Posted by admin on Oct 31, 2018 in |
Background: WHO statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of 9 million thus making India accountable for almost one-third of the global TB burden. The first-line antitubercular drugs include H (Isoniazid), R (Rifampicin), Z (Pyrazinamide), E (Ethambutol) and S (Streptomycin). The treatment of tuberculosis being of longer duration being a multidrug regime and of longer duration gets associated with various adverse effects. Objective: The study aimed to determine the incidence and pattern of adverse drug reactions (ADRs) of anti-tubercular drugs in tuberculosis patients treated under DOTS at tertiary care hospital of Northern India. Material and Method: A total of 115 patients were monitored for the period of 12 months. The diagnosis of tuberculosis was confirmed by sputum smear prior to enrolment. Before the patients were started on DOTS regimen, they were submitted to some pretreatment investigation and then they have been followed up to look for any adverse effects which have been recorded onto the...
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Posted by admin on Oct 31, 2018 in |
A series of N-mustard substituted coumarin have been synthesized characterized and evaluated for their in-vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-2-oxo-2H-chromene-3-carbonitrile derivatives. Among these compounds screened, three compounds (ASW-3g, ASW-3f and ASW-3e) showed GI50 range from 80 to 95 µg/ml. All synthesized compounds were characterized by IR, NMR and Mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer...
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Posted by admin on Sep 30, 2018 in |
This study was planned to evaluate the anti-inflammatory effect of roots of Asparagus curillus in periodontal inflammation via assessing gingival crevicular fluid (GCF) and salivary inflammatory markers namely MMP-8, -9, 13, TIMP-1 and IL-6. Samples of GCF and saliva were obtained from patients with chronic periodontitis (n = 98) and healthy controls (n = 27). Study population (n = 98) was divided into two groups – Group A: patients with periodontitis receiving only conservative periodontal treatment and Group B: patients with periodontitis receiving both the conservative periodontal treatment and Ayurvedic therapy in combination. Concentrations of periodontal inflammatory markers i.e. MMP-8, -9,-13, TIMP-1 and IL-6 were estimated by Enzyme linked immuno absorbent assay and were analysed at two different time intervals i.e. at baseline and 3 months after therapy. There was statistically significant decrease in the concentrations of MMP-8, -9, -13 in GCF and saliva in both the groups at 3 months after therapy. (p < 0.05) However, there was found a statistically significant lower concentration of the markers in...
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Posted by admin on Sep 30, 2018 in |
Urinary tract infections (UTIs) are the most common infections of pregnancy and pose great therapeutic challenges. The objective of the present study was to evaluate and compare the antimicrobial treatment practices for UTIs during pregnancy in comparison with the standard treatment guidelines. A prospective cross sectional study was conducted on 782 pregnant female patients suffering from UTIs in hospitals of Wah Cantt, District Rawalpindi, Pakistan. Prescriptions and available laboratory test reports including complete blood count (CBC) from each patient was taken. Statistical tests One Way ANOVA and chi-square tests (P≤0.05) were performed to obtain the desired outcomes. It was evaluated that none of the clinical setting have developed its own antibiogram or local antibiotic use guidelines. Standard management guidelines for antimicrobial therapy for UTI in pregnancy were followed in only 16.7% patients. Moreover only two drugs from the standard management guidelines were prescribed to the patients. It was determined that statistically significant population (p<0.05) were being prescribed with the drugs not recommended by any guidelines. 26.9% patients were being...
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Posted by admin on Sep 30, 2018 in |
A topological index is a numeric quantity from the structural graph of a molecule. It has become a very useful tool in the prediction of pharmacological, toxicological and physico – chemical properties of a compound. In this paper, we have computed some topological indices of triangular silicate TsL (n) and triangular oxide TOL (n)...
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