Posted by admin on Oct 31, 2018 in |
Background: A Schiff base, a pharmacologically privileged scaffold and a nitrogen analog of an aldehyde or ketone in which the C=O group is replaced by C=N-R group. Mutual prodrug is a Carrier linked prodrug consist of two pharmacologically active substances together in a single moiety. Objective: The goal of the study is to synthesize combined form of the various Schiff’s bases with Naproxen for enhanced biological and pharmacological activity. Methods: Various conventional as well as green methods are incorporated for synthesis of Schiff’s bases whereas; simple shaking method is adapted for mutual prodrug synthesis. Biological evaluation was done according to literature. Results and Conclusion: Besides Naproxen’s important pharmacological activities, it possesses severe side effects due to certain functional groups present in it. Thus, derivatization method was incorporated to shun the side effects of the drug by synthesizing its Mutual prodrugs with Schiff bases having additional antibacterial...
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Posted by admin on Oct 31, 2018 in |
To investigate the effect of ethanolic extracts of leaf and fruit of Trichosanthe dioica (T. dioica) and leaf of Clitoria ternatea (C. ternatea) on the biochemical parameters in streptozotocin (STZ) induced diabetic Wistar albino rats. Healthy male adult Albino rats of Wistar strain were randomly divided into eleven groups of six rats each were assigned into normal and diabetic groups (Group I to XI). Diabetes was induced in albino rats by administration of STZ (60 mg/kg i.p). Group I and II were kept as normal control and diabetic control. The other diabetic groups from group III to group X were treated with either individual and combined ethanolic extracts of T. dioica and C. ternatea at a dose of 200 and 400 mg/kg of body weight (bw) were administrated at a single dose per day and group XI was treated with glibenclamide at a dose of 600 μg/kg body weight for 28 consecutive days. The effect of ethanolic extracts of leaf and fruit of T. dioica and leaf of C....
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Posted by admin on Oct 31, 2018 in |
Using inductively coupled plasma optical emission spectroscopy (ICP–OES) I determined the concentrations of heavy metals, arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd) and aluminum (Al) element after digestion using microwave pressure for 32 different types from the most popular and widely sold lipsticks in Riyadh markets. Analysis was conducted for the samples of expensive and cheap brand that advertise itself a natural (organic) and which advertise itself a medical. Samples of lipsticks from different countries were analyzed but with emphasis on China. I studied different concentrations of investigated elements with a different degree of color intensity, and gradation from the dark red to the light beige that shows the presence of significant differences in concentrations of the elements in the sample. The concentrations of investigated elements were also compared to the matte dry lipsticks and between the lipstick glosses and liquid lipsticks and between the lip glosses and the watery lip glosses and between white lip balm and the long lasting lipsticks. The results showed that only two...
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Posted by admin on Oct 31, 2018 in |
Chemotherapy and radiation are the most prescribed methods of cancer treatments but these are highly toxic and also are carcinogenic thus alternative cures are being explored especially on the use of cytotoxic substances isolated from natural sources like plants known for their ethnomedicinal properties. Natural chemopreventive agents such as antioxidants isolated from plants are argued to be important in suppressing or reversing carcinogenesis and to prevent the development of invasive cancers thus research studies are now currently geared in the evaluation and determination of the cytotoxicity and antioxidant activity of plant extracts to serve as ideal cure. Since the acquisition and processing of highly cytotoxic and selective effects of plant-based compounds to cancer cells are still limited, this study was conducted on eight plant species known to have folkloric medicinal properties. The leaf ethanolic extracts were examined for their antioxidant properties and cytotoxicity against Human Non-Small Cell Lung adenocarcinoma (A549), Human Colon Carcinoma Cells (HCT116) and Chinese Hamster Normal Ovary Cells (AA8). Antioxidant properties were observed to be high...
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Posted by admin on Oct 31, 2018 in |
The purpose of present study was to formulate the gastro-retentive floating microspheres of atazanavir sulfate to be retentive in the stomach for prolonged period of time. The gastro-retentive floating microspheres were prepared by double emulsion w1/o/w2 solvent evaporation technique and characterization for particle size, SEM, floating time, FTIR, DSC, and entrapment efficiency. The in-vitro drug release studies and in-vitro drug kinetics were performed for different formulations. FTIR and DSC studies revealed that the drug is compatible with excipients. The floating time of the floating microspheres was found to be > 12h. The particle size of all the formulations was evaluated by optical microscopy method. Formulation F1 – F4 comprising HPMC as rate retarding polymer exhibits an average particle size of about 515.25µm and microspheres F5 – F8 prepared with eudragit exhibit a mean particle of about 611.4 µm. Eudragit formulations exhibit an increased entrapment efficiency which is due to its large particle size and increased viscosity. All batches prepared show an initial burst release followed by sustained release. Formulation...
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