Posted by admin on Sep 30, 2018 in |
Antibiotic resistance continues to pose a significant problem in the management of bacterial infections despite advances in antimicrobial chemotherapy and supportive care. Therefore, it is necessary to search the other alternatives that can be effective in the treatment of these infections. The present work was aimed to evaluate the antibacterial and antibiotic-potentiation activities of lemon against drug resistant phenotypes. The sensitivity of S. aureus and P. aeruginosa was determined by performing antibiotic sensitivity test (AST). They were found to be resistant to tested antibiotics and since S. aureus was resistant to oxacillin it was classified as methicillin resistant S. aureus (MRSA). The phytochemical analysis of lemon juice and lemon peel extract showed presence of flavonoids, phenols, steroids, reducing sugar and alkaloid. Antioxidant activity which was determined by Ferric Reducing Antioxidant Power (FRAP) assay method showed increasing trend in reducing power with the increase in concentration for both samples. The antibacterial activity of lemon juice, lemon peel extract and citric acid was screened against resistant isolates by using agar well...
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Posted by admin on Aug 31, 2018 in |
Intravenous administration of 5-Fluorouracil (5FU) produces severe systemic, dose-related side effects due to its cytotoxic nature, additionally, 5FU is rapidly absorbed from the stomach after oral administration. Therefore a combined floating-bioadhesive tablet (FBT) of 5FU has been developed in order to reduce the dose and associated side effects in other sites of the body. The tablets were prepared by direct compression technique. Hydroxy propyl methyl cellulose (HPMC) K15M was used as a release retardant polymer while carbopol-971P, guar gum and sodium alginate were used as bioadhesive polymer. The pre-compression characteristics shown fair flow behaviour and core tablet properties were within the Pharmacopoeia limit. All formulation batches reported satisfactory floating lag time in a range of 125 – 500 sec and remained buoyant for more than 6 h. Kinetics of dissolution data demonstrated that formulation batch FB4, FB9 and FB10 follow Korsmeyer-Peppas model, FB11 follows first-order kinetics; and FB1, FB2, FB3, FB5, FB6, FB7, FB8, FB12 and FB13 follows Higuchi Matrix model. Analysis of the data revealed that formulation batch...
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Posted by admin on Aug 31, 2018 in |
Free radicals are molecules with an unpaired electron that very unstable and react quickly with other compound to gain stability. Once the process is started, it can be a cascade reaction resulting disruption of a living cell. The free radicals formed in our body are combated by antioxidants then interact with free radicals and terminate the chain reaction before vital molecules are damaged. Moringa oleifera leaf extract well known can be as a source of antioxidant since it contains flavanoids for reducing free radical. This study was design to produce a crude extract of dark green and bright green of M. oleifera leaves using different solvent to determine its antiaging effect in male mice Mus musculus Swiss Webster. The antioxidant capacity of the extract were carried out using TMAMQ (Tetramethoxy Azobizmethylene Quinon) and ABTS (2, 2-Azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) method, while the antiaging activity were assessed by histological approach. The results showed that the highest antioxidant capacity was achieved by dark green M. oleifera leaves ethanolic extract followed by double-destilated...
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Posted by admin on Aug 31, 2018 in |
Natural drugs are boom to mankind. They have few side effects as compared to allopathic medicines. Psidium guajava, is an important food crop and medicinal plant in tropical and subtropical countries is widely used like food and in folk medicine around of the world. Psidium guajava linked with the antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, cardio active, anti-cough, antidiabetic, anti-inflammatory and anti-nociceptive activities and also used as hypoglycemic agent. Decoction of the bark used for diarrhoea and fever of Manilkara zapota. It contains linoleic acid, oleic acid, unsaturated fatty acids, linoleic acid, tannins, flavonoids. Crude extract of Manilkara zapota and Psidium guajava showed anti-microbial activity against gram positive Bacillus subtilis, Staphylococcus aureus and gram negative Escherichia coli, Salmonella typhii. The alcoholic fractions of leaves of Psidium guajava and Manilkara zapota were taken. The concentrations of leaf extract are made and evaluated for antimicrobial activity. DMSO is used as standard for antimicrobial assay. Highest zone of inhibition seen on the concentration of (0:2) and (0.4:1.6 ) for all...
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Posted by admin on Aug 31, 2018 in |
Paneer has great value in diet because it is a rich source of high quality proteins, fat, and minerals. Paneer has a short life span of 2-3 days of refrigeration storage, but freshness of the product is lost after one day. So, the present study was carried out to know the quality of different brands of paneer sold in Delhi City. A total of 80 packets of eight different brands were analyzed for their quality. Wide variation in chemical composition like moisture (49% to 64%), fat (13.5% to 24%), protein (18% to 23%) and lactose (1.75% to 4.23%) existed in the samples. Total bacterial count was observed between 25.40 and 41.10 × 104/gm, yeast and mold count was observed to be 13.75 and 20.90 × 101/gm, coli-form count was 3.95 to 7.65 × 101/gm and Staphylococcus aureus count was 1.10 to 2.20 × 101/gm. Instrumental hardness value varied between 27.56 and 62.22 N. About 75% of the brands did not conform to Food Safety and Standards Authority of India...
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