Posted by admin on Feb 28, 2018 in |
Garcinia kola is a known herbal plant which is widely consumed for many ethnomedicinal uses. This study was aimed at determining the effect of ethanol extract of G. kola seeds on levels of hematological as well as blood indices of liver (aspartate transaminase, alanine transaminase, alkaline phosphatase, total protein, and albumin) and kidney function (creatinine and urea). Extract (50, 100, 200 or 300 mg/kg) was orally administered to different groups of rats (n = 6) daily for thirty days. Control animals were given vehicle (DMSO + distilled water, 2:1). Blood levels of the parameters mentioned above were measured at the end of extract treatment. Livers and kidneys of animals were removed and weighed and organ-to-body weight ratio was obtained. Extract had no effect on serum levels of liver and kidney indices, except that it reduced (P<0.05) ALP level at 300 mg/kg. Organ-to-body weight ratio of liver and kidney were not affected by extract. Furthermore, the extract increased (P<0.001) platelet count, but had no effect on RBC and its indices...
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Posted by admin on Feb 28, 2018 in |
The present study was approached to prepare SMEDDS loaded herbal drug (THDC4-0475RD) for the arthritis through topical delivery by gel formulation(s). The efficiency of prepared SMEDDS and SMEDDS loaded gel to enhance the delivery of anti arthritic drug were also evaluated. Labrafil and Stelliester were used as oil phase. Cremophor used as surfactant and sodium caprylate, cutina HR pH, Lutrol Micro127, Sepitrap 4000, GMS 40-PW-(SG) as co-surfactant. Formulations were optimized using pseudoternary phase diagram. The finalized formulations (F21 and F24) and the optimized formulation F36 were characterized for various parameters. It is concluded that the research proves, the formulated SMEDDS loaded with drug has increased the solubility of poorly water soluble THDC4-0475RD and thereby increases therapeutic efficiency. It fulfilled all the required criteria of a stable SMEDDS such as globule size, size distribution, in vitro diffusion study, and in vitro anti-arthritic study. The SMEDDS gel loaded with THDC4-0475RD would be effective against arthritis through topical...
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Posted by admin on Feb 28, 2018 in |
The present study focuses on the treatment of ocular inflammation with objectives of reducing the frequency of administration, obtaining controlled release and greater therapeutic efficacy of drug (Keterolac tromethamine) using ocular films. Various combinations were designed for different batches of ocular films as per factorial design study with 0.5 % w/v concentration by solvent evaporation method containing different combination of polymers such as HPMC K100M, ethyl cellulose, Carbopol 934 and PVP K30. The folding endurance and thickness of the films were in the range of 44±1.1to 92±1.8 and 4.5±0.6 to 6.8±0.3, respectively for different formulations. Surface pH was evaluated in the range of 6.6 to 7.2 for optimized formulations. % moisture absorption and % moisture loss were evaluated in the range of 1.17±1.1 to 6.72±1.5 and 0.58±0.9 to 1.23±0.9 respectively. No microbial growth was observed in any formulation during sterility testing by direct inoculation method. The drug release for prepared formulations of different batch codes PAH, PBE, PCP, PDC, PEEH & PFEC was found to be 93.3±1.1, 54.2±0.9, 92.3±1.2,...
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Posted by admin on Feb 28, 2018 in |
Antimicrobial activity of mycelia and Sporocarps has been adequately worked out but comparative studies of both has not done in detail. The present work is to compare the antimicrobial activity of mycelia and sporocarps of Entoloma speculum. It is a saprophytic, white fleshy fungi, belongs to Entolomataceae. The collected fruiting bodies were dried, powdered and subjected for secondary metabolites extraction. Mycelia was cultured by loading the spore loading the spore to potato dextrose agar plates. Mass culture of mycelia was done on patato dextrose broth (Shittu 2005) and was extracted by methanol. Both extracts were tested against pathogens, viz., Xanthomonas campestris, Pseudomonas syringae, Agrobacterium tumefaciens, Klebsiella pneumonia, Escherihia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Trichophyton rubrum, Chrysosporium keratinophilum, Fusarium solani, Penicillium chrysogenum, Aspergillus niger. Mycelial extract inhibited T. rubrum maximum (36 mm), Sporocarp inhibited F. solani at 28mm maximum, the mycelial extract inhibited pathogenic fungi and sporocarps extract inhibited bacterial...
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Posted by admin on Feb 28, 2018 in |
Objective: Nature has given ginormous resources to mankind since time immemorial. Amidst of various natural sources, products from plant origin endure more of commercial importance. Gums and resins are plant based reserves occupying a prime place among Non-Wood Forest Produce (NWFP). It is a most challenging aspect to isolate and characterise eco rich gums and resins from trees which can be widely used as a pharmaceutical aid in design of drug delivery system. Norfolk pine (Araucaria heterophylla) is an ornamental tree available abundantly in tropical and subtropical regions. Gum was obtained by extraction from the bark exudates of the tree. Method: The aim of the present study was to extract and characterise the gum obtained from Araucaria heterophylla. Phytochemical and physiochemical characteristics such as solubility, melting point, loss on drying, ash value, pH, swelling capacity, viscosity, particle size, shape and surface morphology, crystalline nature, flow property, bulk density, microbial contamination and in-vitro cytotoxic effect were determined. Results: Phytochemical evaluation showed the presence of reducing sugars and polysaccharides. The results...
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