Posted by admin on Sep 30, 2018 in |
Benzosuberones and phenylpiperazinyl moieties are important heterocyclic compounds which constitute many biological activities which include anti bacterial, anti fungal, anti inflammatory, antioxidant, antitubercular and anti cancer activities. A novel series of 2,3-dimethyl-N-(3-(4-phenyl piperazin-1-yl)propyl)-6,7-dihydro-5H-benzo[7] annulene-8-carboxylic acids (5a-e) have been synthesized in good to excellent yields by experimental simplicity and milder reaction conditions and evaluated for their anti-proliferative activity. The titled compounds were identified and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. The novel derivatives synthesized were evaluated for in-vitro anti-proliferative activities on four different human cancer cell lines He La (cervical), MIAPACA (pancreatic), MDA-MB-231 (breast) and IMR32 (neuroblastoma) by sulphorhodamine B assay method. These synthesized novel derivatives which showed excellent anti-proliferative activity. The obtained results suggest that these classes of compounds can be considered as new hits for further structural optimization to obtain better anti-proliferative drug development...
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Posted by admin on Sep 30, 2018 in |
Studies to exploit wild mushrooms as a source of biologically active compounds are gaining importance in the recent years. In that view, the present study was carried out to evaluate the bioactives of wild edible macrofungi, Lentinus squarrosulus Mont. The specimen was subjected to various biochemical tests with the view to establish standards for their identity and chemical composition. To identify the chemical constituents the dried sporocarp was subjected to successive solvent extraction like petroleum ether, chloroform and ethanol using a Soxhlet extractor. The qualitative mycochemical analysis have shown the presence of some important chemical constituents viz., alkaloids, terpenoids, flavonoids, cardiac glycosides, steroids, phenols, fats and oils in all the extractives. Further, GC-MS analysis of ethanolic extracts was carried to identify the important volatile constituents. This data may provide baseline information about the bioactive constituents of these species in providing valuable compounds of substantial medicinal importance. The study also envisaged the proper identity of the target specimen by molecular identification. The present study illustrates the value of molecular tools,...
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Posted by admin on Sep 30, 2018 in |
Peptic ulcer is a condition associated with a number of factors involving excessive acid secretion in the stomach. This condition is difficult to control with single drug therapy and complete cure cannot be achieved. Even after discontinuation of the drug the relapse rate is high, and the long-term use of synthetic drugs produces adverse effects on the human body. The present study is expected to diminish millions of people suffering from ulcer in the country. This will not only provide them relief but will be safe enough from side effect as observed in allopathic medicines. So present study was to investigate gastro protective effect of selected Indian medicinal plant Trichosanthes dioica belonging to family: Cucurbitaceae. 50% ethanolic extract of Trichosanthes dioica fruit extract (TDE) was used for gastro protective effects on experimental models in rats. The entire drug solutions were prepared in 1% CMC solution and administered twice daily for five days or 10 days for prevention using three distinct animal models Model 1: Pylorus ligation + aspirin induced...
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Posted by admin on Sep 30, 2018 in |
The aim of the study is to investigate the capacity of pyrimidine derivatives like the active ingredient of Xymedon (I) and its derivative, salt-like conjugate with L–ascorbic acid (II) to stimulate liver recovery when damaged by toxic hepatitis. The study was done on out breed white rats. The liver damage was induced by carbon tetrachloride (injected 50% oil solution subcutaneously, once per day, 2-4 times, dose of solution 2 ml/kg). Tested compounds ((I), (II), Thiotriasolinum) were administered orally in the dose 20 mg/kg within 5 days. The new derivative (II) possesses pronounced hepatoprotective properties. It was established the obvious advantages of (II) in comparison with both Xymedon and Thiotriasolinum. Application of (II) improves of general medical condition of the animals (increase in the survival rate up to 100 %), the structure and morphology of their liver (reducing the symptoms of destructive, degenerative and irreversible changes to hepatocytes) and biochemical markers of cytolysis, synthetic and metabolic liver ability in blood (recovery in the levels of alanine-aminotransferase, aspartate-aminotransferase, γ-glutamyl-transpeptidase, total protein,...
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Posted by admin on Sep 30, 2018 in |
Terminalia catappa Linn. belongs to the family Combretraceae found in tropical regions of Asia, Africa and Australia, which is commonly called as Indian almond, sea-almond, tropical almond, wild badam. The fruit is useful in bronchitis and bowels. Juice of leaves is used in the preparation of the ointment for scabies, leprosy, cutaneous diseases and also as analgesic. The root bark is used in dysentery and diarrhoea. The stem bark cures fevers. The oil yielded from kernels is used commercially as a substituted for almond oil. According to the literature the different parts of the plants is used in many therapies including, antibacterial anticlastogenic, antioxidant, antifungal, antiulcer and molluscidal activity, management of sickle cell aneamia, anticancer, anti HIV reverse transcriptase, hepato- protective, anti-inflammatory, antidiabetic. In this study the methanol extracts of two varieties of Terminalia catappa (yellow and red variety) leaf was screened for antifungal like Candida albicans and Aspergillus niger and antibacterial like Eschiershea coli, Staphylococcus aureus, Citrobacter species, Enterococcus faecalis, Pseudomonas aerogenosa and Bacillus cereus was evaluated. The...
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