Posted by admin on Aug 1, 2018 in |
Sickle cell anemia is a hemoglobin disorder, which is an autosomal recessive type affects millions of children of underprivileged and tribal area every year. Because of its devastating complications sickle cell is considered a major health problem in India and the entire world. Since many years, majority of the tribal population in the South Gujarat region are suffering from this lifelong disorder, which is incurable till date. The study to clinically evaluate T-AYU-HMTM, a novel herbo-mineral preparation has been performed in patients with sickle cell anemia. The prior ethics approval for the study was obtained. This study was a non-randomized and efficacy comparative type study in which folic acid used as standard. The results were analyzed by using mean ± SEM and one-way analysis of variance. Results from the study show the drug is effective in alleviating the clinical symptoms of patients. Results showed drug is able to sustain the level of red blood corpuscle. The drug also sustained hemoglobin level by reducing sickle hemoglobin balancing it with raising...
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Posted by admin on Jul 31, 2018 in |
Nanobiotechnology in contemporary society is novel and has enhanced utility for size, distribution and morphology determination of various biomolecules. To prepare nano particles the used metals are gold, silver, mercury and platinum for significant applications in electronics, magnetics, optoelectronics and information storage. For our study we selected the sliver, since it is widely been used from ancient time for the treatment of bacteria, microbes, infections and serious burns as medicine or cosmetics and lotions in an emergence of new therapeutic agents. Plants are considered as environment friendly and efficient to produce in large-scale synthesis. So we selected the Trichodesma indicum for our study with combination of silver nitrate for silver ingredient in synthesis of silver nanoparticles (AgNPs) and their anti venom activity was studied. The properties of AgNPs of T. indicum were submitted to another journal had spherical particles of sizes 21 – 25 nm with active functional moieties of amino, carboxy, alcoholic and aromatics which contained the zeta potential of 30.9V. These properties of stem extract particles found...
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Posted by admin on Jul 31, 2018 in |
A series of, 2-thioxo-4-thiazolidinone (rhodanine) and 2,4-thiazolidine-dinone derivatives were synthesized by reacting 4-thiazolidine-dione/rhodanine moieties with 2-(4-formylphenoxy)-N-substituted-phenyl-acetamide, in equimolar proportions. The authentication of synthesized compounds was done by FTIR, 1HNMR, and mass spectrophotometry. The derivatives, N-(phenyl) -2- {4-[ (4-oxo-2-thioxo-1, 3-thiazolidin-5-ylidene) methyl]phenoxy}acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)-methyl]phenoxy}-N-(phenyl)-acetamide, were further screened for their anticancer properties against CEM cell lines. Cell viability was determined by trypan blue dye exclusion assay and cytotoxic effect of the compounds by MTT assay. The two derivatives, N-(phenyl)-2-{4-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy} acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)-methyl]phenoxy}-N-(phenyl)-acetamide were found to be anti-proliferative in nature at 75 – 100 μM and 100 – 250 μM concentrations, respectively. Thus, it can be established that the rhodanine derivatives, N-(phenyl) -2- {4- [(4-oxo- 2- thioxo-1, 3-thiazolidin-5-ylidene) methyl]- phenoxy}acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene) methyl] phenoxy}-N-(phenyl)-acetamide have anti-proliferative property against leukemic cell lines (lymphoblastic leukemia) and can be further optimized to improve its efficacy and...
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Posted by admin on Jul 31, 2018 in |
Traditional medicine and herbal formulations have been used by mankind for the cure and treatment of various diseases and disorders. Since time immemorable natural sources have been used as medicines by the humans. As per Indian System of medicine, Ayurveda, Siddha, Unani plants are formulated in various types of dosage forms like churna, gutika, asavas, aristasavlehas, etc. Various formulations with either Ayurvedic reference or as a household remedy or as a folklore medicine are commonly used. Balguti, Sitopaladi churn, Sootshekharmatra are few such traditional formulations which have been used commonly in various households. These formulations have immunomodulatory, expectorant and antacid properties respectively. Here in our studies we have reformulated these traditional formulations into new unit dosage forms. Considering the significance of patient compliance and market competition with modern dosage forms, present study involved phytochemical analysis of extracts used and their formulation of lozenges, jellies and dispersible tablets containing herbal ingredients. It was observed that, formulations were passing quality control tests. These formulations, being herbal would be with less side...
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Posted by admin on Jul 31, 2018 in |
The genus Litsea, is used in traditional and indigenous Indian and Chinese medicines for the treatment of diarrhoea, stomach ache, dyspepsia, gastroenteritis, diabetes, edema, arthritis etc. The objective of the present study was to evaluate the antidepressant activity of leaf and stem bark aqueous and ethanol extracts of L. floribunda (LF) as well as its interaction with conventional antidepressant drugs using Forced Swimming Test (FST) and Tail Suspension Test (TST) in mice. Albino mice were treated with extracts of L. floribunda (100 and 200 mg/kg, p.o.) and standard drug Imipramine (20 mg/kg, i.p.) for 14 days and after last dose administration on 14th day, all behavioural studies were performed and evaluated. The standard drug treated animals (20 mg/kg i.p.) evidently showed much less immobility time. Thus in FST model the antidepressant effect produced by group IV, group V, group VI, VII, VIII and X (100 and 200 mg/kg. p.o.) was comparable to that of group II i.e. standard drug Imipramine group where as in TST model, the antidepressant effect...
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