Posted by admin on May 31, 2018 in |
Hyperlipidemia is a major risk factor for CHD, atherosclerosis and diabetes. Present study has been conducted to evaluate the antioxidant and anti hyperlipidemic activity of Fragaria nubicola. All in-vitro antioxidant activities were concentration dependent, which were compared with standard antioxidants BHT and Vitamin C. At concentration of 700 µg/ml the DPPH radical scavenging activity of methanol extract was more than that of aqueous and ethyl actetate extracts. The highest phenolic content was observed in methanolic extract followed by aqueous and ethyl acetate. Superoxide and hydroxyl radical scavenging activity of extracts increased in dose dependent manner with highest in methanolic extract. To evaluate hyperlipidemic activity, 35 rats weighing 80-100gm were divided into 7 groups with five in each group and were fed with high fat diet for one month. Group I contained normal receiving water only, group II Hyper- lipidemic receiving high fat diet, group III Atorvastatin (10 mg/kg), group IV and group V receiving methanolic extract of 50 and 100 mg/kg, group VI and VII receiving aqueous extract of...
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Posted by admin on May 31, 2018 in |
The aim and objective of the present work is to design and develop immediate release tablets of pioglitazone hydrochloride to improve the patient compliance and desired bioavailability by selected delivery system by following immediate release mechanism. In the present investigation, super disintegrants used in the combination of 1:1 ratio were modified using co-processed technology with the solvents like acetone and methanol using solvent evaporation technique. The dissolution rate of the drug was significantly increased which reaches closer to the dissolution profile of marketed product. This was due to an increase in surface area of drug available for dissolution. The physical modification of super-disintegrants using co processing technique and selection of processed material with particle size specificity made the drugs to possess required characteristics as fast dispersible. The pre compression and post compression properties are determined as per the procedure prescribed. The drug release studies and kinetics indicate that the prepared tablets with co-processed superdisintegrants were best at its release in the entire tract of GIT due to their change...
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Posted by admin on May 31, 2018 in |
Background: Brachial plexus block provides minimal systemic impairment and excellent localized postoperative analgesia for upper extremity surgery. LA’s such as lignocaine, bupivacaine and ropivacaine are widely used along with adjuvant to improve the quality, onset and duration of block and to decrease postoperative analgesic requirement and systemic side effects. Adjuvant like α-2 agonist (Clonidine), opioids etc. are been added to LA’s. Clonidine is an imidazoline derivative with α-2 adrenergic agonistic activity. There has been seen a potentially clear synergism between clonidine and ropivacaine in various regional block anaesthesia. Material and Methods: In this randomized doubled blind controlled study, a total of 60 ASA grade I or II patients were taken and randomly allocated into 2 groups comprising 30 patients in each group. Group R includes patients which were given 30ml of 0.5% ropivacaine + 2ml normal saline and in Group RC 30 ml of 0.5% ropivacaine with 2 µg/kg clonidine in 2 ml NS. Sensory function was tested using pinprick and motor with concomitant inability to move the wrist...
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Posted by admin on May 18, 2018 in |
Introduction: Antibiotics are used to perish the growth of bacteria. Undesirable use of antibiotics is presently common all over the world. Parent’s knowledge and attitudes towards antibiotics play a vital role in the success of treatment process. Due to lack of knowledge, sometimes antibiotics are badly used for the treatment of infection. Study aims to evaluate the knowledge, attitude and practices regarding antibiotics use among parents for their children. Methodology: A cross-sectional study design was adapted, using convenient sampling technique in different areas of Lahore, Pakistan during the period June -2017 to November- 2017 by using a self-administrated questionnaire, involving 400 participants. Those mothers or fathers were included which had children under 5 years of age. Results: Results showed that 92(23%) of the respondents had poor knowledge, 252(63%) had moderate knowledge and 44(11%) had good knowledge. Significant associations were found between knowledge statements and age, number of children, education and spouse education. Significant associations were also found between attitude statements and age, gender, number of children, education and spouse...
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Posted by admin on May 18, 2018 in |
High fat diet and High fructose intake is the predominant lifestyle change that increased the epidemic of type-2 diabetes. HFD+HF feeding leads to oxidative stress mediated T2D through production of free radicals and decrement of antioxidant enzymes. Our present study focussed on the curbing effect of gymnemic acid on high fat diet and high fructose feeding induced oxidative stress mediated Type 2 diabetes mellitus. A total of 30 rats, 18 diabetic and 12 normal wistar rats were used for this study. Rats were HFD+HF fed and confirmed diabetic then animals were orally treated with gymemic acid (150 mg/kg body weight) daily for 30 days. Gymnemic acid supplementation effectively lowered the blood glucose and lipid levels expect HDL in HFD and HF fed diabetic rats. Free radical scavenging ability of gymnemic acid lead to the decrement of free radicals and thereby preventing macromolecular damage. Islets possess significantly lesser antioxidant potential when compared to other tissues and easily susceptible to oxidative stress under T2D condition. GPx a key antioxidant which can...
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