Posted by admin on Aug 31, 2018 in |
In order to effectively manage the diabetic mellitus type-II hyperglycemic surge, bilayered tablets comprising of gliclazide in immediate release layer (IRL) and metformin in sustained release layer (SRL) have been designed and fabricated for years. Gliclazide suffers from reduced aqueous solubility of 0.19 mg/mL which remained a crucial problem for the biological effect as a result of reduced dissolution and bioavailability. Therefore, in this research an effort was done to improve the aqueous solubility of gliclazide in a bilayer tablet by forming solid dispersions which will provide prompt release to completely manage the postprandial effectually. In this study, a bilayer tablet of gliclazide solid dispersion in IRL and metformin in SRL were fabricated by direct compression method, with an intention that the IRL of the formulation will release the gliclazide at its earliest to combat the postprandial hyperglycemic level followed by a control of steady state plasma glucose by sustained release metformin. The compatibility studies, pre-compression studies, post-compression studies, disintegration studies, dissolution studies, and kinetic release studies were performed....
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Posted by admin on Aug 31, 2018 in |
Aims and Objectives: To evaluate the current prescription pattern of drug utilization in patients admitted in cardiology intensive care unit (ICU) and to find out drug use indicators. Methods: It was a retrospective, observational hospital based study which was done for 6 months after obtaining permission from the institutional human ethics committee. The prescriptions of both genders and of any age groups suffering from any cardiovascular indication who were admitted in cardiology ICU were included. The parameters assessed were demographic profile of the patient, most common diagnosis, ICU outcome, number of days of ICU stay, most common group and number of drugs/prescription. Results: Data from 280 prescriptions were analyzed and it was found that 41-60 yrs patients were most commonly affected (53.6%), coronary artery disease (71.4%) is the most common indication. Most of the patients were discharged in improved condition (82.10%) with an average length of stay >5 days. Nitroglycerin (75.6%) is the most common drug used and at an average >12 drugs are used. Conclusion: Prescribing guideline is...
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Posted by admin on Aug 31, 2018 in |
Anxiety affects a large number of the population that creates an economic burden. Various traditional medicines like barbiturates, benzodiazepines and SSRI’s are used as anxiolytics but due to their potential to produce adverse effect on cognition limits their chronic use. Several homeopathic remedies are used for treating anxiety. For the first time this study was designed to determine anxiolytic activity of 30C Argentum nitricum. The remedy was compared with escitalopram. For this purpose several behavioral parameters were analyzed using head dip test, home cage activity, open field test and light and dark test. Distilled water, Argentum nitricum and escitalopram were administered orally to three groups of animals. The effects were recorded after 30th and 60th days of dosing. The results were compared statistically using one way ANOVA and Tuckey test was also being done for the multiple comparisons. The remedy highly significantly decreased the head dips and cage crossings after the 60th day of dosing (p ≤ 0.001). The central squares crossings in the open field apparatus was increased...
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Posted by admin on Aug 31, 2018 in |
The macro and micro nutrients content estimation was carried out for leaves of indigenous medicinal plant Murraya koenigii (L.) Sprenge collected from different places of North Karnataka region viz. Bidar, Kalaburagi, Shahapur, Sandur and Kappathgudda. About few kg of leaves of Murraya koenigii (L.) Sprenge plant material was collected and then they were washed in deionized water to eliminate contamination due to dust and environmental pollution. The washed leaves were air-dried under shade for more than a monthand then grinded to get fine powder. The powdered sample was heated at higher temperature to get ash. The obtained ash was digested with conc. HCl, deionized water and ash (25:25:1:950). The contents of macro, micro nutrients and harmful heavy meats such as K, Ca, Mg, Fe, Mo, Cu, Mn, Zn, Al, V, Cd and Ti were estimated by an analytical atomic absorption spectrometry technique. The experimental results confirmed the presences of mineral nutrients which are beneficial to the human body and are within the limit. The heavy metal which are harmful...
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Posted by admin on Aug 31, 2018 in |
The dry emulsion formulation aims to improve the solubility and dissolution of mefenamic acid. Dry emulsions are attractive because they are physically and micro biologically stable formulations. They represent a potential oral drug delivery system for lipophilic and low soluble drug substances. Dry emulsions can be prepared by spray drying, lyophilisation and rotary evaporation. Dry emulsion prepared here was by lyophilisation using capryol as the lipid phase and HPMC as the carrier. Mefenamic acid is the drug of choice which belongs to non-steroidal anti-inflammatory drug category. It is used as anti-pyretic, analgesic and anti-rheumatic and is used in the treatment of mild to moderate pain, including menstrual pain. The dry emulsion is formed by freeze drying method and incorporated in HPMC (hydroxyl propyl methyl cellulose) capsules, which provides a vegetarian environment and is a good alternative to gelatin. The formed dry emulsion formulation has been evaluated for the respective parameters in comparison with the marketed variant and the results are...
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