Posted by admin on Sep 30, 2018 in |
Peptic ulcer is a condition associated with a number of factors involving excessive acid secretion in the stomach. This condition is difficult to control with single drug therapy and complete cure cannot be achieved. Even after discontinuation of the drug the relapse rate is high, and the long-term use of synthetic drugs produces adverse effects on the human body. The present study is expected to diminish millions of people suffering from ulcer in the country. This will not only provide them relief but will be safe enough from side effect as observed in allopathic medicines. So present study was to investigate gastro protective effect of selected Indian medicinal plant Trichosanthes dioica belonging to family: Cucurbitaceae. 50% ethanolic extract of Trichosanthes dioica fruit extract (TDE) was used for gastro protective effects on experimental models in rats. The entire drug solutions were prepared in 1% CMC solution and administered twice daily for five days or 10 days for prevention using three distinct animal models Model 1: Pylorus ligation + aspirin induced...
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Posted by admin on Sep 30, 2018 in |
The aim of the study is to investigate the capacity of pyrimidine derivatives like the active ingredient of Xymedon (I) and its derivative, salt-like conjugate with L–ascorbic acid (II) to stimulate liver recovery when damaged by toxic hepatitis. The study was done on out breed white rats. The liver damage was induced by carbon tetrachloride (injected 50% oil solution subcutaneously, once per day, 2-4 times, dose of solution 2 ml/kg). Tested compounds ((I), (II), Thiotriasolinum) were administered orally in the dose 20 mg/kg within 5 days. The new derivative (II) possesses pronounced hepatoprotective properties. It was established the obvious advantages of (II) in comparison with both Xymedon and Thiotriasolinum. Application of (II) improves of general medical condition of the animals (increase in the survival rate up to 100 %), the structure and morphology of their liver (reducing the symptoms of destructive, degenerative and irreversible changes to hepatocytes) and biochemical markers of cytolysis, synthetic and metabolic liver ability in blood (recovery in the levels of alanine-aminotransferase, aspartate-aminotransferase, γ-glutamyl-transpeptidase, total protein,...
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Posted by admin on Sep 30, 2018 in |
Terminalia catappa Linn. belongs to the family Combretraceae found in tropical regions of Asia, Africa and Australia, which is commonly called as Indian almond, sea-almond, tropical almond, wild badam. The fruit is useful in bronchitis and bowels. Juice of leaves is used in the preparation of the ointment for scabies, leprosy, cutaneous diseases and also as analgesic. The root bark is used in dysentery and diarrhoea. The stem bark cures fevers. The oil yielded from kernels is used commercially as a substituted for almond oil. According to the literature the different parts of the plants is used in many therapies including, antibacterial anticlastogenic, antioxidant, antifungal, antiulcer and molluscidal activity, management of sickle cell aneamia, anticancer, anti HIV reverse transcriptase, hepato- protective, anti-inflammatory, antidiabetic. In this study the methanol extracts of two varieties of Terminalia catappa (yellow and red variety) leaf was screened for antifungal like Candida albicans and Aspergillus niger and antibacterial like Eschiershea coli, Staphylococcus aureus, Citrobacter species, Enterococcus faecalis, Pseudomonas aerogenosa and Bacillus cereus was evaluated. The...
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Posted by admin on Sep 30, 2018 in |
The work was under taken as an attempt to prepare quick release films of ebastine with the purpose of developing a dosage form for very quickly on set of action, which will be beneficial in managing severe condition of allergies, aiding in enhancement of bioavailability. It is necessary to prepare ebastine as fast dissolving oral films to bypass the first pass metabolism. Ebastine was prepared as solid dispersion. Ebastine solid dispersion was incorporated in a different concentration of polymers such as pullulan, HPMC and PVP for the development of fast dissolving films. Propylene glycol was used as a plasticizer and aspartame as a sweetener. Films were prepared by a solvent casting method. The developed films were subjected for the physicochemical characterization such as uniformity of thickness, uniformity of weight, tensile strength and % elongation, folding endurance, surface pH, drug content uniformity, disintegration time, in-vitro drug release and ex-vivo permeation study. The formulations showed disintegration time within 25 sec. FB5 was found to be the best formulation, and has shown...
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Posted by admin on Sep 30, 2018 in |
In the current study, synthesis of silver nanoparticles (AgNPs) using swertipunicoside was tested against human breast cancer cell line (MCF-7). The swertipunicoside was tested against the normal cell line such as vero cells to find out the toxicity of the compound. The synthesized AgNPs were characterized using UV-visible spectroscopy, x – ray powder diffraction (XRD), fourier-transform infrared spectroscopy (FTIR) and field-emission Scanning Electron Microscope (FESESM) with energy dispersive spectroscopy (EDAX). The synthesized silver nanoparticles was checked with the colour variation and it was confirmed by UV-vis spectral analysis. The morphology of the synthesized nanoparticles were analysed using FESEM along with EDAX. The XRD was done to find out the crystalline structure of the compound. FTIR measurements are carried out to identify the possible biomolecules responsible for capping and efficient stabilization of the silver NPs synthesized using swertipunicoside. The synthesized AgNPs and swertipunicoside was tested against the MCF-7 cell line to find out the cell viability. Our results showed that the compound and synthesized silver nanoparticles inhibited the proliferation of...
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