Posted by admin on Jun 30, 2024 in |
This study aims to enhance the therapeutic effectiveness of reserpine, an essential anti-hypertensive agent, by addressing its poor solubility and dissolution properties. Employing a Quality by Design (QbD) methodology, the research systematically optimized the formulation using solid dispersion technology and fast-dissolving films. Characterization of reserpine included its physical properties, such as melting point and partition coefficient, along with the establishment of a validated UV method for accurate quantification. The optimized solid dispersion (DRPSD14) achieved a theoretical solubility of 14.94% and dissolution of 96.88% at 20 minutes. Subsequently, a fast-dissolving film was developed from the optimized solid dispersion. Among twelve formulations, DRPSD14FDF11 exhibited promising characteristics, with 98.977±0.253% reserpine content. In-vitro dissolution studies demonstrated rapid dissolution for all formulations, with DRPSD14FDF11 displaying the highest dissolution rate. Release kinetics modeling and Fourier-transform infrared spectroscopy (FTIR) confirmed uniform drug distribution in the film, which also exhibited stability under various storage conditions. Guided by QbD principles, this comprehensive approach successfully optimized reserpine’s pharmaceutical properties, offering a promising formulation for hypertension treatment. The study provides...
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Posted by admin on Jun 30, 2024 in |
More attention on natural antimicrobials and antioxidants have increased. The medicinal plants production has high in Mediterranean region. WHO says many drugs can be obtained by using medicinal plants. Medicinal plants have many compounds of bioactive that gives more metabolic action on the human body. The congestive heart failure treatment and cardiac arrhythmia treatment can be treated by glycosides drugs. The glycosides have potent in curing many problems like cardiac insufficiency, coughs and circulatory problems. Glycosides acts as good sedatives and good antispasmodic properties. Saponins were found in Ligustrum sinense shows tendency for treating infections of fungal and yeast. The Ethyl acetate leaf mixed extract showed more effective of in phytochemical screening and against the tested microorganisms, Compare chloroform leaf...
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Posted by admin on Jun 30, 2024 in |
Ethnogynaecology is a young field of study that emphasize how indigenous people and local healers manage gynecological conditions in females. The goal of the current study was to record in-depth information about Ethnogynaecology in a previously unexplored region of Haryana. In the year 2022, a floristic and ethnomedicinal survey was conducted in Haryana, India in rural areas of Gurugram district. The present study identified forty plant species with twenty-seven families for treatment of various gynecological disorders. The most frequently used plant parts for herbal preparations were roots followed by leaves, fruit, bark, seed, whole plant, stem, buds, and bulb. The ethno-gynecological significance of medicinal plants in India provides a fertile ground for further scientific investigation to assess their potential, isolate bioactive compounds, and subsequently develop medications for the widespread gynecological health problems experienced by women...
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Posted by admin on Jun 30, 2024 in |
The increased use of antibiotics and the rise of antibiotic resistance among microorganisms pose significant public health concerns. While several herbal drugs have been validated for their antimicrobial activity, identification of additional antimicrobial agents is necessary. The Unani system of medicine comprises numerous herbs and formulations used for treating various infections. Arq e Ajeeb (AA) is one such formulation, historically utilized during epidemics to address conditions such as cholera (Haiza), tuberculosis (Sil), plague(Taoon), and seasonal fevers. Additionally, AA has been used as an anti-inflammatory and analgesic. This study aimed to evaluate the in-vitro antimicrobial activity of AA on four different bacteria, considering antibacterial properties demonstrated by its ingredients. The antibacterial activity of the test sample was evaluated using the minimum inhibitory concentration (MIC) method. Bacterial strains (P. aeruginosa, E. hirae, E. coli, S. mutans) were inoculated in 100μl sterile MHB broth. A test sample underwent double dilutions ranging from 100 to 0.048828mg. Ciprofloxacin (0.1%) served as the standard antibiotic. The plates were incubated at 32.5 ± 2.5°C for 24...
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Posted by admin on Jun 30, 2024 in |
This research investigates the anti-inflammatory potential of Azadirachta indica-loaded microsponges gel, presenting a novel therapeutic approach. The microsponges gel, formulated with Azadirachta indica, aim to enhance drug delivery efficiency for improved anti-inflammatory effects. The microsponges gel is formulated using Carbopol 934P (1% w/v) to optimized encapsulated microsponge. Prepared formulation was evaluated for pH, spreadability, viscosity, and ex-vivo drug deposition study. Characterization studies, in-vitro release assessments, and anti-inflammatory assays contribute to a comprehensive evaluation of the formulated microsponge gel. Preliminary results demonstrate successful formulation of Azadirachta indica-loaded microsponge gel. Characterization studies confirm the structure and composition. In-vitro release studies reveal sustained drug release, and initial anti-inflammatory assays indicate promising activity. This study underscores the potential of Azadirachta indica-loaded microsponge gel as a promising anti-inflammatory therapeutic strategy. The formulation’s sustained release profile and demonstrated efficacy in anti-inflammatory assays pave the way for further investigation and potential clinical...
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