Posted by admin on Aug 31, 2018 in |
The aim of this present investigation is to identify the most important risk factor for cancer by means of a mathematical model. The study begins with considering some types of cancer viz. breast, colorectum as well as lung and bronchus cancer as most of the cancer patients suffer from these types of cancers. Teaching-Learning-Based Optimization technique is applied to sorting out the most lethal cancer among all cancer consider in this study and it is found that lung and bronchus cancer is the most fatal. Further, we investigate the risk factor associated to lung and bronchus cancer by means of Literature, Expert and Local Hospital survey. All the risk factor has their own importance for death from cancer in medical aspects. Multi-Criteria Decision Making technique is applied to recognize the most significant risk factor among all the factors in statistical scenario. It is identified that smoking is the most concerning risk factor. The information related from the study may help to take necessary measure to control the death rate...
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Posted by admin on Aug 31, 2018 in |
Introduction: Green leafy vegetables are known for their anti-alzheimer potential. There are many leafy vegetables, however, that have not been examined scientifically for this activity. The present study was designed to evaluate antioxidant and antiacetylcholinesterase activities of two Brassica species namely B. napus and B. oleracea var. acephala, along with the comparison of their pharmacognostic characters and phytochemical profiles. Methods: A comparative evaluation of macroscopy, microscopy, physico-chemical parameters and qualitative phytochemical screening was carried out on leaves of the selected plants as per Indian Pharmacopoeia. Further, a parallel analysis of antioxidant and anti-acetylcholinesterase activities of both species was done using DPPH and Ellman assay, respectively, followed by standardisation of the extracts on the basis of total phenol and total flavonoid content. Results: The hydromethanolic extract of B. oleracea var. acephala showed higher radical scavenging activity than that of B. napus. Similar results were obtained in case of total phenol content (B. oleracea var. acephala: 15.18 ± 1.82% w/w, B. napus: 12.69 ± 2.26% w/w). The hydromethanolic extract of B....
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Posted by admin on Aug 31, 2018 in |
From time immemorial pharmacologists and researchers have always been in search for novel drug screening methods. One such unique technique that is gripping the world by its leash is “human tissue chip technology”. This study explores the creation of Multiple Sclerosis (MS) using human tissue chip and assessing the ability of Vasicine a quinazoline alkaloid derived from Adhatoda Justiciae plant in reversing the inflammatory pathology of multiple sclerosis. 10 ml of human peripheral blood was withdrawn using a sterile syringe from a healthy donor. The blood was centrifuged to obtain mesenchymal stem cells (MSC). Then the MSCs were transferred with Dulbecco’s Modified Eagle’s medium (DMEM). After 48 h incubation, the MSCs were transferred into four flasks with growth factors and were seeded into tissue chip for differentiation into neuronal cells, cardiomyocytes, hepatocytes, and skeletal muscle cells. The respective cells were dislodged from tissue chip for histopathological evaluation and differentiation confirmation. Lipopolysaccharide (LPS) was added to these cells, to mimic MS inflammation and was confined to histo-pathological assessment. 9 biomarkers...
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Posted by admin on Aug 31, 2018 in |
Effervescent tablet is a convenient oral dosage form, which has special ingredients. This potency of effervescent tablet helps to delivered drugs, effectively. Medicinal plants have a wide range of usage in the world. Mespilus germanica (Rosaceae) and Quercus castaneifolia (Fagaceae) are important medicinal plants used in several diseases such as diarrhea. Medlar and oak, the fruits of M. germanica and Q. castaneifolia respectively, were harvested and extracted using hydro-acetonic solvent by maceration method. In addition, total phenol and tannin contents were assayed using Folin-Ciocalteu method. Antimicrobial activity of extract was determined using broth dilution test on some intestinal pathogens. Finally, effervescent tablets were prepared using wet granulation method and analyzed. Total phenols and tannins were obtained 0.9% and 0.1% respectively. This reduces the amounts of total tannins will disappear with adding antioxidant agents. Tablet hardness, friability and disintegration time were significantly dependent on the amounts of lubricant, acidifying and alkalizing agents. This work investigated the potential of developing Oak and Medlar effervescent tablets to facilitate drug administration and mask...
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Posted by admin on Aug 31, 2018 in |
We have developed Ag2Ga nanoneedles and achieved individual nanoneedles with diameter ranging from 200 to 250 nm with sharp tip and micro scale length required for a drug carrier to deliver drugs to site of application. Nanoneedles are designed to be inserted in human tissue and therefore they have to be compatible with the local environment of both in terms of toxicity and intended function. The variation of toxicity results for various nanostructures were reported in literatures. Hence, it is important to assess the information about toxicity of novel needle shaped nanostructures. Acute toxicity study was performed to examine the acute dermal toxicity of Ag2Ga nanoneedle mediated silver gel formulation on the rat’s skin, according to the OECD Guidelines Test no.402. Additionally, acute dermal irritation study was also performed to examine the irritancy potential following single, 1 h and 4 h, semi occluded application of Ag2Ga nanoneedle preparation on the rat’s skin according to OECD Guidelines Test no. 404. Acute toxicity study observations showed no skin toxicity or mortality...
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