Posted by admin on May 31, 2024 in |
Amoxicillin Trihydrate is an extensively used antibiotic, and the accurate determination of its content in bulk and pharmaceutical dosage forms is of greatest importance. This thesis focuses on the development and validation of a High-Performance Thin-Layer Chromatography (HPTLC) method for the analysis of Amoxicillin Trihydrate. The study begins with an inclusive review of the existing analytical methods for Amoxicillin Trihydrate, highlighting the advantages and limitations of each technique. HPTLC is selected as the method of choice due to its simplicity, cost-effectiveness, and potential for routine analysis in pharmaceutical laboratories. The Chromatographic separation was carried out on Merck, Germany, TLC plates of silica gel 60 F254, 10 cm x10 cm using n-Hexane: ethyl acetate in the ratio of 7:3 (% v/v) as a mobile phase followed by densitometric measurements at 230 nm. The following method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification, and specificity according to the ICH (International Conference on Harmonization) guidelines. The calibration curve and results were found to be linear...
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Posted by admin on May 31, 2024 in |
Levodopa suffers from low oral bioavailability and less than 1% of the drug reaches the brain because of its peripheral degradation. This study aimed to prepare a nasal in-situ gel of levodopa and carbidopa to provide prolonged drug release, improve bioavailability, and increase drug uptake by the brain. Preliminary studies were carried out using different polymers. The concentration of polymer to be employed for the development of the formulations was deduced by carrying out placebo studies (F1-F12). All the batches were assessed for various parameters such as pH, viscosity, gelation time, and mucoadhesive strength. Out of 12 placebos, F11 which is pH and ion dual activated in-situ formulation showed satisfactory results. Therefore, F11 formulation was selected to prepare levodopa and carbidopa nasal in-situ gel. Drug incorporated formulation was found to have a viscosity of 2870.13 cps, assay of 95.7% of levodopa and 100.83% of carbidopa, and gelation time of 35 s, and the in-vitro drug release of levodopa and carbidopa after 8 h is 95.7% and 99.38%, respectively. Ex-vivo...
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Posted by admin on May 31, 2024 in |
Artificial sweeteners are non-nutritive sugar substitutes designed to provide sweetness without the calorie content of sugar. Examples like Saccharin, Aspartame, Neotame Acesulfame K and they are used in producing a low- or no-calorie diet to lose weight. In the last few years, they have be used in most of the products. Now a days artificial sweeteners are used because they have no calories and pose no risk of obesity. It provides the detailed description of some of the artificial sweeteners and their history, uses and adverse effects. They are often used in food and beverages as alternatives to sugar, providing individuals pursuing to reduce their sugar intake. The artificial sweeteners have an important impact on people who have diabetes or overweight. Validation was performed to know the Linearity, Precision, Ruggedness, Robustness, Limit of detection, Limit of quantification. A simple method is used to determine the artificial sweeteners like saccharin and Aspartame based on UV visible spectrophotometric method and this article provides the analysis of Saccharin and Aspartame and including...
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Posted by admin on May 31, 2024 in |
Introduction: The increasing trends for caesarean section (CS) not only in India but also globally have been a cause of concern. With the aim of comparing and analyzing CS rates worldwide, the WHO suggests Robson’s ten group classification system (RTGCS). Aims and Objectives: To find the groups of women with high CS rate which will help policymakers to target that specific groups of women for the reduction of overall CS. Materials and Methods: This was a retrospective study design using hospital records for women delivered between January 1, 2021 and December 31, 2021. Data were entered and analyzed using Excel and presented in percentages after using RTGCS. Results: Out of total 12645 women delivered during the study period, 7180(56.78%) were delivered by CS. The high CS rates were in group 9 (abnormal lie) – 100%, group 6 (breech nulliparous) -94.73%, group 5 (previous CS) -93.67%. In respect of all CS, the maximum contribution was done by group 5 (31.03%), group 1 (23.90%) and group 10 (20.55%). Conclusions: The result...
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Posted by admin on May 31, 2024 in |
Background: Chronic kidney disease (CKD) is defined as either kidney damage or a decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73m2 for 3 or more months. The prevalence of CKD in India is 17.2% and it is substantially higher in hypertension, Diabetes, and vascular disease patients. Polypharmacy potentiates the risk of medication-related problems, such as drug-drug interactions and complex drug. Objective: To assess the pattern of prescription and drug interactions in chronic kidney disease patients. Methodology: It was a cross-sectional study done from November 2022 to April 2023. The study was conducted on 60 in patients diagnosed with CKD in the Department of General Medicine in Victoria Hospital attached to BMCRI. The pattern of prescription was assessed in addition drug interactions were assessed by using Medscape – an online drug interactions checker. Results: The data demonstrated that most of the patients who were diagnosed with CKD were males (60%) and in the age group of less than 60 years (88%). 50% of patients belong to CKD stage...
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