Posted by admin on Mar 31, 2018 in |
Coconut shell oil was extracted from raw coconut shells, collected from Thiruvallur District. These were extracted using various solvents based on the polarity which includes ethanol, chloroform, acetone, petroleum ether and aqueous. The antibacterial activity against the growth of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Salmonella typhi was done. The antifungal activity against the growth of organisms such as Epidermophyton floccosum, Aspergillus niger, Penicillium, Microsporum canis, Candida albicans and Aspergillus flavus were tested. The extracts were compared with standards like novobiocin, amoxillin and ketoconazole for antibacterial and antifungal activity respectively. The results indicate that zone of inhibition increased when increasing the concentration of the extracts. Among the five extracts of coconut shell oil the ethanolic extract exhibited maximum antibacterial activity against six bacterial strains. Ethanol and petroleum ether extract showed maximum inhibitory activity against Epidermophyton and Candida albicans. This study showed that coconut shell oil possesses antimicrobial...
Read More
Posted by admin on Mar 31, 2018 in |
Introduction: Menorrhagia that means excessive uterine bleeding is one the most common reasons that women refer to gynecological centers. Despite the use of “Quince paste” in Iranian Traditional Medicine (ITM) clinics, no studies have been done in this regard. Objectives: This study was carried out to investigate the effect of “Quince paste” on uterine bleeding in patients with menorrhagia. Materials and methods: This study was a clinical trial of before-after pilot study conducted on 35 patients aged 18-50 years suffering from menorrhagia. A tea spoonful of “Quince paste” after each meal was prescribed for two months. A pictorial form was completed to determine bleeding volumes and days as well as quality of life questionnaire before and at the end of the intervention. Results: Patients age was 33.8 ± 10.8 years and BMI was 28.94 ± 14.07. Bleeding score decreased significantly after two months of intervention (from 264.2 ± 198.9 to 125.8±155.9), (p<0.001). Quality of life score decreased significantly from 30.28 ± 5.73 to 22.02 ± 3 (p<0.001). Bleeding days...
Read More
Posted by admin on Mar 31, 2018 in |
Chronotherapeutic drug delivery systems have been recognized as potentially beneficial to the chrono-therapy (time optimized) of chronic diseases that display time-dependent symptoms. In pulsincap system, therapy can be optimized by tailoring the dosing schedule based on chrono-biological pattern. The safety and efficacy of the drug is achieved by coordinating the peak plasma concentration with circadian rhythm. People with rheumatoid arthritis, usually experience peak pain in the morning. The absorption kinetics of conventional dosage forms that have night time dosing indication is inadequate in the morning, when the need is more. Ketoprofen is a potent NSAID used to treat RA. In the present study, a modified pulsincap of Ketoprofen was developed and evaluated. Hard gelatine capsule bodies were treated with formaldehyde and are filled with best formulations of solid dispersion (β-cyclodextrin) for burst release and microsponge (ethyl cellulose) for sustained release after specific lag time attained by hydrogel plug. The filled capsules were completely coated with 5% CAP to prevent variable gastric emptying. The results indicated that formulated pulsincap of...
Read More
Posted by admin on Mar 31, 2018 in |
This study reports protective effect of Abelmoschus moschatus seed extract against sodium fluoride (NaF) induced alterations in behavior correlated with neurochemical changes in developing brain of rats. Excessive intake of fluoride during pregnancy cross the blood brain barrier (BBB) and cause adverse effects on neonatal development. As the BBB in fetuses, neonates and infants is immature, it cannot provide protection against the entries. The pregnant wistar rats were randomly categorized into six groups of five animals each. Group I is of control rats received normal tap water. Group II is NaF exposed group with 20 ppm (or 20 mgkg-1 body wt.) in their drinking water. Group III rats were treated with A. moschatus aqueous extract (AMAE) (300 mgkg-1 body wt./day/rat) along with NaF water (20 ppm). Group IV rats were treated with A. moschatus ethanolic extract (AMEE) (300 mgkg-1 body wt./day/rat) along with NaF water (20 ppm).Group V and VI rats were treated with AMAE (300 mgkg-1 body wt./day/rat), and AMEE (300 mgkg-1 body wt./day/rat) respectively. On 1st, 7th,...
Read More
Posted by admin on Mar 31, 2018 in |
The study sought to describe the pharmacognostic features for identification and quality control of closely related species Saba senegalensis (A. DC.) Pichon and Saba thompsonii (A. Chev.) Pichon (Apocynaceae), useful medicinal plants against inflammation and its related diseases in Ghana and West Africa. Macro-morphological, qualitative and quantitative microscopic features as well as physicochemical, fluorescence and phytochemical properties, and Thin Layer Chromatography (TLC) profile of leaves, stem and roots of both plants were determined using standard methods. The results showed both plants are climbers with lanceolate leaves and acuminate apices. The differences in their calcium oxalate contents, the hypostomatic nature of the leaves with different stomatal types and epidermal cells, histological features of their midribs and surface data determinations and TLC profiles of the parts under study present useful data for clearly distinguishing between the two species of Saba. All plant parts contained varying amounts of nutritional elements. To the best of our knowledge, this is the first time detailed descriptions of the pharmacognostic features of the leaves, stem and...
Read More
