Posted by admin on Jun 30, 2018 in |
The author has been proposed the precolumn derivatization method for the trace level quantification of cypionyl chloride in testosterone cypionate, it maybe potential impurity in the testosterone cypionate, it has to quantify in the testosterone drug Substance. The method development of cypionyl chloride has been started with gas chromatography with FID detector. The detection of cypionyl chloride was very poor and detection was less even for derivatization with 2-butanol in GC-FID detector. The GC-MS Electron impact ionization detector with derivatization by 2-butanol was developed and validated for trace level quantification of cypionyl chloride in Testosterone cypionate. The LOQ of this method was 1.7 ppm and the LOD was 0.6 ppm. The validation parameters were done against the ICH Q2 R1 guidelines. The precision, linearity, accuracy and solution stability was met the ICH Q2 R1...
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Posted by admin on Jun 30, 2018 in |
Lichens came as a consortium of two distinct and dissimilar components- the mycobiont and the phycobionts, which were defined as a composite organism. Lichen vegetation in India is dominated by more than 2500 species. Lichen secondary metabolites specially the phenolics, depsides and depsidones are unique in their origin and are found nowhere else. Much attention has been paid on the biological roles of lichen secondary substances in the recent past; which have been found to possess a lot of bioactivities, such as anti-tumor, antibacterial, antifungal, antiviral, anti-inflammatory and antioxidant activities. The present study aims on the bactericidal activity of lichen, Cladonia scabriuscula, collected from the Gopeshwar, Uttarakhand in the Western Himalayas. The 50% v/v ethanolic extract (CSE) extracted through cold extraction method was tested for its bactericidal potential against prevalent water borne pathogen and its antioxidant potential through CLSI protocol. The CSE was found active against E. coli and S. typhimurium with MIC 2.48 and 1.02 mg/ml respectively; while the FRSA IC50 was 0.625...
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Posted by admin on Jun 30, 2018 in |
Worldwide diabetic patients are very common. This paper studies spread of diabetes in human living in Lahore, Pakistan. Data is collected from two local hospitals of Lahore and TOPSIS is applied to draw the results of the study. The study points out the people who are more likely to have diabetes due to various parameters like age, weight, height, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), urinary creatinine, albuminuria and albumin creatinine ratio (ACR)...
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Posted by admin on Jun 30, 2018 in |
The architecture of cocoons and the chemical compounds present in the cocoons play crucial role to provide protection of the pupae during metamorphosis. Insects spin a silk web as cocoon to facilitate protection and ensuring proper inner environment inside the cocoon during the metamorphosis. Such cocoons are equipped with a variety of chemical compounds which include antibacterial, antifungal, insecticidal and insect repellent etc. Tasar silk worms are wild silkworms grown on forest trees for their commercial value, are subject to harsh environmental conditions in comparison with domesticated Bombyx mori silk worms. In this study antimicrobial compounds were screened from Indian tropical wild tasar cocoons by Fourier transform infrared spectroscopy (FT-IR), Fourier transform-Raman spectroscopy (FT-Raman), Gas chromato-graphy- Mass spectrometry (GC-MS) and identified the chemical compounds by NIST05 MS Library. The wild cocoons possess active alcoholic and phenolic compounds, aromatic organic acids, alkaloids, fatty acids and their derivatives for various protective functions. This chemical defence strategy of wild cocoons was confirmed by evaluating the antimicrobial potential of methanolic extract of Antheraea...
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Posted by admin on Jun 30, 2018 in |
Experiments were performed to design, develop and characterize bilayer buoyant tablets with Tramadol (TH), immediate release layer and Pregabalin (PGB), sustained release layer. Super disintegrants like crosscarmellose sodium and sodium starch glycolate, for IR layer where as Hydroxypropyl methylcellulose (HPMC-K4M, HPMC-K100M) and sodium carboxymethyl cellulose, as sustaining polymers for SR layer and sodium bicarbonate which liberates carbon dioxide for adequate buoyancy, was used in the bilayer tablet. FT-IR and DSC studies were conducted to evaluate drug and excipients compatibility. A full two level factorial experimental design was used for sustaining PGB release from buoyant SR layer. More than 90% of Tramadol was released from IR layer within 30 min. Diffusion exponents (0.36-0.55) and (T50%) time required for dissolving 50% of drug (1.96-3.31h) was determined for all SR tablet formulations. Optimised (S4) formulation exhibited 95.28% PGB released over 12 h. Since neuropathic pain is very difficult to treat, a delivery system for combination pharmacotherapy containing immediate releases of TH a unique powerful painkiller to provide instant pain relief and sustained...
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