Posted by admin on Jan 31, 2018 in |
Manilkara hexandra (Roxb.) [Synonym: Mimusops hexandra] belonging to family Sapotaceae is revealed to be endowed with antibacterial activity. Leaves, fruits, roots and barks of the plant are renowned for their medicinal values. Herbal gels have prevalence over conventional gels in piling up the therapeutic efficiency and narrowing down the side effects. The design of present study is to formulate and evaluate the herbal gel containing methanolic and hydro alcoholic leaf extract of Manilkara hexandra using varying concentration of carbopol 934 (1%, 1.25% and 1.5%). The physicochemical criterion of formulations like color, homogeneity, pH, viscosity, spreadability and drug content were determined. Diffusion studies were carried through Franz diffusion cell. Stability studies were accomplished as per ICH Guidelines for duration of 3 months. The result proffer that formulation with 1% gelling agent and 2.5% extract elicited better stability and henceforth optimized. Further optimized formulation was tested in vivo, for their skin irritability over a span of 7 days. The denouement claimed no skin irritation to the animals. The optimized gel was...
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Posted by admin on Jan 31, 2018 in |
Benzimidazoles are an important class of compounds with a wide spectrum of biological activity ranging from anti-hypertensive, anti-viral, anti-fungal, antitumor and anthelmintic activity. Benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical industry for drug discovery. Due to their special structural features and electron-rich environment, Benzimidazole containing drugs bind to a variety of therapeutic targets, thereby exhibiting a broad spectrum of bioactivities. Numerous benzimidazole based drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potential. A series of benzimidazole derivatives were synthesized by a single step process by reacting o-phenylenediamine and benzoic acid. The purity and structure confirmation of the synthesized compounds were done by TLC and 1H-NMR. The compounds were evaluated for anti-microbial, anti-fungal and antioxidant...
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Posted by admin on Jan 31, 2018 in |
Background: Metabolic derangement in term of glucose dysregulation, dyslipidemia, and electrolyte disturbances are the adverse reactions of beta-adrenoceptor blockers that limit their use. Aims: To investigate the effect of BARBs on the cardio-metabolic risk factors and platelet indices that play a role in accelerating the atherogenicity. Materials and methods: This observational clinical study was done in the Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriya University in Baghdad, Iraq from 1st August 2016 to 31st December 2016. A total number of 54 uncontrolled hypertensive patients were enrolled in this study. They grouped into Group I (n=25): hypertensive patients treated with angiotensin receptor blockers (ARBs) or angiotensin converting enzyme inhibitors (ACEIs), and Group II (n=29): hypertensive patients treated with beta-adrenoceptor agents in addition to the ARBs or ACEIs. The anthropometric, blood pressure, fasting serum glucose and lipid profile, and the platelet indices were determined. Results: Group II patients have significant low fasting serum glucose and non-significant high serum levels of triglycerides and cholesterol. Significant negative correlation between fasting serum triglycerides...
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Posted by admin on Jan 31, 2018 in |
Mesua ferrea Linn. (M. ferrea) is an endemic medicinal plant used for the treatment of inflammation, rheumatism, bronchitis, fever, headache, asthma and skin diseases. The aim of this study was to investigate the anti-inflammatory activities of 80% ethanol extract from stem bark of Mesua ferrea Linn. using animal models. Female Wistar albino rats weighing (150-200g) were used for the study. Anti-inflammatory activity test was done on rats at two different doses (100 and 200mg/kg) by using carrageenan induced paw edema, cotton pellet induced granuloma and formalin induced paw edema. The results showed that the 80% ethanol extract of stem bark (SBE) 200mg/kg and indomethacin (10mg/kg) exhibited significant reduction of edema in carrageenan induced rat paw edema 39.3 (p < 0.05) and 38.8% (p < 0.01) respectively at the end of 4 h. In cotton pellet granuloma test, SBE (200mg/kg) and indomethacin significantly reduced the wet (42.5 and 40.6% (p < 0.01)) and dry (46.7 and 42.8% (p < 0.01)) weight of the cotton pellet respectively, while in formalin induced...
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Posted by admin on Jan 31, 2018 in |
A simple stability indicating reversed-phase HPLC method was developed, validated and subsequently alkaline degradation kinetics are also determined for the estimation of Flavoxate Hydrocloride (FVH) present in pharmaceutical dosage forms. The proposed RP-HPLC method utilizes a LiChroCART – Lichrosphere 100, C18 RP column Hibar® (250 × 4 mm, 5 μm) in an isocratic separation mode with mobile phase consisting of methanol and water in the proportion of 50:50% (v/v), at a flow rate of 0.8 ml / min and the effluent was monitored at 315 nm. The retention time of FVH was found to be 2.92 min. Stability of FVH was investigated as per ICH – prescribed stress conditions including acidic, alkaline, thermal, oxidative and photolytic conditions. Significant degradation of FVH was observed under all studied stress conditions. A kinetic study was conducted to investigate the alkaline degradation of FVH at different temperatures; reaction rate constants, half-life times and activation energy were calculated. The described method was linear over a range of 1 – 300 µg/ml. The percentage recovery...
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