Posted by admin on Feb 28, 2018 in |
The objective of present study was formulation and evaluation of fast release tablets of Fexofenadine hydrochloride. Fexofenadine hydrochloride is an anti-histamine with selective H1-receptor antagonist activity. In this investigation fast release tablets of Fexofenadine hydrochloride were prepared using cross povidone as a superdisintegrants by melt technology method. The Fourier transform infrared spectroscopy revealed absence of any drug – excipient interactions. The tablets were evaluated for pre-compressed evaluation like bulk density, tapped density, Hauser’s ratio, Carr’s index and angle of repose and post-compressed evaluation like weight variation, thickness, hardness, friability, wetting time, disintegration time, content uniformity and in-vitro drug release profile. The wetting time for all batches was found in the range of 20.1 to 80.1 sec. All the tablets were disintegrated within 100 seconds. In-vitro percent drug release was found up to 98.25 % in 30 min. The formulation 4 showed better result in wetting time, disintegration time and drug release...
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Posted by admin on Feb 28, 2018 in |
Sorghum is an important food source with substantial nutritional value. An in vitro antioxidant evaluation of different extractions of graniferous sorghum [Sorghum bicolor (L.) Moench] hybrid Guanipa 71 was proposed here. Acetone / water extracts of both grains and brans revealed strong antioxidant properties by reducing Fe3+ (22.9% and 42.3%) and chelating Fe2+ (47.3% and 32.4%), respectively. Moreover, both extracts were found to inhibit the DPPH● radical, exhibiting an IC50 (μg/mL) of 31.34 and 36.48 respectively, as well as, to reduce Molybdate (VI) through the relative antioxidant capacity assay (IC50 of 330and 227.6μg/mL, respectively). They also inhibited the oxidative degradation of 2-deoxyribose (2-DR) provoked by the Fenton reaction by 29.60% and 17.77%, respectively. Furthermore, aqueous extracts of grains and brans chelated Fe+2 by 65.09% and 59.12% and inhibited the degradation of (2-DR) in the Fenton reaction by 17.18% and 10.67%, respectively. Overall, the results showed that the acetone / water extraction from the brans of sorghum showed the best antioxidant effects, via electron transfer, radical scavenging and metal chelating...
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Posted by admin on Feb 28, 2018 in |
Let G(V,E) be a simple connected graph. For an edge e=uv, mu(e) is the number of edges lying closer to the vertex u than v, analogously define mv(e). The edge version of PI index of a graph G is defined as .Nano-structured TiO2 has been widely used in various applications such as biosensors, solar cells and biomaterials. Synthesis of nano-structured Titanium dioxide (TiO2) such as Nanotubes, Nano-wires and nano-fibers has raised interest lately due to their high surface to volume ratio and the ability of provoke a greater degree of biological plasticity compared to conventional microstructures. Nano-structured TiO2, has been widely used in various applications such as biosensors, solar cells, photocatalysis, phoelectrolysis and biomaterials. In this paper, we compute the edge-PI index of Titania Nanotubes...
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Posted by admin on Feb 28, 2018 in |
In the present study we have done non-targeted analysis of extract from Hamelia patens Jacq. by GC/MS and estimated the inhibitory concentration (IC50) of the extract in three human tumor cell lines MCF-7, H-460 and SF-268. Hamelia patens is an herbaceous perennial plant of family Rubiaceae. Parts of the plant are used in Peruvian and Mexican folk-medicine. Dried leaves of Hamelia patens were extracted for alkaloid. The extract was named HPAE and the yield was 1.76% (w/w). Non-targeted GC/MS analysis of HPAE was performed using Shimadzu QP 2000 GC, equipped with a ULBON-HR-5 capillary column and mass spectrometer as detector. The cancer cell lines were obtained from National Centre for Cell Science, Pune. In-vitro cytotoxic activity of HPAE on cancer cell lines were conducted by MTT assay. The GC/MS analysis of the HPAE enabled the identification of 44 compounds and IC50 of HPAE in MCF-7, H-460 and SF-268 were found to be 8.42 ± 1.16, 90.40 ± 18.48 and 91.47 ± 19.74 µg/ml, respectively. The HPAE was found to...
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Posted by admin on Feb 28, 2018 in |
Introduction: Neurodegenerative diseases are incurable and debilitating condition that results in progressive degeneration and / or death of nerve cells. Anti-oxidants, Antihyper-glycemics and insulin sensitizing agents are reported for reducing cognitive dysfunction in diabetes. Decreasing GLP-1 degradation using Dipeptidyl Peptidase-4 (DPP-4) inhibitors has been shown to be effective for treating type-2 diabetes and neurodegeneration. Objective: In present study neuroprotective effect of sitagliptin and saxagliptin on streptozotocin induced neurodegenerative mice had been evaluated. Materials and Methods: Neurodegeneration was induced by single dose of Streptozotocin (120mg/kg I.P) and started drug treatment (Sitagliptin and Saxagliptin) after 28 days of Streptozotocin single dose treatment for next 21 days. Streptozotocin induced memory decline was confirmed by behavioural study and Inflexion Ratio – IR. Results: Memory decline was overturned by Saxagliptin (0.5 and 1mg/kg p.o) and Sitagliptin (10 and 20mg/kg p.o). In addition to above, Saxagliptin (1mg/kg p.o) and Sitagliptin (20mg/kg p.o) had reversed levels of dopamine, nor-adrenaline and serotonin in brain as compared to only Streptozotocin treated animals, suggesting neuroprotective activity of chosen two...
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