Posted by admin on Aug 31, 2018 in |
This manuscript presents the application of a detailed set of analytical technologies to the content of assorted micronutrient supplement and mineral supplement products on the market in the city of Concepcion, Chile. We applied TXRF as a screening technique for the evaluation of 1) The vitamin B-12 content in multivitamins and 2) the elemental composition (P, K, Ca, Mn, Cr, Fe, Cu and Zn) in mineral supplements. The analyzed 16 products (10 sold as pills, 3 as syrups, and 3 as solutions for intramuscular injections), were acquired directly from drugstores without medical prescription. They were processed in 3 different laboratories in order to avoid systematic errors. In the samples we evaluated: 1) The presence of the specified elements, 2) The correlation between the labelled contents and our evaluations; and 3) The possible presence of harmful elements for human health. In this study few anomalies were found: 1) in some products there are significant differences between the concentrations labelled and our evaluations. 2) The absence of cobalt in four of...
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Posted by admin on Aug 31, 2018 in |
Ionotropic gelation, a characteristic property, has become one of the easy, simple and mild ways of encapsulating variety of drugs, enzymes and proteins, prepared by various polysaccharides. The externally cross linked beads with calcium chloride and zinc chloride were suitable for water soluble and low molecular weight drugs. Insulin, encapsulated in a calcium pectinate gel beads by dispersing the insulin and core cross linking agent in a Solution of pectin, beads are prepared by dropping the dispersion in calcium chloride by inotropic gelation. The purpose of study was to improve the entrapment efficiency of high molecular weight drugs like insulin with internally cross-linking agents like calcium carbonate. Calcium pectinate beads containing insulin was prepared by surface cross linking with 1% and 5% w/v calcium chloride solution using calcium carbonate as internal gelling agent. Beads obtained using 1% w/v calcium chloride solution showed more drug entrapment than 5% calcium chloride solution. The core and surface cross linking of pectin beads improves drug loading by about 10 – 20% compared to...
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Posted by admin on Aug 31, 2018 in |
This research aimed to determine the antibacterial activity of methanolic, aqueous, chloroformic and petroleum ether extracts of Rubia tinctorum roots against two gram positive and two gram negative bacteria using agar well-diffusion method. The minimum inhibitory concentration (MIC) was determined using microdilution method. Extracts were dissolved in DMSO to obtain a concentration of 10% (w/v), and the density of bacterial suspension was 1.5 × 108 cfu/ml. Results showed that methanolic extract showed antibacterial activity against both gram negative and gram positive bacteria with minimum inhibitory concentration ranging from 0.1562 to 0.3125 mg/ml, while aqueous extract showed no activity against the tested bacteria. However, chloroformic extract showed antibacterial activity only against Escherichia coli with minimum inhibitory concentration value of 2.5 mg/ml. But petroleum ether extract showed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus with minimum inhibitory concentration ranging from 0.3125 to 1.25 mg/ml. But in conclusion, methanolic extract was the most effective against all tested bacteria. Further studies are needed for pharmaceutical...
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Posted by admin on Aug 1, 2018 in |
Sickle cell anemia is a hemoglobin disorder, which is an autosomal recessive type affects millions of children of underprivileged and tribal area every year. Because of its devastating complications sickle cell is considered a major health problem in India and the entire world. Since many years, majority of the tribal population in the South Gujarat region are suffering from this lifelong disorder, which is incurable till date. The study to clinically evaluate T-AYU-HMTM, a novel herbo-mineral preparation has been performed in patients with sickle cell anemia. The prior ethics approval for the study was obtained. This study was a non-randomized and efficacy comparative type study in which folic acid used as standard. The results were analyzed by using mean ± SEM and one-way analysis of variance. Results from the study show the drug is effective in alleviating the clinical symptoms of patients. Results showed drug is able to sustain the level of red blood corpuscle. The drug also sustained hemoglobin level by reducing sickle hemoglobin balancing it with raising...
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Posted by admin on Jul 31, 2018 in |
Nanobiotechnology in contemporary society is novel and has enhanced utility for size, distribution and morphology determination of various biomolecules. To prepare nano particles the used metals are gold, silver, mercury and platinum for significant applications in electronics, magnetics, optoelectronics and information storage. For our study we selected the sliver, since it is widely been used from ancient time for the treatment of bacteria, microbes, infections and serious burns as medicine or cosmetics and lotions in an emergence of new therapeutic agents. Plants are considered as environment friendly and efficient to produce in large-scale synthesis. So we selected the Trichodesma indicum for our study with combination of silver nitrate for silver ingredient in synthesis of silver nanoparticles (AgNPs) and their anti venom activity was studied. The properties of AgNPs of T. indicum were submitted to another journal had spherical particles of sizes 21 – 25 nm with active functional moieties of amino, carboxy, alcoholic and aromatics which contained the zeta potential of 30.9V. These properties of stem extract particles found...
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