Posted by admin on Mar 31, 2018 in |
Chronotherapeutic drug delivery systems have been recognized as potentially beneficial to the chrono-therapy (time optimized) of chronic diseases that display time-dependent symptoms. In pulsincap system, therapy can be optimized by tailoring the dosing schedule based on chrono-biological pattern. The safety and efficacy of the drug is achieved by coordinating the peak plasma concentration with circadian rhythm. People with rheumatoid arthritis, usually experience peak pain in the morning. The absorption kinetics of conventional dosage forms that have night time dosing indication is inadequate in the morning, when the need is more. Ketoprofen is a potent NSAID used to treat RA. In the present study, a modified pulsincap of Ketoprofen was developed and evaluated. Hard gelatine capsule bodies were treated with formaldehyde and are filled with best formulations of solid dispersion (β-cyclodextrin) for burst release and microsponge (ethyl cellulose) for sustained release after specific lag time attained by hydrogel plug. The filled capsules were completely coated with 5% CAP to prevent variable gastric emptying. The results indicated that formulated pulsincap of...
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Posted by admin on Mar 31, 2018 in |
This study reports protective effect of Abelmoschus moschatus seed extract against sodium fluoride (NaF) induced alterations in behavior correlated with neurochemical changes in developing brain of rats. Excessive intake of fluoride during pregnancy cross the blood brain barrier (BBB) and cause adverse effects on neonatal development. As the BBB in fetuses, neonates and infants is immature, it cannot provide protection against the entries. The pregnant wistar rats were randomly categorized into six groups of five animals each. Group I is of control rats received normal tap water. Group II is NaF exposed group with 20 ppm (or 20 mgkg-1 body wt.) in their drinking water. Group III rats were treated with A. moschatus aqueous extract (AMAE) (300 mgkg-1 body wt./day/rat) along with NaF water (20 ppm). Group IV rats were treated with A. moschatus ethanolic extract (AMEE) (300 mgkg-1 body wt./day/rat) along with NaF water (20 ppm).Group V and VI rats were treated with AMAE (300 mgkg-1 body wt./day/rat), and AMEE (300 mgkg-1 body wt./day/rat) respectively. On 1st, 7th,...
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Posted by admin on Mar 31, 2018 in |
The study sought to describe the pharmacognostic features for identification and quality control of closely related species Saba senegalensis (A. DC.) Pichon and Saba thompsonii (A. Chev.) Pichon (Apocynaceae), useful medicinal plants against inflammation and its related diseases in Ghana and West Africa. Macro-morphological, qualitative and quantitative microscopic features as well as physicochemical, fluorescence and phytochemical properties, and Thin Layer Chromatography (TLC) profile of leaves, stem and roots of both plants were determined using standard methods. The results showed both plants are climbers with lanceolate leaves and acuminate apices. The differences in their calcium oxalate contents, the hypostomatic nature of the leaves with different stomatal types and epidermal cells, histological features of their midribs and surface data determinations and TLC profiles of the parts under study present useful data for clearly distinguishing between the two species of Saba. All plant parts contained varying amounts of nutritional elements. To the best of our knowledge, this is the first time detailed descriptions of the pharmacognostic features of the leaves, stem and...
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Posted by admin on Mar 31, 2018 in |
The liver plays a significant role in metabolism and detoxification. Aponogeton natans(Linn.) Engl. and Krause is a important ingredient in preparation of an important Ayurvedic preparation Useerasava. The screening for hepatoprotective activity against carbon tetrachloride induced hepatotoxicity was followed as per standard procedure. Animals received CCl4 (2 ml/kg, 1:1 in olive oil, i.p.) to induce hepatotoxicity. Group I served as normal control and received the vehicle alone. Group II served as toxic control, Group III, IV, V, VI received 200 mg/kg of petroleum ether, benzene, chloroform, methanol extracts respectively and Group VII was treated with silymarin. The groups received the pre-treatment of A. natans extracts ANME and ANCE at dose levels of 200 mg/kg body weight significantly controlled the change in the biochemical parameters. The methanol extract (ANME) and chloroform extract (ANCE) at dose levels of 200 mg/kg exhibited significant increase respectively in the serum total protein level as compared to toxic control group and the effect was compared with the standard group treated with silymarin (Sily-100). The LPO,...
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Posted by admin on Mar 31, 2018 in |
The present study was conducted with the aim to prepare probiotics Lactobacillus acidophilus (L. acidophilus) granules which are stable at room temperature. Lactobacillus acidophilus 2285 probiotics was obtained from the N.C.I.M (National Collection of Industrial Microorganism), Pune. The formation of the semi-solid mass occurred after the further incubation at 34 °C from range (33 °C to 37 °C) in an incubator kept for the less than 24 hour time duration. This mass was homogenized and converted into granule formulation. The viability of the granule formulation was achieved with a maximum viable cell count after 24 hours of incubation in de Man, Rogosa, and Sharpe (M.R.S) agar media. Spray dried and tray dried powder of the probiotics is used for granulation, these drying methods served as a cheap alternative to the expensive freeze-drying procedure. The selected strain of L. acidophilus NCIM 2285 assessed for antioxidant activity. The antioxidant activity of L. acidophilus was demonstrated by in-vitro test using 2, 2–diphenyl-1-picrylhydrazyl free radical scavenging assay. The results showed that intact cells and...
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