Posted by admin on Jun 30, 2018 in |
Repaglinide is used in the treatment of type 2 Diabetes mellitus and has very short half life. The patient compliance can decrease when larger doses are administered two to three times a day. Sustained release formulation which maintains a plasma level of 8-10 h might be recommended for daily administration of repaglinide. The main objective of the present study was to develop sustained release formulation using hydrophilic release retardant natural and synthetic polymers i.e., Ocimum basilicum seed mucilage and HPMC K4M alone and in combinations respectively. Direct compression technique was used to prepare tablets which were evaluated for precompression and postcompression parameters. Nine formulations were prepared in which F1-F3 were prepared using Basil seed mucilage, F4-F6 by HPMC K4M and F7-F9 using both the polymers (Basil seed mucilage and HPMC) at 1:3, 1:6 and 1:9 to the drug and polymer ratios respectively. F8 was selected as the best formulation which sustained the drug release upto 98.61% in 10 h out of nine formulations (F1-F9). The selected formulation which was...
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Posted by admin on Jun 30, 2018 in |
A new, simple, sensitive, accurate and precise RP-HPLC method was developed for the estimation of quetiapine fumarate in human plasma. Full factorial design was used for the optimization of an extraction method. The main effect of volume of deproteinating agent, speed of centrifugation, time of centrifugation and temperature of centrifugation was found to be significant at P<0.0001 on all the responses. After deproteinization, the drug was analyzed on a C18 (150 × 4.6mm, 5 µm) column using UV detector. The mobile phase consisting acetonitrile and phosphate buffer (pH 3) in the ratio of 50:50 (v/v) at a flow rate of 1.0 ml/min. The standard calibration curve was constructed in the concentration range of 5 µg/ml to 30 µg/ml and linearity was found to be 0.999. Irbesartan was used as the internal standard. The retention time of quetiapine fumarate and the internal standard was found to be 5.42 and 2.89 min, respectively. No interference peak was perceived. The high performance liquid chromatography method was successfully demonstrated as rapid and sensitive...
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Posted by admin on Jun 30, 2018 in |
To develop new pulsatile release tablets of Rabeprazole sodium (RS), that can suppress drug release in stomach and release the drug rapidly after a predetermined lag time for about 4 h in intestine, a multiple unit dosage forms was designed that contain, drug-containing core, a coating to achieve time lag in drug release and an outermost acid resistant enteric coating. Time lagged press coating was performed using ethyl cellulose (EC) and different grades of hydroxypropyl methylcellulose (HPMC) in different ratios. The press-coated tablets were optimized by the drug release study and finally the formulation F17 containing 7:1 ratio of EC and HPMC K4M was selected as optimized formulation. This press coated tablet was further enteric coated with Cellulose acetate phthalate (CAP). The weight gain of the enteric coating was optimized based on the integrity of coating in an acidic solution for about 2 h. Formulation F21 was finally selected with 10% weight gain and rupture time of 120 minutes in 0.1N HCl. Further, the drug release from F21 formulation...
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Posted by admin on Jun 30, 2018 in |
This study evaluated the acetone extract of Crinum jagus bulbs for its antioxidant, and antiplasmodial properties. The bulbs of Crinum jagus are used in traditional medicine for various ailments. The antioxidant activity of the extract was evaluated using DPPH and nitric oxide free radical scavenging assay. The antiplasmodial activity (suppressive, prophylactic and curative activity) was evaluated in-vivo against Plasmodium berghei at 250 mg/kg and 500 mg/kg through the oral route in Swiss albino mice. Isolation and characterization of the active principles were done using GC-MS techniques. Phytochemical analysis of the extract revealed the presence of flavonoids, tannins, saponins, steroids and alkaloids. The LD50 was found to be greater than 5000 mg/kg. The extract showed a dose-dependent antioxidant activity against the various assays. The extract caused dose-dependent and statistically significant (P < 0.05) reduction of parasiteamia in the antiplasmodial suppressive and prophylactic study. Bowdensine and demethoxy bowdensine were the active principles found on chemical analysis of the extract, using GC-MS. The results indicate that this extract may possess antioxidant, prophylactic...
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Posted by admin on Jun 30, 2018 in |
Tridentate Schiff bases were obtained in succession from the condensation of ethyl 2-amino-5,6-dihydro-4H-cyclopenta [b] thiophene-3-carboxylate and different aryl aldehydes in 1:1 molar ratio. Zinc chloride complexes of these new aminothiophene Schiff bases were prepared in 1:1 metal: ligand stichometry. These complexes were characterized using IR, UV-Visible, elemental analysis and molar conductivity. Schiff bases displayed monobasic tridentate coordination with central Zn (II) ion and formed tetrahedral complexes. These complexes were evaluated for their antimicrobial activity against gram-negative, multidrug-resistant Metallo- β-lactamase (MBL) and Extended Spectrum β-lactamase (ESBL) producing uropathogens and for their antitubercular activity against Mycobacterium tuberculosis (H37Rv strain) to observe improved biological activity compared to parent Schiff...
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