Posted by admin on Jul 31, 2024 in |
In obese patients with noninsulin-dependent diabetes mellitus (NIDDM), reducing calorie intake improves glycemic control. The present study tested the theory that controlling calorie intake has an important role in long term, independent of weight loss in metabolic regulation of NIDDM patients. 23 women included in this study were selected, Antidiabetic therapy (except metformin) was discontinued concurrently with the start of VLCKD diet and Parameters were collected at starting program and once every 3 months for a year. In result, on T3 (after 9 months) ofVLCKD restriction produced substantial decreases in fasting plasma glucose for (19±9.31 ), HbA1c % (1±0.34),Weight loss (35.6±9.9), BMI (11.9±2.5 ), Tri Acyl Glycerol(22.99±19.27) and Total Cholesterol (52.5±4.89), and no significant decreasing in Creatinine is found .While on T4 ( after 12 months)there is a significant decreasing in: fasting plasma glucose for (18±8.41 ), HbA1c % (1±0.5), Weight loss (33.5±10.3), BMI (12.3±2.2 ), Tri Acyl Glycerol (18±22.1) and Total Cholesterol (46.7±21.5), and no significant decreasing in Creatinine. It is important to noticethe stability of biochemical parameters...
Read More
Posted by admin on Jul 31, 2024 in |
Diabetes is a chronic disease characterized by fasting blood glucose levels above 1.26 g/L. The aim of the present study was to evaluate the effect of the methanolic extract of Picralima nitida seeds on insulin and blood glucose levels in diabetic rats. Diabetes was induced in normoglycemic rats by injection of 1 mL alloxane at a dose of 125 mg/kg bw for three consecutive days. Blood samples were taken every other day to determine insulin and blood glucose levels. Diabetic rats were then treated for 14 days with 10, 20 and 50 mg/kg bw of P. nitida seed extract and 5 mg/kg bw of Glibenclamide®. At the end of treatment, the rats’ blood was collected again for determination of insulin and blood glucose P. nitida levels. The results obtained show that initial insulinemia, which was 16 ± 0.12 μU/mL, fell in diabetic rats (7 ± 0.004 μU/mL) before significantly increasing to 15 ± 0.3 μU/mL and 17 μU/mL ± 0.02 after treatment with P. nitida extract and Glibenclamide®. In...
Read More
Posted by admin on Jul 31, 2024 in |
Objectives: Grewia hirsuta Vahl. is a shrub explored for medicinal applications. It has anti ageing, boosting immunity, prevents loss and grey hair etc. Ethnopharmacological data suggests that the plant is extensively used as a nerve tonic and to enhance the cognitive properties. The basis of these medicinal uses seems to be antioxidant and anti cholinesterase activity. In order to establish the scientific basis between medicinal uses and its mechanism of action, antioxidant and anti cholinesterase activity investigations were carried out. Methods: Evaluation of free radical scavenging and anti cholinesterase activity was carried out using DPPH (1, 1- diphenyl-2-picryl hydrazyl), hydroxyl radical scavenging and ferric reducing method using ascorbic acid as a standard. Cholinesterase inhibitory potentials were measured by Ellman’s method against Rivastigmine. Results: The inhibitory concentration of hydro ethanolic extract of Grewia hirsuta (HEEGH) (IC50 27.25) in DPPH. In reducing power assay (IC50 65.32) and Hydrogen peroxide scavenging activity (IC50 98.28). The inhibitor concentration of acetylcholinesterase by standard (Rivastigmine) was (IC50 14.40μg/ml), and the extract was (IC50 133.4μg/ml), whereas,...
Read More
Posted by admin on Jul 31, 2024 in |
Objectives: Valvular Heart Disease (VHD) is an important cause of cardiovascular morbidity and mortality worldwide. The aim of this study was to establish the frequency of VHD on the basis of echocardiographic parameters, assess etiological factors, quantify the clinical spectrum and evaluate the medical management of VHD. Methods: This observational cross-sectional study was conducted for a period of 5 months from May to September 2021 at a tertiary care hospital in Tamil Nadu. A total of 101 patients, both in-patients and out-patients visiting the cardiology department were included for the study. Results: Among the 101 participants, the mean age was 55.43 ± 14.91 with 55.4% of them being males. The most common etiology was found to be degenerative (75.2%). The most commonly encountered valve lesions included mitral regurgitation (67.3%) followed by aortic regurgitation (36.6%), tricuspid regurgitation (33.7%) and mitral stenosis (21.8%). The prevalence of VHD and VHD of degenerative etiology increased with age >40. The occurrence of VHD symptoms was also higher with age >40 (P<0.001). Conclusion: The major...
Read More
Posted by admin on Jul 31, 2024 in |
Fresh Aloe vera plant leaves were brought from botanical garden and sample was identified and brought to the laboratory in the Department of Zoology, Patkar-Varde College, Goregaon (W), Mumbai. 50 grams of leaves were then grounded with 50ml of distilled water in sterilized pestle and mortar. The yield will be calculated based on weight of the extract compared to the weight of the pulp of the leaves. Forty-eight (48) Sprague- dawley rats (average weight 150 – 250 g) of either sex were used for the experiment. The ETH and PAS drug and Aloe vera juice were given to respective groups daily for 28 days. At the end of the study animals were anesthetized and were sacrificed by cervical decapitation. Blood was collected via cardiac puncture and studied for WBC: White blood cell count, LYM: Lymphocytes, MID: Indicates the combined value of the other types of white blood cells not classified as lymphocytes or granulocytes, NEUT: Neutrophils, RBC: Red blood cell count, HGB: Hemoglobin, HCT: Hematocrit and PLT: The platelet counts...
Read More
