planned to study the acute anti-inflammatory activity of decoction prepared from Pterocarpus santalinus bark-wood powder. Methodology: Albino rats of either sex were divided into 4 groups of 6 rats each (Group I – Control (CMC-vehicle), Group II – Ibuprofen suspension, Group III – P. santalinus suspension 3.5 mg/kg, Group IV – P. santalinus suspension 7 mg/kg. All the experimental animals were given standard and test drugs orally, 45 min before inducing inflammation. Acute inflammation was induced by injecting 0.1ml of 1% carrageenan solution in sub-plantar tissue of left hind paw of the rats. Paw volume (Plethysmometer) and pain assessment (Randall and Selitto paw withdrawal method) were done at 0 h (before medication), then at 1 h, 2 h, 3 h and 4 h after induction of inflammation. Data was analysed...
Read More
