Posted by admin on May 31, 2018 in |
The present study was aimed to evaluate the effectiveness of some sesame oils obtained from different cities of Yemen. Sensitivity testing against some pathogenic bacteria and fungi were studied with four types of sesame oils in the laboratory pouring aqueous extract of the sesame seeds into the wells of the culture media. Escherichia coli, Staphylococcus aureus, Salmonella typhi, Candida albicans, Aspergillus niger and Aspregillus flavus were the microorganisms used and they were identified, confirmed and obtained from the Microbiology laboratory of the Sana’a University, Yemen. The results indicated that Semsum sanani and Semsum dwaini showed more antifungal activity against Aspergillus niger and Aspergillus flavus, while Semsum shahri, Semsum hadedi, did not show any activity against pathogenic bacteria and fungi. This study suggests that the compounds found in the semsum oil can form the basis for the development of novel broad spectrum antimicrobial formulations. These results support the notion that semsum oil may have many pharmaceutical...
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Posted by admin on May 31, 2018 in |
The present study aimed to investigate the effect of two levels from (green coffee, ginseng and their combination) on nutritional and biochemical status of obese rats. Forty eight male albino rats (Sprague Dawley Strain) used in this study, the rats divided into two main groups. The first main group (6 rats) fed on basal diet (as a control negative group). The second main group (42 rats) was fed eight weeks on high fat diet HFD to induce obesity in rats. The rats in the second main group divided into seven subgroups. Subgroup (1) fed on HFD, as a control positive group. Subgroups (2 and 3) fed on HFD containing (3% and 6% ginseng), respectively. Subgroup (4 and 5) were fed on HFD containing (3% and 6% green coffee), respectively. Subgroup (6 and 7) were fed on HFD containing (3% and 6% combination of ginseng and green coffee), respectively. The experimental period lasted six weeks. Results showed that, obese rats (control positive group) recorded significant increase p˂0.5 in (body weight...
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Posted by admin on May 31, 2018 in |
Introduction: Inflammation indicates with increased levels of inflammatory markers such as CRP is common in hemodialysis patients. Higher levels of CRP is strong predictor of morbidity and mortality in dialysis patients. The aim of this study was to evaluate the effect of pentoxifylline on serum CRP levels in hemodialysis patients compared with placebo. Methods: In this randomized clinical trial, 54 patients undergoing hemodialysis were evaluated at Zahedan’s hospitals in 1393 year. Patients were randomly divided into two groups receiving pentoxifylline and placebo. CRP Levels in Patients at months zero, two and four were tested. At the end, the data were analyzed with the software SPSS Ver. 20 and Wilcoxon and chi-square test. Results: The mean age of patients was 45.9 ± 14.8 years, 25 (46.3%) of the patients were male and 29 (53.7%) were female. CRP levels Before the intervention in patients receiving pentoxifylline was 4.5 ± 4.0, two months after the intervention was 2.8 ± 1.6 and four months after the was 2.3 ± 1.3. (P=0.001) CRP levels...
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Posted by admin on May 31, 2018 in |
Hyperlipidaemia is mentioned as one of the life-style-related diseases as much as so for diabetes. In the present study an attempt was made to develop herbal capsules, which are containing the extract of Murraya koenigii and Achyranthus aspera. One of the major concerns in designing new formulation is that the active ingredient should be compatible with all the excipients and packaging material components. Incompatibilities will affect the efficiency of the drug. Thermoanalytical techniques were effectively employed for the preformulations studies. The results obtained by the thermoanalytical techniques showed no chemical incompatibility between hard gelatin capsule shell and extract. The results were further confirmed by IR spectroscopy. The herbal capsule was stored at different temperatures viz., 25 °C, 40 °C and 50 °C for shelf life evaluation. The organoleptic properties of the herbal capsule remains unchanged at tested temperatures throughout the stability study. The shelf life of the herbal capsule was found to be 6.4 years. The Harborne’s Quantitative Alkaloid determination method proved to be selective, precise, linear, sensitive, and...
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Posted by admin on May 31, 2018 in |
Natural biodegradable chitosan-sodium alginate polymer combination is a promising candidate for preparing drug-loaded implants because of the availability and inexpensiveness of the polymers over the semi synthetic biodegradable ones. The main objective of this research was to prepare and evaluate a biodegradable implantable system of the drug metoprolol tartrate because it plays an important role in the treatment of high blood pressure, strokes, heart attacks and angina. 70:30 and 80:20 chitosan – sodium alginate combination implants of metoprolol tartrate with 15 and 30 minutes exposure time to glutaraldehyde for hardening were prepared. It was observed that loading efficiency and drug release could be influenced by varying polymer ratios, exposure times to glutaraldehyde and excipients. The implant formulated with 25 mg drug load in 70:30 chitosan – sodium alginate ratio with 15 minutes exposure produced the maximum sustained release for 15 days. Therefore, this formulation was chosen for preparing implants containing different excipients and the implants were evaluated for loading efficiency and in-vitro drug release. Morphological characteristics of the implants...
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