Posted by admin on Jul 31, 2018 in |
The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Piperacillin (Pip) with potassium hydrogen peroxo-monosulfate in alkaline medium is studied by the increase of forming product light absorbance. A scheme of peroxoacid oxidation and perhydrolysis conjugated reactions of Piperacillin by means of hydrogen peroxomonosulfate is proposed. The procedure of the quantitative analysis of Piperacillin in the combined with Tazobactam pharmaceutical preparation powder of Zopercin® (Piperacillin 4.0 g and Tazobactam 0.5 g) by spectrophotometric – kinetic method is elaborated using triple potassium Caro’s salt solution as a reagent. Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙ K2SO4 (Oxone®) of “extra pure” qualification was used as oxidant. At pH 2-4 for 1 mole of Penicillin, 1 mole of KHSO5 is consumed; the quantitative interaction is achieved within a time of more than 1 min (observation time). The method on initial rates (tangent method) was used to collect kinetic data (usually at 280 nm) by following the appearance product of perhydrolysis reaction of Piperacillin. A solution of sodium hydroxide was thermostated in...
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Posted by admin on Jul 31, 2018 in |
The aim of the present work is to develop the formulation the orodispersible tablets of Serotonin hydrochloride. The tablets were prepared by direct compression technique using microcrystalline cellulose (MCC) as directly compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG) and Crospovidone were used. Method: Using different concentrations of superdisintegrants seven formulations were made and further investigated. The prepared powder mixtures were subjected to both preformulation and physical evaluation studies, and further post compression evaluation parameters including tablet hardness, friability, disintegration time and in-vitro drug release. Results: The pre-compression studies revealed that all formulations were found to be of good flowability. Tablet hardness and friability revealed good mechanical strength. Conclusion: After evaluating all the formulations it has been revealed that the tablets exhibited acceptable properties. According to the present study, it was found that tablets of batch F4 (blend containing CCS & crospovidone (15mg) showed better disintegrating property as well as % drug release (98.78% within 40...
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Posted by admin on Jul 31, 2018 in |
Boerhaavia diffusa is a natural herb possesses potent diuretic, anticancer and antioxidation properties. This work was designed to investigate the effect of hydro alcoholic extract of Boerhaavia diffusa Linn. on hepatoprotective efficacy in D-galactosamine-intoxication in mice. Albino Mice divided into 5 groups each consisting of 6 animals. Group 1 served as vehicle control, Group 2 served as hepatotoxin (D-Galactosamine treated) group, Group 3 served as positive control (Vitamin-E) treated group, Group 4, 5 served as treatment control (200 and 400 mg/kg b.w p.o.) HAEBD. Treatment given for 8 days and D-Gal on last day for all the groups except normal control. D-galactosamine-induced toxicity was manifested by the elevation of serum hepatic marker enzyme activities (Aspartate amino transferase, Alanine amino transferase, alkaline phosphatase and gamma-glutamyl transpeptidase). It also caused significant lipid peroxidation and reduced the levels of antioxidant defense mechanisms. Treatment with HAEBD (200 and 400 mg/kg body weight) orally for 8 days decreased hepatic marker enzyme activities and lipid peroxidation products, lipid hydroperoxides and conjugated dienes, increased the activities...
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Posted by admin on Jul 31, 2018 in |
Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin, followed by ring opening reaction of epoxy positioned at 1st and 2nd carbon in the chemical structure. It was characterized by NMR, seven -CH2 (position 10, 11, 9, 8, 6, 4 and 2) carbons present at negative side. Tertiary carbons are present at chemical shifts 39 ppm and 70 ppm (position at 7 and 3) and primary carbons are present at chemical shifts 10 ppm and 13 ppm (position at 14 and 12). Both primary and tertiary carbons were found on the positive side of the spectrum. From FTIR studies, peak corresponding to -OH stretch is observed at 3,391 cm-1 and the -OH bending is seen at 1,111...
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Posted by admin on Jul 31, 2018 in |
The sublingual delivery of drugs represents a continuing challenge, as well as an opportunity. In this study, a poly (lactic-co-glycolic acid) (PLGA) based Water-in-Oil-in-Water (w/o/w) double emulsion of nanoparticles was developed as potential platform technology, to generate sustained drug release profile and maximize the bioavailability of the glutathione (GSH). Two-level full factorial design was carried out based on different types and concentrations of the stabilizers used, and on varying sonication time. The optimal formulations were predicted with particle size of 232.57 ± 20.56 nm, zeta-potential of -12.33 ± 0.20 mV and entrapment efficiency of 77.04 ± 1.50%. Spherical particle morphology and uniform size was observed by scanning electron microscopy. Sustained release profile was achieved and the release kinetics was illustrated as a Korsmeyer – Peppas kinetic model. Moreover, in ex-vivo permeation studies, approximately 2-fold increase in the transmucosal permeation of GSH was achieved when PVA and carbopol were incorporated with the nanoparticulate delivery system, resulting in 21.9 ± 1.2% drug permeation and a permeation coefficient of (4.96 ± 0.36)...
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