Posted by admin on Sep 30, 2018 in |
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tween 80 and PEG 400 were selected as oil, surfactant and co-surfactant respectively. Liquid SMEDDS were characterized for self-micro emulsification time, droplet size, poly dispersity index, zeta potential, drug release, ex-vivo permeation. The optimized liquid SMEDDS formulation F16 contained capmul MCM (35%), tween 80 (55%), PEG 400 (10%). Formulation F16 has size of 13.66 nm, zeta potential-25.7 mV, drug release 78% in 8 h. The optimized liquid SMEDDS were converted into solid SMEDDS by adsorbing on to neusilin. The drug release was studied in 0.1N HCl and phosphate buffers pH 6.8 using dissolution apparatus II. The dissolution from liquid SMEDDS and solid SMEDDS was significantly high (P<0.0001) compared to drug...
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Posted by admin on Sep 30, 2018 in |
Objective: Guggulu is one of the important dravya (drug) used in Ayurvedic formulations since ancient time which means “Protection against diseases”. Ashuddha guggulu has physical and chemical impurities which need to be eliminated before using in formulation by shodhana. The present study was conducted to evaluate and compare the effect of different shodhana processes i.e. Samanya shodhana and Vishesh shodhana on properties of guggul by employing various physicochemical and chromatographic methods. Method: Physicochemical screening was done by evaluating ash, Acid Insoluble Ash (AIA), Loss on Drying (LOD), Water Soluble Extractive (WSE), Alcohol Soluble Extractive (ASE) and Ethyl acetate Soluble Extractive (EASE). Chromatographic analysis was performed to estimate guggulsterone (E and Z) content and to confirm the presence of ellagic acid and gallic acid, tinosporaside and diosgenin after shodhana with Triphala kwath, Gulvel kwath and Dashmool kwath respectively, using High Performance Thin Layer Chromatography (HPTLC). Result: The Physico-chemical studies showed decrease in LOD, Ash and AIA content and increase in extractive values such as ASE and EASE of guggul after...
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Posted by admin on Sep 30, 2018 in |
In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. The synthesized benzothiazole (BTA) derivatives were characterized physicochemically, by elemental analysis and spectral (IR and 1H-NMR) analysis. The synthesized compounds were screened for their in-vitro antifungal activity against Candida albicans, Aspergillus niger and Cryptococcus neoformans by cup plate method. The results revealed that three compounds namely BTA-3, BTA-9 and BTA-10 have better or equal antifungal activity compared to the standard fluconazole. Further research on benzothiazoles can warrant more consideration on benzothiazoles as prospective antifungal...
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Posted by admin on Sep 30, 2018 in |
Background: Salavana upanaha churna is a herbal compound drug consisting of Godhuma churna (Triticum aestivum L.), Rasna churna (Pluchea lanceolata (DC.) Oliv. & Hiern), Devadaru churna (Cedrus deodara (Roxb.) G.Don), Erandamoola churna (Ricinus communis L.), Vidanga churna (Embelia ribes Burm.f.), Vacha churna (Acorus calamus L.) and Saindhava lavana (rock salt) as main ingredients. Salavana upanaha churna is used extensively in management of spastic cerebral palsy in children. Aim: To standardize Salavana upanaha churna. Materials and Methods: Physico‐chemical studies like organoleptic characters, Powder microscopy, Loss on drying and HPTLC were carried out as per the WHO guidelines, Ayurvedic Pharmacopoeia and Indian Pharmacopoeia. Conclusion: Standardization tests done on Salavana upanaha churna helped in authenticating and ensuring the quality of the...
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Posted by admin on Sep 30, 2018 in |
Oxidative stress is involved in the pathogenesis of various degenerative diseases like cancer, inflammation etc. Thus, the study of antioxidant activity of natural molecules has remained a fertile ground for the researchers. In continuation of that effort, the present study was designed to evaluate the antioxidant, cytotoxic, antibacterial and anti-inflammatory potential of chloroform extract of Stereospermum chelonoides leaves (SCLC). Preliminary phytochemical analysis followed by total phenol and total flavonoid determination assays were carried out. Antioxidant potential was evaluated using DPPH radical scavenging assay, total antioxidant capacity, ferric reducing antioxidant power and cupric reducing antioxidant assays. Brine shrimp lethality bioassay and MTT based cytotoxicity assay was also conducted. Antibacterial assay was carried out using disc diffusion method on both gram-positive and gram-negative bacteria. Croton oil and xylene induced ear oedema models were used to determine anti-inflammatory activity. Phytochemical screening ensured the presence of various secondary metabolites notably polyphenols (38.04 ± 0.77 mg/g, GAE) and flavonoids (130 ± 7.86, mg/g, QE) which explained its dose dependent antioxidant activities. Moreover, cupric ion...
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