Posted by admin on Apr 30, 2018 in |
Delonix regia Rafin. belonging to family Fabaceae and subfamily Caesalpinioideae is flowering plant native to Madagascar and East Africa. Delonix regia reported to have anti-diarrhoeal, anti-inflammatory, antioxidant, hepatoprotective and antimicrobial activity. The present study was carried out to establish the pharmacognostical studies, physico-chemical parameters along with preliminary phytochemical screening of petroleum ether, chloroform, ethylacetate, acetone, methanol and aqueous extracts of Delonix regia Rafin. stem bark. The macroscopical and microscopical characteristics of drug powder were studied. The transverse section of stem bark indicated the arrangement of various cells in cork, cortex, phelloderm and pith region. The preliminary phytochemical screening of various extracts revealed the presence of carbohydrate, protein, glycosides, flavonoids, sterols, phenolic and tannin compounds. The physico-chemical parameters such as total ash, acid insoluble ash, water insoluble ash and sulphated ash (8, 2.005, 3 and 1.4 %w/w respectively), loss on drying (45 %w/w) extractive values, foaming index, swelling index and fluorescence analysis of stem bark powder were studied. These studies will be helpful to establish standards for quality, purity and...
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Posted by admin on Apr 30, 2018 in |
A new simple, sensitive, precise, accurate and stability indicating RP-HPLC method has been developed for the simultaneous determination of epalrestat and pregabalin in combined tablet dosage form. The chromatogram was achieved with STD Discovery column 250 × 4.6 mm, 5m and mobile phase containing 0.1% ortho phosphoric acid buffer and acetonitrile taken in the ratio of 45: 55 was pumped through column at a flow rate of 1 ml/min. temperature was maintained at 25 °C. The effluents were monitored at 244 nm by using PDA detector. The retention time of epalrestat and pregabalin were found to be 2.407 min and 3.272 min. The validation of the method was done according to the ICH guidelines for different analytical parameters. The method was found to be linear in the range of 37.5 – 225 µg and 18.75 – 112.5 µg/ml for epalrestat and pregabalin respectively. The assay of marketed formulation was determined and find with 99.22% and 99.07% w/v for epalrestat and pregabalin respectively. The stressed sample was analysed and this...
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Posted by admin on Apr 30, 2018 in |
Objectives: To assess clinical and histopathological patterns, causative drugs, causality, severity and cost of treating cutaneous adverse drug reactions (CADRs) among patients admitted in tertiary care teaching hospital. Methods: In a prospective hospital-based study over a period of one year (June 2015- June 2016), CADRs of patients admitted to the dermatology department were recorded. The data was subjected to descriptive analysis. Results: Of the total 39 cases, 24 (61.54%) were male and 15 (38.46%) were female. Maximum patients (48.7%) belonged to 21 – 40 years age group. On causality analysis, 23 cases (58.33%) were of probable type whereas 16 (41.02%) of possible type. Steven Johnson syndrome (46.15%), maculopapular drug rash (20.51%) and drug reaction with eosinophilia and systemic symptoms (15.38%) were common CADRs. There were total 55drugs which could account for observed CADRs mostly belonging to anti-epileptic (32.72%), anti-microbial (29.09 %) and NSAIDs (21.81%) classes. The most frequent offending drug was phenytoin (18.18%) followed by paracetamol (10.91%) and carbamazepine (7.27%). Maximum CADRs were of severe type (66.67%) but no...
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Posted by admin on Apr 30, 2018 in |
Antacids are the commonly prescribed drugs for treating gastroesophageal reflux disease (GERD). As these are manufactured and marketed by various multinational and local companies there is a need for evaluating the cost effectiveness and efficacy of these antacids as a matter of public concern. In the present study an attempt has been made to determine and compare the acid neutralization capacity of antacid preparations sold across various retail pharmacies in Vijayawada, Andhra Pradesh, India to find out unit cost and effectiveness of antacid with respect to its composition and manufacturer. Six different antacid suspensions manufactured by different companies were evaluated for the oraganoleptic properties, viscosity, pH and particle size and were compared with each other. Acid neutralizing capacity was determined by titrimetric method. Cost effectiveness was done by calculating the cost per ml of antacid and efficacy was evaluated based on acid neutralizing capacity of antacid preparation. Suspension Medicaine® having higher acid neutralization capacity (30.22 mEq) with unit cost Rs.0.52/ml was found to be the most effective brand as...
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Posted by admin on Apr 30, 2018 in |
The purpose of this study is to achieve colonic release of anti-inflammatory drug sulfasalazine used in the treatment of inflammatory bowel disease (IBD) to minimise side effects with a novel method of single capsule with bilayer coating. Sulfasalazine is an anti-inflammatory drug which acts topically on the inflamed colon to provide relief. In the present study a time and pH dependent colon targeted system was developed and evaluated. Liquisolid plug (LSP) of poorly water soluble drug sulfasalazine was prepared to enhance its dissolution rate and bioavailability. Sulfasalazine liquisolid plug was filled in acrylic polymer coated capsule. This capsule was subsequently coated with ethyl cellulose + HPMC (combination) and eudragit S 100. The eudragit S 100 prevented capsule disintegration in stomach and combination of ethyl cellulose and HPMC prevented capsule disintegration in small intestine. The design of formulation hence ensured colon targeted delivery of drug, preventing premature drug release in stomach or small intestine and enhanced dissolution rate potentiating probable enhancement in bioavailability. In vitro release studies were carried out...
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