Posted by admin on Jan 31, 2018 in |
Bisphenol A (BPA) is primarily used in the manufacture of plastics and resins. There are many scientific reports that point to the adverse effects of this chemical to different animal models. There has been an increase in use of plastic during the last couple of decades and this has increased human exposure to plasticizers like Bisphenol A. But since little is known on how these endocrine disruptors especially BPA promote cancer progression, the study investigated the effect of BPA on hepatocellular carcinoma cell line Hep-G2 by evaluating the expression of molecules involved in the processes of inflammation, cancer and angiogenesis. Cell viability studies using MTT assay, RT-PCR studies and Western blotting studies were performed to check effect of Bisphenol A on liver cancer cells. Cell viability studies, RT-PCR studies and Western blotting studies showed a dose dependent increase in the expression of factors involved in cancer progression which decreased when the cells were treated with Meloxicam, a COX-2 inhibitor. The results indicate that BPA up-regulates the expression of factors...
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Posted by admin on Jan 31, 2018 in |
In the present study eight novel 2-pyrazoline – amino pyrimidine hybrids have been synthesized in order to search new chemical entities with increased pharmacological properties. The targeted analogues were synthesized in four steps; Claisen-schmidt condensation of 4-nitro acetophenone with different benzaldehydes in basic medium to yield precursor chalcone which was cyclised using hydrazine hydrates and acetic acid to form 1-acetyl-2-pyrazoline. These were condensed with substituted benzaldehydes to give corresponding pyrazolyl chalcones, which were cyclised using guanidine carbonate to obtain 2-pyrazoline-amino pyrimidine hybrids. All the synthesized compounds were characterized by elemental and spectral (1H and 13C NMR, FTIR and Mass) analysis. All the compounds have been screened for their anti-bacterial activity against gram positive bacteria (Bacillus substilis, Streptococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and antifungal activity against Aspergillus niger comparable to reference standard ciprofloxacin and fluconazole by agar-well diffusion method. All compounds 4(a-h) exhibited moderate to high activity and showed more pronounced antibacterial activity than antifungal activity. 4h showed dual effect antibacterial as well as antifungal...
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Posted by admin on Jan 31, 2018 in |
Photochemoprotection has nowadays become inevitable to combat aging. Exposure to Ultraviolet radiations accelerates skin aging which eventually culminates in wrinkles, laxity, dyspigmentation, roughness and dryness. Though many active synthetic topicals have been used since years, the present era of treating an aged skin has been diverted towards natural biomaterials as these synthetic topicals pose health and safety risk on human health. In an effort to produce a promising natural anti-aging agent in contemporary cosmetics, this study has been aimed to formulate an anti-aging gel by blending three biopolymers namely Collagen (COL) 3%w/v, Chitosan (CS) 1.5% w/v and Aloe vera (AV) gel 0.21% w/v. The AV blended COL-CS gel was characterized by spreadability and moisture uptake test, which indicated good spreadability and increased hydrophyllicity of the gel. Cell culture studies on NIH3T3 mouse fibroblasts cells were carried out using senescence- associated-β-gal [SA-β-gal] as a biomarker. The fibroblasts cells on incubation with AV blended COL-CS gel showed increased proliferation rate and the absence of blue stain indicated that the process of...
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Posted by admin on Jan 31, 2018 in |
Curcuma longa nano powder was prepared by high energy ball milling equipment using green synthesis. Green synthesis is the process of synthesizing nanoparticle from biogenic resources based on the fact of its bioactive potential would be less toxic (product & bi-product), environmental safety (eco-friendly and biodegradable) cost effective and easily available to its natural origin. The powder was characterized by X-ray diffractometer (XRD), Scanning Electron Microscope (SEM), Fourier Transform Microscope (FTIR) and Photoluminescence spectrometer (PL).XRD and SEM results shows average crystalline size and grain size of turmeric powder are in nanometer range. Types of functional group and bond character in the nano powder were determined using FTIR. Optical properties of curcumin was includes changes the colour from yellow to red and emission of multicolour peak in visible region. In this approach, eco-friendly, rapid ways large amount of nano powder can be produced. Such nanometric food particles can improve the physicochemical properties of food materials. Since this materials also possess luminescence with nano size and hence may be useful in...
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Posted by admin on Jan 31, 2018 in |
Introduction: Patients with chronic kidney disease undergoing hemodialysis are usually co-morbid with hypertension that contributes to increased cardiovascular morbidity and mortality if not controlled. A number of factors are targeted as influencing agents to uncontrolled hypertension but adherence to treatment is counted as a major factor contributing to poor control of hypertension. Methods: A cross-sectional study was conducted at the renal unit amongst a sample size of 144 hypertensive patients aged 18 years and above, respondents were identified using simple random sampling. Data was collected using semi structured questionnaires. Data analysis using Chi square test was applied to establish significant relationships between the dependent variable (adherence) and independent variables (knowledge and perception), logistic regression was used to predict independent variables that influence adherence, and results with p values ≤ 0.05 were considered statistically significant. Adherence was determined using Morisky’s Medication Adherence Scale (MMAS-8). Findings: Overall, 83(57.6%) of the patients were found to have high adherence rate to their antihypertensive medication. Factors that influenced adherence to antihypertensive medication were; age...
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