Posted by admin on Feb 28, 2018 in |
Objective: The main objective of the present work was to analyze the therapeutic potential of various fractions of ethanolic extract of Tecomella undulata Seem. heartwood in streptozotocin – nicotinamide (STZ-NA) induced diabetes in experimental rats. Materials and methods: Diabetes was induced in the experimental rats by injecting nicotinamide and streptozotocin intraperitonealy at an interval of 15 minutes. The diabetic rats were then treated with standard drug; metformin and different fractions of 70% ethanolic extract of heartwood of Tecomella undulata for the 21 days. The animals were estimated for the different biochemical parameters which included liver function test, kidney function test and total lipid profile of experimental animals. Histopathological studies were also carried out on the liver and pancreas tissue sections. Results: All the fractions exhibited a reduced blood glucose level but the best results were revealed by acetone fraction as is indicated by statistical data. All fractions depicted a positive approach to normalize the altered biochemical parameters of kidney, liver and heart organs of diabetic animals. Thus it indicats...
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Posted by admin on Feb 28, 2018 in |
The plant Rouwolfia tetraphylla has been used traditionally as antihypertensive and has been proven scientifically to possess high antioxidant and hepato-protective activity. This study was designed to check the potential of medicinal plants in treatment of hypertension which will be helpful to reduce the side and adverse effect of allopathic antihypertensive drugs. During the experimental period, 1% sodium chloride solution was administered orally with drinking water for four weeks and DOCA – salt (20 mg/kg body weight) was injected subcutaneously to elevate the systolic, diastolic and mean arterial blood pressure. The rats were then treated with the methanolic extract of Rouwolfia tetraphylla and a significant decrease in the systolic pressure was recorded. Biochemical assays including serum urea, serum creatinine, triglycerides, cholesterol, blood glucose and serum protein were also performed to assist the hypothesis. The study thus, concludes the anti-hypertensive activity of Rouwolfia tetraphylla in the DOCA – salt hypertensive wister...
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Posted by admin on Feb 28, 2018 in |
Eclampsia and Pre-Eclampsia is an acute and life-threatening complication during pregnancy. Hydralazine hydrochloride is one of the drugs of choice in treating this condition. The purpose of the present research work was to formulate the Mouth Dissolving Tablets by using different methods and provide a suitable patient convenience dosage form to enhance the bioavailability and provide quick onset of action. Formulation of MDTs of Hydralazine hydrochloride were prepared by using various superdisintegrants like cross-povidone, cross-carmellose sodium and sodium starch glycolate by direct compression method and camphor as an excipient by sublimation technique. Among all the formulations F9 and SF9 showed effective percentage of drug release at 12 minutes indicating faster and maximum absorption at the site of...
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Posted by admin on Feb 28, 2018 in |
Free radicals are atoms or groups of atoms with an unpaired number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction, like dominoes. These free radicals become more lethal when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. Free radicals play a crucial role in a complex interplay of different mechanisms in both normal ageing and neurodegenerative diseases. Free radicals and other reactive oxygen species are generated continuously via normal physiological processes, more so in pathological conditions. The different solvent extracts of Evolvulus alsinoides at different concentrations i.e. 0.1mg/ml, 0.2 mg/ml, 0.4 mg/ml, 0.6 mg/ml, 0.8 mg/ml and 1.0 mg/ml showed significant in-vitro antioxidant activity DPPH (2, 2-diphenyl -1- picrylhydrazyl) assay and hydrogen peroxide scavenging assay against standards L-ascorbic acid and Butylated hydroxytoluene (BHT) respectively. Therefore, the EC50 values for DPPH assay are EEA=196.08±2.16 μg/ml and HAEA=307.66±1.72 μg/ml and for hydrogen...
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Posted by admin on Feb 28, 2018 in |
In this study, the stomach environment of paracetamol and metaclopramide active substances was prepared with the aid of chemometric method and UV spectrophotometer and their concentrations were measured at certain ratios. Spectra of these two active substances were observed separately in UV spectroscopy at different concentrations. Spectra of paracetamol and metaclopromide were observed by UV spectroscopy at certain ratios and concentrations. These observed spectra gave us an idea by using the chemometric method to generate numerical data indicating whether these two drugs should be used together. Absorbance and concentration values were used in Minitab and other chemometric programs to calculate estimated concentrations with PCR and PLS. In the first step, the synthetic mixtures including paracetamol and metaclopromide were prepared and absorbance values are obtained from spectrophotometry. The second step, in drug tablets (Parol and Metpamid) was calculated amounts for paracetamol and metaclopromide. Because of recovery and standard deviation were accomplished, this study encouraged us to applied for drug...
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