Posted by admin on Jul 31, 2018 in |
A series of, 2-thioxo-4-thiazolidinone (rhodanine) and 2,4-thiazolidine-dinone derivatives were synthesized by reacting 4-thiazolidine-dione/rhodanine moieties with 2-(4-formylphenoxy)-N-substituted-phenyl-acetamide, in equimolar proportions. The authentication of synthesized compounds was done by FTIR, 1HNMR, and mass spectrophotometry. The derivatives, N-(phenyl) -2- {4-[ (4-oxo-2-thioxo-1, 3-thiazolidin-5-ylidene) methyl]phenoxy}acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)-methyl]phenoxy}-N-(phenyl)-acetamide, were further screened for their anticancer properties against CEM cell lines. Cell viability was determined by trypan blue dye exclusion assay and cytotoxic effect of the compounds by MTT assay. The two derivatives, N-(phenyl)-2-{4-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy} acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)-methyl]phenoxy}-N-(phenyl)-acetamide were found to be anti-proliferative in nature at 75 – 100 μM and 100 – 250 μM concentrations, respectively. Thus, it can be established that the rhodanine derivatives, N-(phenyl) -2- {4- [(4-oxo- 2- thioxo-1, 3-thiazolidin-5-ylidene) methyl]- phenoxy}acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene) methyl] phenoxy}-N-(phenyl)-acetamide have anti-proliferative property against leukemic cell lines (lymphoblastic leukemia) and can be further optimized to improve its efficacy and...
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Posted by admin on Jul 31, 2018 in |
Traditional medicine and herbal formulations have been used by mankind for the cure and treatment of various diseases and disorders. Since time immemorable natural sources have been used as medicines by the humans. As per Indian System of medicine, Ayurveda, Siddha, Unani plants are formulated in various types of dosage forms like churna, gutika, asavas, aristasavlehas, etc. Various formulations with either Ayurvedic reference or as a household remedy or as a folklore medicine are commonly used. Balguti, Sitopaladi churn, Sootshekharmatra are few such traditional formulations which have been used commonly in various households. These formulations have immunomodulatory, expectorant and antacid properties respectively. Here in our studies we have reformulated these traditional formulations into new unit dosage forms. Considering the significance of patient compliance and market competition with modern dosage forms, present study involved phytochemical analysis of extracts used and their formulation of lozenges, jellies and dispersible tablets containing herbal ingredients. It was observed that, formulations were passing quality control tests. These formulations, being herbal would be with less side...
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Posted by admin on Jul 31, 2018 in |
The genus Litsea, is used in traditional and indigenous Indian and Chinese medicines for the treatment of diarrhoea, stomach ache, dyspepsia, gastroenteritis, diabetes, edema, arthritis etc. The objective of the present study was to evaluate the antidepressant activity of leaf and stem bark aqueous and ethanol extracts of L. floribunda (LF) as well as its interaction with conventional antidepressant drugs using Forced Swimming Test (FST) and Tail Suspension Test (TST) in mice. Albino mice were treated with extracts of L. floribunda (100 and 200 mg/kg, p.o.) and standard drug Imipramine (20 mg/kg, i.p.) for 14 days and after last dose administration on 14th day, all behavioural studies were performed and evaluated. The standard drug treated animals (20 mg/kg i.p.) evidently showed much less immobility time. Thus in FST model the antidepressant effect produced by group IV, group V, group VI, VII, VIII and X (100 and 200 mg/kg. p.o.) was comparable to that of group II i.e. standard drug Imipramine group where as in TST model, the antidepressant effect...
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Posted by admin on Jul 31, 2018 in |
Introduction: Early treatment in growing patient is of value as the guidance of occlusion to normalcy can shorten the treatment time in mature patients. The removable appliance is commonly used by pediatric dentist to intercept malocclusion in such patients, but it brings a major drawback with it of being compliance dependent. Fixed appliance therapy is better accepted and has better wear compliance in young patients. One such fixed appliance proven to be successful when given in mixed dentition is a quad helix. Modified quad helix can prove to be a very versatile appliance. This case report discusses the advantage, mode of action and effects obtained by novel modification of quad helix. This appliance was chosen to achieve slow maxillary expansion and also to gain space for labially placed tooth simultaneously. Clinical Significance: Quad helix being a multifaceted appliance, this neoteric appliance design could be of help for pediatric dentists in treating such similar...
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Posted by admin on Jul 31, 2018 in |
Triple negative breast cancer (TNBC) is a type of breast cancer in which receptors such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are absent. Triple-negative breast cancer is a high risk breast cancer that lacks the benefit of specific therapy that targets these receptors. In the present study, anethole an aromatic compound from star anise was exposed to TNBC cell line MDA-MB-231 to assess its anticancer property. Cytotoxicity assay was done to determine and optimize the dose. DNA damage was analyzed by DNA fragmentation method. The use of targeted agents against TNBC such as poly-ADP-ribose and insulin like growth factor receptor were investigated in the present study. The drug-target interaction was investigated using in-silico docking studies. The in-silico study provides evidence for the interaction of anethole with the target proteins namely poly ADP-ribose polymerase (PARP) and insulin like growth factor receptor (IGFIR). This interaction is presumably vital in exerting the anticancerous activity. The present study clearly elucidates that anethole possesses anticancer activity against the...
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