Posted by admin on May 31, 2024 in |
The objective was to determine the effect of calcium phosphate composite with doxycycline molecularly included as a graft on bone defect after tooth extraction for slow delivery of drug. Methods: animal were distributed in to four groups: Group 1 (Blood Clot), Group 2 (TCP), Group 3 (TCP/PCL/PLGA), and Group 4 (TCP/PCL/ PLGA/ DOX/CD). An alveolar bone defect was created, and the analysis was conducted at preset intervals of T1 (14 days) and T2 (28 days). Results: The results of the histological study using H&E staining demonstrated the existence of newly created bone in all experimental groups. Group 4 exhibited the biggest area of newly formed bone at T1, and this observation was consistent across all time points examined. Group 4 exhibited a consistent volume across the measured time intervals, as evidenced by the existence of more advanced and structured trabeculated bone in T2 in comparison to T1. Even more Group 4, notably T2, displayed the highest proportion (47%) of newly formed bone area in comparison to Group 1 (36%),...
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Posted by admin on May 31, 2024 in |
The term nutrabeverage was applied to the product of alcoholic fermentation made by using Kefir grains. In the present studies initially, the pH of the pomegranate juice sample was 3.7, 3.5 for strawberry and 3.8 pH for pineapple. The titrable acidity optimum was found in pineapple at 3.37 % while 16% TSS was found in pomegranate. The highest TSS content before fermentation was observed at 160brix, 90brix and 14.30 brix in the pomegranate, strawberry and pineapple juice respectively. After 15 days of fermentation at 25°C with pH 4.5, the lowest TSS content of 120brix, 8.30brix, and 100brix in the pomegranate, strawberry and pineapple nutrabeverage was observed respectively. The titrable acidity was found to increase after 15 days of fermentation at 25°C in all nutrabeverage while reducing sugar was found to the maximum before fermentation. The lowest reducing sugar content was 9.73%, 6.81% and 8.82% in the pomegranate, strawberry and pineapple nutrabeverage respectively recorded after fermentation. The maximum alcohol content 6.9%, 4.3% and 5.2% in the pomegranate, strawberry and pineapple...
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Posted by admin on May 31, 2024 in |
The antidiabetic and antioxidant efficacy of traditional medicinal plants from North-Eastern India remains largely unexplored. This study seeks to address this gap by examining the properties of 11 such plants. The plant samples were subjected to extraction using four different solvents. Their antidiabetic potential was evaluated through in-vitro α-glucosidase and α-amylase inhibition bioassays, while the antioxidant activity was assessed using the DPPH Scavenging assay. The results were compared to the standard antidiabetic drug, acarbose. Out of the 11 plants, five species demonstrated significant antidiabetic properties, inhibiting more than 50% of α-glucosidase and α-amylase enzyme activities. The petroleum ether tuber extract of Stephania glandulifera exhibited the highest α-glucosidase inhibition (99%), followed by the methanol leaf extract of Begonia roxburghii (94%) and the water leaf extract of Antidesma acidum (85%). In the α-amylase inhibition assay, Equisetum debile methanol extracts showed a 64% inhibition, followed by the leaf extract of A. acidum with a 62% inhibition in the methanol leaf extracts. Comparatively, methanol and water leaf extracts of Debregeasia longifolia displayed 64%...
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Posted by admin on May 31, 2024 in |
Objective: This study aimed to carry out a phytochemical, pharmacognostic, qualitative, and quantitative evaluation of the medicinal plant Psidium guajava L., also known as guava, a member of the Mytaceae family. Methods: The present study provides pharmacognostic, phytochemical, and quantitative details of Psidium guajava L. Results: Plant-dried stem powder material was subjected to continuous hot extraction Soxhlet using solvents pet-ether, acetone, and ethanol. Phytochemical standardization was undertaken to detect the presence of bioactive agents along with TLC. Different physical parameters, like ash values, extractive value, loss on drying, etc., were evaluated for the powdered drug. The extracts were obtained from the Soxhlet method and subjected to preliminary phytochemical evaluation. Conclusions: The results of this study can serve as a valuable source of information for identifying this plant for future investigation and...
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Posted by admin on May 31, 2024 in |
The present study was conducted with an objective to evaluate the in-vitro antioxidant and hepatoprotective activity of three different medicinal plants. Due to the adverse effects of therapeutic agent with better hepatoprotective activity in modern medicine several plants have been screened for the aforesaid activity during last few decades detailed literature survey revealed that leaves of Aegles marmelos, Lawsonia innermis and Murraya koenigii plants were traditionally used for their liver protective activity. When healthcare providers refer to liver disease, they’re usually referring to chronic conditions that do progressive damage to your liver over time. Chronic liver diseases are not uncommon worldwide and are characterized by progressive evolution from steatosis to chronic hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. There is growing evidence that free radicals and reactive oxygen species play an important role in the progression of liver diseases and thus plants with free radical scavenging activity could play a crucial role in preventing the progression of liver disorders. The results of the present study demonstrate that, all 3 plants...
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