Posted by admin on Jul 31, 2018 in |
This study was conducted to evaluate the clinical usefulness of new developed kit of 99mTc-TRODAT-1 to differentiate PD(Parkinson disease) from volunteer subjects. The 925-1111MBq (25-30 mCi) 99mTc-TRODAT-1 samples were reconstituted by boiling water bath method. Fourteen subjects (women = 6, men = 8, age range 24 – 72, mean = 54.4) have been participated in this approach. The control group included (women = 2, men = 2, age = 25-70, mean = 54.75) and the other group included 10 PD patients (women = 4, men = 6, age = 42-72, mean = 54.1) the different stages of PD. Hoehin and Yahr Scale criteria was chosen for clinical evaluation of PD patients. Brain SPECT study has been performed using a single-headed gamma camera 3 hours post intravenous injection. Visual inspection of radiotracer uptake in the striatum and semi-quantitative analyses were performed. The radio-HPLC analysis indicated that the 99mTc-TRODAT-1 samples were successfully prepared with a radiochemical purity over 90 %. Semi-quantitative analysis demonstrated that the negative relation between the striatal uptake...
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Posted by admin on Jul 31, 2018 in |
The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. Different extracts of the rhizomes of Tectaria cicutaria were subjected to phytochemical analysis, anti-microbial activity and in-vitro anticancer activity. The in-vitro anticancer activity was performed using Sulforhodamine B (SRB) assay against various cancer cell lines namely Human Leukemia Cell Line (K562), Human Nasopharyngeal Cancer Cell Line (KB), Human Colon Cancer Cell Line (HT29) and Human Colon Cancer Cell Line (Colo205). Phytochemical analysis confirmed the presence of bioactive compounds. The total phenolic contents (TPC) and total flavonoid contents (TFC) of ethanolic extract was found significantly higher and showed antimicrobial activity against Proteus vulgaris. Out of the various extracts and cell lines used for studying anticancer activity, the ethanolic extract showed excellent anticancer activity against Human Leukemia Cell Line (K562) with GI50 value 11.9 µg/ml. The present work has for the first time, tried to elucidate the activity of different extracts of Tectaria cicutaria on human cancer cell...
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Posted by admin on Jul 31, 2018 in |
The objective of the study was to fabricate protein nanoparticles for better controlled and targeting action of drug, which can also overcome the problems like multidose therapy, poor patient compliance and high cost associated with conventional formulations. Memantine HCl loaded casein nanoparticles (F1 to F6) were prepared by ionically cross-linked method. The formulated nanoparticles were evaluated for external morphological characters, determination of particle size analysis, zeta potential, drug content, entrapment efficiency and in-vitro release studies. The particle size varied from 148 to 317 nm and zeta potential was in negative and its value found to be – 46.4 mV. The drug content for the Memantine HCl loaded casein nanoparticles varied from 69.5 ± 7.2% to 87.9 ± 1.2%. The entrapment efficiencies were found to be minimum and maximum of 55.50 ± 2.4% and 86.30 ± 3.6%. The percentage yields of all formulations were in the range of 48.24 ± 1.24 to 86.13 ± 1.37%. In-vitro release of drug follows zero order and showed sustained release behaviour for a period...
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Posted by admin on Jul 31, 2018 in |
Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon for which a lot of treatment modalities are present, however, significant side effects are associated with them and there is a need for a search for other treatment options. This study was aimed to investigate the therapeutic role of Doxycycline in experimentally induced colitis in rats. Animals were categorized into 5 groups; the control group undergoes no induction of UC, colitis group in which UC was induced and animals receive no treatment, the Doxycycline group that received Doxycycline and Sulfasalazine group that received Sulfasalazine. Each group was composed of 10 animals. After the completion of the one-month period of experiment, animals were sacrificed and the following measures were done: weight of colon, determination of the area of mucosal damage by mm2, histological scoring after hematoxylin and eosin stain together with MAC score and immunohistochemistry of IL-6, TNF-alpha, MPO, MDA, CD62, and ICAM1. The results revealed that Doxycycline was able to reduce the area of mucosal damage, colon weight,...
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Posted by admin on Jul 31, 2018 in |
The main aim of the study was to formulate the buccal films of most satisfactory formulation by in-vitro evaluation. The present investigation was done to formulate Hydralazine hydrochloride with an objective to improve therapeutic efficacy, Patient compliance. Hydralazine hydrochloride buccal films were developed by solvent casting method. Formulation H2, P4, S8, was best fitted to the in-vitro release studies and zero order release was...
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