Posted by admin on Sep 30, 2018 in |
Lamium album is used as a blood purifier, in the treatment of the respiratory tract diseases, diarrhea and bleeding. In this study antioxidants and anti-bacterial activities of its aerial parts and roots were investigated. Extracts were prepared by Soxhlet apparatus. Methanol used as extracting solvent. Phenol and flavonoids contents and antioxidant properties were evaluated by different methods. Different concentrations of extracts were used for determining the MIC. Microorganisms suspensions were prepared in Mueller Hinton broth with different concentrations of extracts and incubated for 24 h at 37 °C, the turbidity of the tubes were observed. MIC and MBC were determined. Total phenolic content of aerial and roots extracts were 242.75 ± 10.13 and 135.0 ± 8.15 and total flavonoid contents were 79.83 ± 4.22 and 30.33 ± 1.08 QE respectively. The DPPH radical-scavenging ability of extracts were 238.4 and 257.0 µg/ml respectively. Reducing power of both extracts increased by increasing the concentrations. The amount of scavenging nitric oxide at the 1600 mg/ml, was 58 and 68%, respectively. IC50 for...
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Posted by admin on Sep 30, 2018 in |
Ageing is associated with the diminished function of various tissues in the body. The gonadal function declines with age. In male, there is progressive atrophy of the sperm producing elements of the testes, resulting in diminished spermatogenesis. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium suffruticosum (Is) in improving the fertility of senility induced sterility of male albino rats. A total of 24 healthy young male albino rats were selected and six animals were randomly distributed into 4 groups. The groups include normal control, positive control, experimental I and Experimental II. Normal control was administered sterile water orally; positive control was administered testosterone hormone subcutaneously (10 µg/kg body weight), experimental I group was administered ethanolic extract of Cycas circinalis (200 mg/kg body weight) and Experimental II group was administered ethanolic extract of Ionidium suffruticosum (200 mg/kg body weight) orally for 30 days. Various parameters such as sexual behaviour, weight of animals,...
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Posted by admin on Sep 30, 2018 in |
A new drug delivery system for H2 receptor antagonist ranitidine hydrochloride was developed utilizing both the concepts of adhesiveness and of flotation, in order to obtain a unique drug delivery system which could remain in the stomach for a much longer period of time. Floating mucoadhesive tablets of ranitidine hydrochloride were developed to prolong its release and improve bioavailability. Ranitidine has been the most widely used drug for the treatment of peptic ulcer. A Floating Drug Delivery System (FDDS) was developed using gas forming agents like sodium bicarbonate, citric acid and hydrocolloids, Hydroxyl Propyl Methylcellulose (HPMC) and carbopol 934P. Floating delivery system of ranitidine hydrochloride was prepared using different grades of HPMC as drug release retarding polymer and sodium bicarbonate as source for carbon dioxide which helps tablets to float. Tablets were prepared by direct compression. The prepared tablets were evaluated their physicochemical properties and drug release, density, buoyancy test, mucoadhesion force, swelling study, drug content and in–vitro release...
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Posted by admin on Sep 30, 2018 in |
The aim of this study was to investigate the phytochemical constituents and therapeutic potential of various solvent extracts of Mallotus roxburghianus both in-vitro and in-vivo. Free radicals scavenging activities of various extracts were determined in a cell free system and the hepatoprotective effects was investigated in doxorubicin induced oxidative stress in Swiss Albino mice by estimating various antioxidant activities using standard methodology. Different extracts of M. roxburghianus inhibited the generation of ABTS (2, 2’-azino-bis-(3- ethylbenzothiazoline- 6- sulfonic acid), DPPH (1, 1-diphenyl-2-picryl-hydrazyl) and superoxide anions in a concentration dependent manner and the aqueous extract showed the highest scavenging activities with IC50 of 87.38 ± 0.69 μg/ml, 3.24 ± 0.21 μg/ml and 92.65 ± 1.18 μg/ml for ABTS, DPPH and superoxide radicals, respectively. Phytochemical analysis revealed that aqueous extract possessed the highest phenolic (347.6 ± 2.9 mg GAE/g dry extract) and flavonoid (68.80 ± 0.11 mg quercetin/g dry extract) contents. The free radicals scavenging activity was significantly correlated with phenolic (r2 = 1.00; p<0.001) and flavonoid (r2 = 1.00; p<0.001) contents...
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Posted by admin on Sep 30, 2018 in |
Synthesis and anti-mycobacterial activity of some novel derivatives of anacardic acid viz., 2-Ethoxy-6-pentadecyl benzamide (APHK-1), 1-(2-methoxy-6-pentadecylbenzyl)-4-hydroxy ethylpiperazine (APHK-2), 1- (2-hydroxy-6-pentadecyl)- N- (hydroxyl ethylaminoethyl) benzamide (APHK-3) and compounds 20-34 from saturated anacardic acid which was obtained from natural product cashew nut shell liquid (CNSL) is reported. Anti-mycobacterial activity was performed using Mycobaterium smegmatis mc2 155, taking anacardic acid and ethambutol as standards. Of all the derivatives, 1-(2-hydroxy-6-pentadecyl)-N-(hydroxyethylaminoethyl) benzamide exhibited good anti-mycobacterial...
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