Posted by admin on Sep 30, 2018 in |
Background: Salavana upanaha churna is a herbal compound drug consisting of Godhuma churna (Triticum aestivum L.), Rasna churna (Pluchea lanceolata (DC.) Oliv. & Hiern), Devadaru churna (Cedrus deodara (Roxb.) G.Don), Erandamoola churna (Ricinus communis L.), Vidanga churna (Embelia ribes Burm.f.), Vacha churna (Acorus calamus L.) and Saindhava lavana (rock salt) as main ingredients. Salavana upanaha churna is used extensively in management of spastic cerebral palsy in children. Aim: To standardize Salavana upanaha churna. Materials and Methods: Physico‐chemical studies like organoleptic characters, Powder microscopy, Loss on drying and HPTLC were carried out as per the WHO guidelines, Ayurvedic Pharmacopoeia and Indian Pharmacopoeia. Conclusion: Standardization tests done on Salavana upanaha churna helped in authenticating and ensuring the quality of the...
Read More
Posted by admin on Sep 30, 2018 in |
Oxidative stress is involved in the pathogenesis of various degenerative diseases like cancer, inflammation etc. Thus, the study of antioxidant activity of natural molecules has remained a fertile ground for the researchers. In continuation of that effort, the present study was designed to evaluate the antioxidant, cytotoxic, antibacterial and anti-inflammatory potential of chloroform extract of Stereospermum chelonoides leaves (SCLC). Preliminary phytochemical analysis followed by total phenol and total flavonoid determination assays were carried out. Antioxidant potential was evaluated using DPPH radical scavenging assay, total antioxidant capacity, ferric reducing antioxidant power and cupric reducing antioxidant assays. Brine shrimp lethality bioassay and MTT based cytotoxicity assay was also conducted. Antibacterial assay was carried out using disc diffusion method on both gram-positive and gram-negative bacteria. Croton oil and xylene induced ear oedema models were used to determine anti-inflammatory activity. Phytochemical screening ensured the presence of various secondary metabolites notably polyphenols (38.04 ± 0.77 mg/g, GAE) and flavonoids (130 ± 7.86, mg/g, QE) which explained its dose dependent antioxidant activities. Moreover, cupric ion...
Read More
Posted by admin on Sep 30, 2018 in |
Naturally occurring non-starch polysaccharides are known for their therapeutic value. This paper describes isolation, characterization and evaluation of glucose lowering potential of one such plant polysaccharide isolated from the leaves of the plant Vitex negundo. It was isolated and characterized using various analytical techniques and biochemical tests which confirmed the presence of carbohydrates and elements such as C, H and O. It demonstrated a reduction in glucose concentration in-vitro, however non-significant in comparison to standards. In-vivo, it was given per orally in fasting male C57 mice at 10, 30 and 100 mg/kg single dose post 30 min of which serum glucose was recorded. Glucose load was given 30 min after administering crude polysaccharide after which serum glucose concentrations were estimated at 15, 30, 60 and 120 min. Obtained results suggest a non-significant reduction in AUC as well as individual glucose levels at all the time points in crude polysaccharide treated animals in comparison to vehicle control in fasting as well as glucose loaded conditions. Thus, the crude polysaccharide isolated...
Read More
Posted by admin on Sep 30, 2018 in |
The study carried out to find the effect of Aloe vera extract on the toxicity induced by INH – RIF in male Wistar albino rats. We have perform the experiments on rats for 30 days and found the effect on histological alternations of liver by two different method. Firstly, by Compound microscopy and the same tissues were further process through SEM microscopy. We have found the effect of Aloe vera extract and isoniazid and rifampicin on histological architecture of liver. We found that there is partial restoration of hepatic function as evident from normalization of serum markers of liver function, and we were able to show hepatoprotection against INH+RIF induced hepatotoxicity, as evidenced by the partial reversal of increased serum transaminases showed trend towards returning to normal (but partially) by supplementation of Aloe vera indicating partial hepatoprotective effect. Co-administration of Aloe vera extract along with anti-tuberculosis drugs showed hepatoprotection in some extent against INH-RIF...
Read More
Posted by admin on Sep 30, 2018 in |
Background: Cervical cancer is the second most common cancer in women worldwide, with over 90% of cases the occurring in developing countries. India attributes to about 15% of the cancer deaths in the world mostly in rural areas. This dangerous disease can be effectively prevented by creating awareness programs and the possibility of effective management with early screening. Methodology: A prospective questionnaire-based survey was conducted among women for a period of six months i.e., from 1st January 2016 – 30th June 2016. Results: Most of the study populations were students. Among them women were 353. Majority of the women 305(86%) have not attended screening stating few reasons. Among the 48 women who attended the screening, 23(47.9%) were identified with various symptoms and are on treatment. Out of these, 3 members were diagnosed with carcinoma of the cervix. Barriers such as a low economy, cultural inheritances, lack of awareness, lack of females in the testing centres etc., were identified. Conclusion: All the health care providers and primary health care centres...
Read More
