Posted by admin on May 31, 2018 in |
Aspirin is a common medication used to treat pain, fever and inflammation. It shows the property of polymorphism and two polymorphic forms were characterized till now (Form I and Form II). Albendazole is another common medication used for the treatment of variety of parasitic worm infestations. This drug also shows polymorphism where two forms (Form I and Form II) of it were characterized till date. Various commercial aspirin and albendazole tablets were collected, powdered and after proper clean up procedure their melting points were determined to identify the polymorphic form of each drug sample. The detection of polymorphic form was further carried out by infra red spectral analysis. It was found that all the commercial aspirin samples under study belong to the polymorphic form II which is usually used in drug formulation. Polymorphic studies on commercial albendazole tablets showed that all the samples under investigation belong to the polymorphic form I which is commonly...
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Posted by admin on May 31, 2018 in |
Exacum lawii is folklore medicinal herb, boiled with oil and used traditionally for ocular infection. The aim of the present study is to evaluate the in-vitro antibacterial and antifungal activity against ocular infection. Ethanolic extract, petroleum ether extract and volatile oil were extracted from Exacum lawii whole plant. Antibacterial activity and antifungal activity against strains causing ocular infection were evaluated and Himalaya Optha-care Eye Drop was used as standard. The antimicrobial susceptibility was performed by agar disc diffusion assay method. The minimum bactericidal concentration (MBC) and minimum fungicidal concentration were determined for each extract and volatile oil by subculturing the samples. The volatile oil and the extracts of Exacum lawii showed bactericidal and fungicidal activities against some strains of bacteria and fungi causing ocular infection. Minimum bactericidal concentration for volatile oil was found in range of 3.125 mg/ml to 12.25 mg/ml, for ethanolic extract 6.25 mg/ml to 25 mg/ml and for petroleum ether extract 25 mg/ml to 50 mg/ml. Minimum fungicidal concentration of volatile oil was found to be...
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Posted by admin on May 31, 2018 in |
The aim of this experiment was to find out the in-vitro effects of the extracts of certain plants, considered to have medicinal value, on the erythrocyte model. The plants, selected for the study, were Tulsi (Ocimum tenuiflorum), Neem (Azadirachta indica) and Amla (Phyllanthus emblica).Three different concentrations of leaf extracts were prepared using tris-HCl, namely 0.3 mg/ml, 0.15 mg/ml and 0.075 mg/ml and their effects on the RBCs in blood samples were studied using optical microscope. Various morphological changes like haemagglutination, shrinking, swelling, distortions, granulation of the membrane and bursting of the cells were observed. The degree of occurrence of a certain morphological change on a particular blood type varied with a variation in its concentration. Also, the same concentration of the extract showed different morphological changes with different blood groups indicating that the blood type is also important in the effects shown by the cell membranes. The crude leaf extracts of medicinal plants significantly affected the integrity and thus, the morphology of the...
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Posted by admin on May 31, 2018 in |
The study was intended to evaluate the effectiveness of patient counselling in improving the quality of life (QOL) and knowledge, attitude and practices (KAP) of hypertensive and diabetic patients in a private educational institution. The study was conducted for a period of six months with the help of validated KAP and QOL questionnaire. Impact of patient counselling was studied by comparing the KAP and QOL score obtained after each subsequent patient counselling sessions. Data analysis was done by SPSS 16.1. Among 83 patients enrolled in the study, 40 were males and 43 were females. Out of 83 patients, 32 (38.55%) were diagnosed as hypertensives and 51 (61.44%) were diabetics. It was found that most of the hypertensives and diabetics were in the age group of 51-60 years. It was further found that the scores of knowledge (2.72 ± 1.80 to 4.88 ± 0.97), attitude (3.41 ± 1.73 to 4.94 ± 0.98) and practice (3.56 ± 1.86 to 6.28 ± 1.78) of hypertensive patients increased from baseline to second follow-up...
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Posted by admin on May 31, 2018 in |
The search for natural anti-microbials present in plants has been the target of intense scientific studies over the last years. The objective of this study was to assess the in-vitro antibacterial potential and in silico toxicology of the essential oil of Cinnamomum cassia (Chinese cinnamon) against E. coli and S. aureus strains. The essential oil was initially solubilized in tween 80 and dimethyl sulphoxide acid (DMSO). The antibacterial action was assessed by means of the minimum inhibitory concentration (MIC) determined from the microdilution in double-concentrated brain heart infusion broth (BHI) and the minimum bactericidal concentration (MBC) which was determined by the depletion in nutrient agar (NA) technique with aliquots of 10µL of the MIC, MIC × 2 and MIC × 4. The MIC and the MBC presented satisfactory and varied results; the E. coli LPM 4459, LPM 1243, LPM 4010 and LPM 4896 strains, had a MIC of 256 µg/mL and MBC of 512 µg/mL respectively. As for the E. coli LPM 2810 and S. aureus LPM 55 strains,...
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