Posted by admin on Apr 30, 2018 in |
Antacids are the commonly prescribed drugs for treating gastroesophageal reflux disease (GERD). As these are manufactured and marketed by various multinational and local companies there is a need for evaluating the cost effectiveness and efficacy of these antacids as a matter of public concern. In the present study an attempt has been made to determine and compare the acid neutralization capacity of antacid preparations sold across various retail pharmacies in Vijayawada, Andhra Pradesh, India to find out unit cost and effectiveness of antacid with respect to its composition and manufacturer. Six different antacid suspensions manufactured by different companies were evaluated for the oraganoleptic properties, viscosity, pH and particle size and were compared with each other. Acid neutralizing capacity was determined by titrimetric method. Cost effectiveness was done by calculating the cost per ml of antacid and efficacy was evaluated based on acid neutralizing capacity of antacid preparation. Suspension Medicaine® having higher acid neutralization capacity (30.22 mEq) with unit cost Rs.0.52/ml was found to be the most effective brand as...
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Posted by admin on Apr 30, 2018 in |
The purpose of this study is to achieve colonic release of anti-inflammatory drug sulfasalazine used in the treatment of inflammatory bowel disease (IBD) to minimise side effects with a novel method of single capsule with bilayer coating. Sulfasalazine is an anti-inflammatory drug which acts topically on the inflamed colon to provide relief. In the present study a time and pH dependent colon targeted system was developed and evaluated. Liquisolid plug (LSP) of poorly water soluble drug sulfasalazine was prepared to enhance its dissolution rate and bioavailability. Sulfasalazine liquisolid plug was filled in acrylic polymer coated capsule. This capsule was subsequently coated with ethyl cellulose + HPMC (combination) and eudragit S 100. The eudragit S 100 prevented capsule disintegration in stomach and combination of ethyl cellulose and HPMC prevented capsule disintegration in small intestine. The design of formulation hence ensured colon targeted delivery of drug, preventing premature drug release in stomach or small intestine and enhanced dissolution rate potentiating probable enhancement in bioavailability. In vitro release studies were carried out...
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Posted by admin on Apr 30, 2018 in |
In this paper, we investigate several topological indices in honeycomb graphs: Randić connectivity index, sum-connectivity index, atom-bond connectivity index, geometric-arithmetic index, First and Second Zagreb indices and Zagreb polynomials. Formulas for computing the above topological descriptors in honeycomb graphs are...
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Posted by admin on Apr 30, 2018 in |
Culture dependent phenotypic characterization analyses were applied to study the protease producing bacteria from Indian Soda (Lonar crater). The uniqueness of the Lonar lake water is its salinity and alkalinity. A total of one hundred and fourteen bacterial cultures were isolated from the water and sediment samples collected from the hyper alkaline saline environment of Lonar lake. The thirty two bacterial strains were found protease producing bacterial culture, out of them strain EW2 was selected for 16S rDNA sequencing, production and partial characterizations of protease on the basis of their maximum proteolytic activity. The phylogenetic position indicated the strain was related to phylum Firmicutes. Optimum enzyme activity was found to be at 80 °C and pH 9.5. The protease was highly stable over broad temperature from 40 to 90 °C, pH 7.0 – 12.0, showing excellent thermostablity and alkaline tolerant nature. The enzyme activity has enhanced by all metal ion which was tested in this studies indicating it was a metalloenzyme but inhibited by organic solvent except acetone. This...
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Posted by admin on Apr 30, 2018 in |
Dengue fever is an important public health problem in tropical and sub-tropical Continent. Recently the number of severe forms of the disease, dengue hemorrhagic fever, and dengue shock syndrome are increased. Dengue virus, a arbo-virus responsible for dengue fever and spread through its vector, Aedes aegypti. Controlling the mosquito is the good strategy to prevent this disease. The traditional chemical pesticides used to control mosquito have many drawbacks, and natural products are more acceptable in this aspect. The bio-efficacy of ginger (Zingiber officinale) and turmeric (Curcuma longa) ethanolic leaf extract was assessed against the fourth instars larvae of Aedes aegypti, under the laboratory conditions. Both shows moderate activity against Aedes aegypti larvae. However, the combined treatment of both leaf extract (1:1) shows highest activity. Combination of 50 µgml-1 turmeric and 50 µgml-1 ginger killed all of the population within 24 h. This is an eco-friendly and low-cost approach, may use to control Aedes...
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