Posted by admin on Apr 30, 2018 in |
The aim of this research was to develop controlled and sustained release formulation of hydrogel beads containing rabeprazole sodium, and to study the effects of Eudragit S100 coating on the release of rabeprazole sodium. The main objective was to develop a colon targeted drug delivery system to minimize – drug release in the upper gastro intestinal (GI) tract as well as to minimize GI adverse effects associated with NSAIDs. Alginate hydrogel beads of rabeprazole sodium were formulated by ionotropic gelation technique and the variables studied. The prepared Eudragit S100 coated hydrogel gel beads of rabeprazole sodium were characterized by determining particle size, % drug entrapment efficiency, swelling index and in-vitro release study. The mean particle size was found to be increase with the increment in concentration of sodium alginate and decrease in the concentration of calcium chloride. The % drug entrapment efficiency of the prepared hydrogel beads formulations was found in the range of 67.45 ± 0.23 to 82.89 ± 0.64. Swelling time analysis revealed higher swelling time at...
Read More
Posted by admin on Apr 30, 2018 in |
The present study was designed to investigate Analgesic activity of Chloroform extract and isolate 1 of Eulophia ochreata Lindl. and dicholoromethanolic extract and isolate 2 of Zingiber cassumunar Roxb. The analgesic activity was assessed by using acetic acid induced writhing method and hot plate method. In acetic acid induced writhing method the extracts and isolates of both plants was administered intraperitoneally at dose of 200 mg/kg to Swiss-albino mice. Chloroform extract (60.17%) Isolate 1(45.59%) and dichloromethanolic extract (55.48%) and isolate 2(48.07%) of Eulophia ochreata Lindl. and Zingiber cassumunar Roxb. respectively showed significant inhibition as in pain response as compared with standard aceclofenac (51.10%) at the dose of 10 mg/kg. In Hot plate method the extracts and isolates of both plants was administered orally at dose of 200 mg/kg to Swiss-albino mice. The chloroform extract and isolate 1 of Eulophia ochreata Lindl showed significant analgesic activity showing 55.84% and 66.25% when compared to the standard pentazocine(5mg/kg) as 50% at 60 min. Dichloromethanolic extract and isolate 2 of Zingiber cassumunar Roxb....
Read More
Posted by admin on Apr 30, 2018 in |
Conventional ophthalmic preparations exhibit poor bioavailability due to the rapid precorneal elimination of the drug, and the physiological constraints imposed by the protective mechanisms of the eye lead to the low absorption of the drugs resulting in a short duration of the therapeutic effect. In order to increase the residence time of the drug in-situ gelling systems were prepared and instilled as drops into the eye which undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of flurbiprofen ocular in-situ gel, based on the concept of pH – triggered in-situ gelation. Polyacrylic acid (carbopol) was used as the gelling agent in combination with hydroxy-propyl methyl cellulose (HPMC) which acted as a viscosity enhancing agent. The formulations were evaluated for clarity, pH measurement, gelling capacity, gelling temperature, drug content estimation, rheological study, in-vitro drug release study, sterility testing and stability studies. The physicochemical interactions between drug and polymers were investigated by fourier transform infrared (FTIR) spectroscopy. FTIR studies did not show any evidence of...
Read More
Posted by admin on Apr 30, 2018 in |
Bimetallic nanoparticles have several useful opto-electronic and catalytic properties that are different from those of monometallic nanoparticles. The development of non-toxic and eco-friendly protocols for the synthesis of bimetallic nanoparticles is a still less explored area. In the present study, bimetallic silver-gold nanoparticles were synthesized using Trichoderma reesei (NCIM 992). An effective approach for co-reduction of metal salts was adopted wherein the fungal biomass was grown under non-limiting conditions, followed by the addition of metal salts. The bio fabricated bimetallic nanoparticles were characterized using UV-Vis Spectroscopy, ICP-MS, SEM equipped with an EDS, FTIR and XRD. The fungal biomass color changed from colorless to dark purple within 2 days of incubation period. UV-Visible spectrum of the intracellularly produced bimetallic nanoparticles showed characteristic peak between 420 nm and 540 nm. ICP-MS of the residual salt concentration depicted the percentage of bioconversion of metal salts to metal nanoparticles. SEM-EDS studies confirmed the presence of intracellular silver-gold bimetallic nanoparticles. FT-IR analysis revealed the existence of peaks in the amide regions, a characteristic of...
Read More
Posted by admin on Apr 25, 2018 in |
Hydnora africana Thumb (Hydronaceae) is a parasitic flowering plant with significant global ethnomedicinal value. This study evaluated the toxicological effects of the acute and sub-acute dosing treatments of the aqueous root extract of Ha in male and female wistar rats using OECD guidelines 423 and 407. For the acute study, the extract was administered to the animals at single oral graded doses of 1000, 2000 and 5000 mg/kg body weight (b.w.) and subsequently observed for 14 days, while it was given at 250, 500, and 1000 mg/kg b.w. once daily for 28 days in the sub-acute testing. Clinical toxicity signs, behavioral changes, hematological and biochemical parameters were then monitored and evaluated. The result revealed that, at a limit dose of 5000 mg/kg b.w., the extract neither had treatment – mediated symptoms of toxicity nor mortality over the 14 days observation period. In the sub-acute study and particularly for the male rats, the extract significantly increased the serum levels of the erythrocytes and haemoglobin, while the platelet counts increased dose-dependently...
Read More
