Posted by admin on Mar 31, 2024 in |
The study focuses on creating and evaluating a specialized bilayer tablet for treating hypertension. It begins with in-depth preformulation analyses of key components like Atenolol, Hydrochlorothiazide, and various excipients. Special emphasis is placed on optimizing the powder blend’s flow properties to facilitate tablet compression. A series of tests on resulting tablets (F1 to F8) assess weight variation, thickness, hardness, friability, disintegration time, and drug content, ensuring they meet required specifications with uniform weight and hardness. Dissolution profiles of all formulations are examined, with Formulation 8 (F8) identified as the most suitable for consistent drug release across both layers. The study investigates drug release mechanisms, finding that both layers adhere to the diffusion-controlled release model, particularly the Higuchi model. Stability tests conducted under elevated temperature and humidity (40°C/75% RH) over three months reveal minimal changes in physical attributes, drug content, and drug release profiles, confirming the tablet’s stability. In conclusion, the study successfully develops an optimized Immediate Release Bilayer Tablet containing Atenolol and Hydrochlorothiazide. This tablet offers controlled and uniform...
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Posted by admin on Mar 31, 2024 in |
Moringa oleifera leaves, have a high antioxidant content, which is beneficial for overcoming free radicals in the body. The leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate were used as effervescent agents because they both provide acceptable texture and mouth feel. This study aimed to develop an effervescent granules formulation of Moringa oleifera leaf extract and to optimize the molar ratio of citricacid and sodium bicarbonate as the effervescent agent. Three formulations using different ratios of citric acid and sodium bicarbonate were selected, namely F1, F2 and F3. These formulations were developed using the wet granulation method. The results showed by effervescent granules of the three formulations exhibited good flow ability and good particle size distribution. The organoleptic and sensory evaluation results showed formulation F3 was the most acceptable in terms of colour, taste,...
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Posted by admin on Mar 31, 2024 in |
Introduction: The analgesia effect of anesthetic drugs namely Ropivacaine, can further be enhanced with adjuvants. For postoperative pain management in infra-umbilical surgeries, Ropivacaine with an adjuvant can be used through a Transversus Abdominis Plane (TAP) block, which is a simple and clinical anatomical landmark procedure, suitable in remote areas without advanced modern technical tools. Aims: Fentanyl and Dexmedetomidine (Dexmed) were used as adjuvant to Ropivacaine, injected in TAP, postoperatively, and were compared in terms of pain relief. Material & Methods: In this randomized comparative study, undertaken from January 2021 to August 2022, 60 patients were randomly divided into two groups of 30 each, Group A- Injection Fentanyl (25 mcg) + Ropivacaine (0.375%) in 20ml dilution and Group B- Injection Dexmed (25 mcg) + Ropivacaine (0.375%) in 20 ml dilution were injected in TAP block on either side. The outcome was studied at 3, 6, 9, 12, and 24 hours, postoperatively. Results: The mean duration of analgesia in patient’s of group B was higher and statistically significant (“p-value”<0.001) than group-A....
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Posted by admin on Mar 31, 2024 in |
Okra (Abelmoschus esculentus (L.) Moench.) is an important nutrient-rich vegetable crop also known as “lady’s finger”, widely grown in the tropics and sub-tropics mainly for its edible pods and is an alloploid. The haploid technique has been used in plant breeding for the improvements of plants and to develop new varieties in a relatively short time. Hence, we have optimized several factors such as plant growth regulators (PGR), sucrose concentration, type of media and culture conditions for callus induction from the anther and ovary of okra (Parbhani Kranti Hybrid). In this research, the effects of the microspore developmental stage, time of bud collection, different combinations of hormones, and culture condition on anther culture were studied. The explants were cultured on various combinations of PGRs i.e., (IAA, 2,4-D, KIN, BAP, IBA and TDZ) and various concentrations. The optimum developmental stage of microspore for callus initiation was achieved from flower buds of okra and its size was about 12 mm long, and showed significantly higher percentage of callus induction. The optimum stage for...
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Posted by admin on Mar 31, 2024 in |
This study focused on the development and evaluation of solid dispersions of Tinidazole, aimed at creating a fast-release tablet formulation. The preparation involved using carriers such as PEG 4000 and HPMC. Solid dispersions were created using both solvent evaporation and fusion methods. The resulting solid dispersions exhibited desirable properties, appearing as fine and free-flowing powders. Interaction studies, including IR spectra analysis, revealed no significant interaction between the drug and the carriers employed. Furthermore, uniform drug content was observed across all prepared solid dispersions. Correlation studies between the percentage of carriers in the dispersions and the dissolution behavior of pure Tinidazole indicated a positive relationship. Dissolution kinetics analysis demonstrated that the release of Tinidazole from all dispersions adhered to first-order kinetics. Notably, PEG 4000 emerged as the most effective carrier, yielding the fastest dissolution rate. The sequence of dissolution rates from various solid dispersions was determined. To extend the evaluation, Tinidazole solid dispersions in a 1:2 drug-to-carrier ratio with PEG 4000 were formulated into capsules. These capsules exhibited significantly enhanced...
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