Posted by admin on Sep 30, 2018 in |
Jackfruit peel is one among the under-utilized waste materials. In the present study, cellulose was extracted from de-pectinated peel. The peel was treated with alkali followed by a chemical process treatment. The yield of jackfruit cellulose was 27g / 100g of dry matter. Water and oil holding capability was a good retention value and higher hydration capacities of cellulose. The bulk, true densities and carr’s index of cellulose were 0.17 ± 0.05 g/ml; 0.005 g/ml and 10.561%. Jackfruit cellulose foaming capacity was 2.99 % at pH 9 and foaming stability was maintained at pH 7, until the end of time (2h). Jackfruit peel as a potential source of natural cellulose has been comparing favourably with commercial grade cellulose used for food, pharmaceutical, and cosmetic...
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Posted by admin on Sep 30, 2018 in |
Polyalthia korinti (Dunal) Benth. & Hook. F. is a rare Indo – Sri Lankan species of Annonaceae family and are traditionally used by tribal people of Ghats region, India for treating several ailments. The number of mature plants and the area of its distribution are too low and this species is placed under the vulnerable critically endangered category. The present study deals with the pharmacognostic and physicochemical evaluations of the leafy part of this plant and was undertaken as an initial step to aid in documentation, quality assurance, proper identification etc. and appropriately to investigate the plant material for its ethanomedicinal claims. Macro and micro morphological parameters of leaf and dried leaves powder were set down following standard procedures recommended by Ayurvedic Pharmacopoeia of India. Macroscopic study of leaf revealed some of the characteristic features like size, shape and color and in microscopic study internal characteristic features like epidermis, cortex, xylem, phloem, trichomes, and stomata were noted. Physicochemical parameters like total ash value, water soluble ash, acid insoluble ash,...
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Posted by admin on Sep 30, 2018 in |
ABSTRACT: Fibre rich pasta were prepared by substituting refined wheat flour with carrot pomace powder (CPP) at 5%, 15%, and 25% and evaluated for its physical properties, chemical composition, textural properties and sensory characteristics. The fat content of the pasta showed no pronounced variation. The hardness of the pasta increased with increase in the level of incorporation of CPP in the flour blends. CPP improved the appearance of pasta by imparting it attractive colour; however the texture score decreased with the increase in the level of supplementation. Pasta with 15% CPP was found to be most acceptable due to attractive appearance; and better taste and...
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Posted by admin on Sep 30, 2018 in |
The objective of the present study is to develop a pharmaceutically stable sustained release matrix tablets of Baclofen and perform the pre-compression, post compression and in-vitro evaluation studies of developed formulation. In this study sustained release matrix tablets of Baclofen were prepared by wet granulation method using mannitol, HPMC K4M, sodium alginate, HPMC K15 in various concentrations. All the formulations have showed acceptable Pharmacopeial standards. Formulation F9 have extended the release of Baclofen upto 12 h. Model fitting analysis for formulation F9 fitted in the zero order model and korsemeyer- peppas model. The “n” values obtained from the peppas-korsemeyer equation suggested that, drug release was non-fickian diffusion mechanism. Successful formulation was found stable after evaluation for physicochemical parameters when kept for 30 days at room temperature, 40 ºC and 2-8...
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Posted by admin on Sep 30, 2018 in |
The objective of the present work is to develop orodispersible tablets of Metformin hydrochloride using agar as natural super disintegrant to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Fast dissolving drug delivery system has numerous advantages over conventional dosage form like tablet, capsule, syrups etc. Formulation of nine batches out of which batch F5 with 6% super disintegrant was found to have better results in compare to other formulations, the F5 batch was passed with friability test and found negligible loss (0.4%), Then the batch was further evaluated for disintegration test and found to have 11.03 sec and in-vitro dispersion was found to be 15 sec in simulated saliva fluid and percentage drug release was evaluated to be 98.5% in less than 30 min. Hence, F5 batch was found to be better as it contain 6% treated agar. It shows further potential to carry animal...
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