Posted by admin on Aug 31, 2018 in |
The present study was conducted to investigate protective effect of hydro-methanolic (2:3) extract of leaf of Abroma augusta in streptozotocin induced diabetic male albino rat. For this purpose animals were divided into three treatment groups (n = 6): control group, STZ induced diabetic group (STZ 4 mg / 0.1 ml citrate buffer/ 100 g body weight), hydro-methanolic extract of leaf of Abroma augusta treated group (20 mg / 0.5 ml distilled water/100 g body weight). Treatment was conducted for 28 days. Blood glucose, serum insulin, glycated haemoglobin levels along with activities of hepatic carbohydrate metabolic enzymes, hexokinase and glucose-6-phosphate dehydrogenase were assed in all experimental groups. Oxidative stress markers like catalase, peroxidase enzyme activities, conjugated diene and thiobarbituric acid reactive substance levels in liver were measured. All these parameters were significantly recovered towards the control level after the treatment of hydro-methanolic extract. Pancreatic islet diameter, count of islet and number of cells in islets also decreased in diabetic animals. Treatment of these animals with extract resulted significant recovery towards...
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Posted by admin on Aug 31, 2018 in |
The whole plant of Cocculus pendulus (J.R. & G. Forst.) Diels is reported to have quality medicinal values in traditional system of medicines. The various physico-chemical parameters included determination of extractive value, loss on drying, ash values, fluorescence analysis, HPTLC analysis and preliminary phytochemical analysis were performed. The preliminary identification of Cocculus pendulus was observed by studying macroscopical features and the final authentication was confirmed by the botanist. Preliminary phytochemical analysis of whole plant of Cocculus pendulus revealed the presence of various phytoconstituents like alkaloids, carbohydrates, phytosterols, saponins, proteins and mucilage. HPTLC fingerprint analysis of ethanolic extract of plant Cocculus pendulus reveals presence of 13 peaks and 10 peaks in 256 nm and 366 nm respectively. The physico-chemical evaluation of Cocculus pendulus was a useful tool to identify quality, purity and authenticity of Cocculus...
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Posted by admin on Aug 31, 2018 in |
The present work aims to design, synthesize some novel benzimidazole derivatives and to perform in-vitro evaluation of their antitubercular and antimicrobial activity. In-silico modelling of benzimidazole derivatives was carried out using various softwares such as, ACD Labs Chemsketch, Molinspiration, PASS (Prediction of activity spectra for substances) and Schrodinger Glide XP (Grid based ligand docking with energetics). Nine derivatives (BI 1a, 1b, 1c, BI 2a, 2b, 2c and BI 3a, 3b, 3c) were designed. The designed molecules with required physicochemical properties, drug likeness and obeying Lipinski’s rule of five were selected for the synthesis. The synthesized compounds were subjected to TLC, melting point determination, FTIR and mass spectral studies. All the synthesized compounds showed characteristic peak in FTIR and Mass spectroscopic studies. As per the PASS score and GLIDE score the compounds were selected for biological studies like antitubercular, antibacterial, and antifungal activity. These results are useful for further investigation in the future. All the selected derivatives showed better activity, when compared with standard...
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Posted by admin on Aug 31, 2018 in |
Introduction: The ear, nose and throat (ENT) infections can be caused by a variety of microorganisms such as bacteria, fungi and viruses. Their treatment involves the use of appropriate antimicrobial agents and inappropriate use is closely linked to antibiotic resistance. Hence, present study was planned to evaluate the prescribing pattern of antimicrobials in the ENT outpatient department of a tertiary care teaching hospital. Materials and Methods: A cross-sectional, observational study was conducted from May 2016 to August 2016. Prescriptions of patients diagnosed with ENT infections were included. The information such as age, sex, type of ENT infections and drug data were noted in preformed case record form and evaluated. Results: Over 3 month study period, 512 prescriptions were analysed. Majority of the study population were in the age group of 21-40 years. Total numbers of males were 274 and females were 238. Among all, most common ear infection was chronic suppurative otitis media (17.19%). The commonest antimicrobial prescribed was Ciprofloxacin (29.18%) followed by Amoxicillin (25.38%). Only one antimicrobial was...
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Posted by admin on Aug 31, 2018 in |
Self-microemulsifying drug delivery system (SMEDDS) of Aceclofenac (ACE) was aimed at overcoming the problems of poor solubility. ACE is practically insoluble in water as a result it shows erratic oral absorption and affects the bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Labrafac PG 8 (20%) as oil, tween 80 (60%) as surfactant and Polyethylene glycol 400 (20%) as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, emulsification time and rheological determination. The optimized formulation exhibited 98.14 ± 0.34% in-vitro drug releases, which was significantly higher than that of the drug solution. The study confirmed the potential of ACE SMEDDS for oral administration. It was concluded that the SMEDDS formulation approach can be used to improve solubility and dissolution of poorly water-soluble drugs such as...
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