Posted by admin on Jul 31, 2024 in |
Background: Diabetes mellitus (T2DM) is a disorder in which the amount of sugar in the blood is elevated. Doctors often use the full name that is Diabetes Mellitus rather than Diabetes alone to differentiate from Diabetes Insipidus. Diabetes Insipidus is a relatively rare disorder that does not affect the blood glucose levels but just like Diabetes Mellitus, causing increased urination. Method: A prospective observational study was carried out among T2DM patients. Patient demographics, medication details, and blood glucose levels were recorded, examined, and the prescription pattern of the doctors was analyzed. Result and Discussion: The study included 209 T2DM patients. Metformin was more frequently prescribed single drug in 7.60% of participants. Dual drug combinations were Metformin and Glimepiride (49.04%), Metformin and Dapagliflozin (4.56%), Metformin and Vildagliptin (6.84%). About 61.84% were prescribed with short-acting insulin, 26.31% with intermediate-acting insulin, 10.52% with long-acting insulin, and only 1.31% of participants were prescribed with rapid-acting insulin. Dual drug fixed dose combination, Metformin is commonly combined with Glimepiride. A unique combination encountered was Remogliflozin...
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Posted by admin on Jul 31, 2024 in |
This study investigates the extraction of bioactive compounds from Beet vulgaris L. greens, a member of the Chenopodiaceae family known for its high antioxidant capacity. Despite being a horticultural product with substantial underused biomass, beet greens are traditionally discarded as waste, representing a lost opportunity for valuable bioactive components. This research focuses on the extraction of such bioactive compounds using different solvents (ethanol, methanol, and water) by Ultrasound Assisted Extraction (UAE). The results reveal that dil. methanol (1:1 v/v) extract named as hydromethanol extract, is particularly effective in extracting betalains, demonstrating higher betaxanthin content compared to ethanol and aqueous extracts. Aqueous extract excels in extracting total phenolics, while hydromethanol extract outperforms in extracting flavonoids. Ethanol extract exhibits superior efficiency in extracting alkaloids, while hydromethanol extract stands out for saponin and tannin extraction. This study underscores the significance of solvent selection in optimizing the extraction of specific bioactive compounds from beet greens. The findings contribute valuable insights into developing sustainable and efficient extraction processes for utilizing beet greens as a...
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Posted by admin on Jul 31, 2024 in |
Objectives: This observational cross-sectional study is aimed to assess the medication adherence and treatment satisfaction in hypertensive patients. This study was conducted at a public tertiary care hospital. Methods: Hypertensive patients of both the sex groups aged >60 years visiting outpatient department were enrolled. The Morisky Medication Adherence Scale and the Medication Interview Satisfaction Scale (MISS-21) were used to assess treatment adherence and satisfaction in the study population. The study included 153 hypertensive patients. Key findings: Most of the study participants had poor socioeconomic level and were in the age group of 60-65 years. The study participants reported high levels of treatment satisfaction. Patients reported good satisfaction across all four MISS domains: distress alleviation, communication comfort, compliance intent, and rapport. The frequency of nonadherence in this study was 24.2%. Conclusion: Despite reporting high levels of satisfaction, most patients did not adhere to their prescriptions. Aged hypertensive patients require special attention in hospitals to ensure proper treatment adherence. Patients with hypertension should be advised to take their medications for the...
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Posted by admin on Jul 31, 2024 in |
Plectranthus amboinicus, locally called Karpooravalli in Tamil Nadu, India, is known for its various traditional therapeutic properties. Rheumatoid arthritis is a chronic autoimmune disease where uncontrolled inflammatory markers are released to induce bone damage and pain. In this study, the methanolic extract of P. amboinicus was characterized phytochemically and subjected to in-silico analysis to evaluate its anti-inflammatory properties. The methanolic extract of P. amboinicus was subjected to gas chromatography-mass spectrometry (GCMS) analysis. The detected compounds were subjected to in-silico analysis with biomarkers specific for rheumatoid arthritis (RA) that is interleukin 6. Of the 86 profiled compounds, three belonging to flavonoid, porphyrin, and heterocyclic triazoles classification had the highest affinities for interleukin-6 and was compared with common DMARs given during RA treatment which had significantly low affinities to above 3 highest affinities bioactive compounds. The ADMET profile, drug-likeness, and bioactivity score were also calculated for all the GCMS profiled compounds, revealing adequate drug-like properties. In-silico analysis of the leaf extract of P. amboinicus compounds showed a promising result for its...
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Posted by admin on Jul 31, 2024 in |
Sweeteners are generally described in terms of their sweetness potencies relative to sucrose references. And, while caloric sweeteners have been found to have potencies invariant with sucrose reference concentration, noncaloric sweeteners decrease in potency as sucrose reference concentration increases. In this study, we develop methodology to determine the Concentration/Response functions for 9 (Omit “the”) noncaloric and 2 caloric sweeteners in water at room temperature. Two-Alternative Forced Choice methodology with a panel of 80 subjects was used to determine is sweet concentrations for these 11 sweeteners and multiple concentrations of sucrose. We found that the is sweetness data for all 8 of the high-potency noncaloric sweeteners are well modeled by the Law of Mass Action R = (Rm X C)/(Kd + C), where R is Response in % Sucrose Equivalents, Rm is Maximal Response in % Sucrose Equivalents, C is the sweetener Concentration in mg/L and Kd is the Concentration in mg/L resulting in Half-Maximal Response. We also found that the is sweetness data for the 2 caloric sweeteners Glucose...
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