Posted by admin on Mar 31, 2018 in |
Medicinal applications of metals and its compound were reported centuries ago but it gained huge appreciation after the discovery of anticancer activity of metal based drug cisplatin. After cisplatin discovery many medicinal synthetic chemist moved into the field of organometallics for combating diseases and investigating the excellent pharmaceutical potential of metal complexes, giving birth to modern medicinal organometallic chemistry. Derivatization of the already existing drugs is the emerging field of pharmaceutical and synthetic medicinal chemistry. Working on metal complexes of already approved drugs can substantially reduce the time and money spent in clinical development. Organotin(IV), Cu(II), Zn(II), Fe(III) and Sb(III) complexes of Ribavirin were synthesized keeping the same in mind. These complexes were characterized by elemental analysis, IR, 1H, and 13C NMR spectroscopic studies. The synthesized complexes and the parent drug were screened for in-vitro biological activities. Interestingly some of the synthesized metal complexes of ribavirin have shown impressive antibacterial and antifungal on the other hand ribavirin was found to be...
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Posted by admin on Mar 20, 2018 in |
The present study was designed to compare the chemical and phytochemical compositions of Momordica charantia, Azadira chtaindica, Trigonella foenum-graecum and Phyllanthus emblica and subsequently, antidiabetic activities of T. foenum-graecum and a combination of polyherbal extract of T. foenum-graecum and M. charantia were evaluated on alloxan induced diabetic mice. The proximate and phytochemical compositions of the plants were quantitatively determined using standard methods. In order to evaluate antidiabetic activity, normal and alloxan induced diabetic mice were orally administered 0.5 mL aqueous extract of T. foenum-graecumand combination of T. foenum-graecum – M. charantia once per day for 7 days. These two plants were selected for antidiabetic activity based on their high phytochemical contents. A near normal blood glucose value of 98.5 ± 0.2 mg / 100mL and 97.02 ± 0.55 mg / 100 mL was observed in the 7th and 5th day experimental animals after administration of T. foenum-graecum and T. foenum-graecum – M. charantia, respectively and remained at the same level even after further oral administration. Consequently, it is evident...
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Posted by admin on Mar 8, 2018 in |
Osteoporosis is defined as low bone density with micro architectural deterioration of bone tissue leading to enhanced bone fragility and increased fracture risk. Knowing the treatment pattern of osteoporosis is imperative in achieving better health outcomes. Thus the purpose of our study was to assess the treatment pattern of osteoporosis in 8 different medical colleges and hospitals in Bangladesh situated in 2 different districts, Dhaka and Comilla between the periods of September 2015 to April 2016. A pre-designed questionnaire was given to 107 doctors in the hospitals and data was collected on sociodemographic and professional characteristics of the participating physicians along with their learning opportunities and different parameters of treatment and diagnosis. Majority of doctors, 89.7% had internet access at work place for getting updated on osteoporosis, 84.1% attended specialized osteoporosis programs but only 63.6% had subscription in medical journal or website, Around 58.9% practitioners used guidelines for osteoporosis and a greater percentage of doctors, 15.1% preferred bisphosphonates for treatment of osteoporosis. Preferred diagnostic tool was dual-energy X-ray absorptiometry...
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Posted by admin on Feb 28, 2018 in |
This study was undertaken to elucidate the serum antioxidant (Vitamin C), macro – minerals (Ca, Na, and K) and trace elements (Zn, Fe) concentration of in patients with metabolic syndromes. Metabolic syndrome was examined by following the definition developed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). Serum Vitamin C was estimated by phenyl-hydrazine spectrophotometry method, while Macro-minerals and trace elements were determined under coordination of two methods these was flame atomic absorption spectrometry (FAAS) and graphite furnace. This study found that Vitamin C is lowering significantly (p < 0.05) in patients with metabolic syndrome while compared with control subjects. Analysis of serum trace elements (Zn, Fe) and macro minerals (Ca, Na, K) explored low serum concentrations in examined patients significantly either than control group (P < 0.05). Pearson’s correlation analysis revealed negative correlation between blood glucose and Fe, Triglyceride and Zn level were found statistically significant. On the basis of our present study it can be asserted that depletion of Vitamin C, Zn, Fe,...
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Posted by admin on Feb 28, 2018 in |
Centella asiatica (CA) is a reputed medicinal plant that has been shown to have pharmacological effect on skin wound healing. The aim of the study was done to assess the effects of aqueous extract of CA on human dermal fibroblasts in an in vitro model of wound healing. Dermal fibroblasts were cultured with or without supplementation of aqueous extract of CA. Viability and proliferation of the fibroblasts cells were determined by MTT assay and cell cycle were analyzed by flowcytometry. In-vitro re-epithelization was assessed by scratch assay and migration rate was evaluated quantitatively by image analyzer. Gene expression of type I collagen, type III collagen, fibronectin and SMAA2 were studied via real-time RT-PCR. Supplementation with the aqueous extract of CA inhibited the fibroblasts’ proliferation significantly (p<0.05) at high concentration. Moreover, it also inhibited fibroblasts’ migration across the denuded area significantly (p<0.05) at a concentration of 194.15 μg/mL (IC50) when it was compared to the control. The gene expression of type I collagen, type III collagen, fibronectin and SMAA2 decreased...
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