Posted by admin on Mar 31, 2018 in |
Buckwheat has been a major food source in Asian countries such as China, Japan, and Bhutan etc. for its nutritional values. It has been a major functional food supplement for nutraceutical industry. It is the first time exploration of buckwheat seed powder as tablet binder. The aim the study was to expand the area off tablet binders from gums and extracted polysaccharides to whole seed powders so as to reduce processing cost involved with other synthetic binders and involvement of whole seed benefits to single dosage form. In the present study buckwheat seed powder was used in the concentrations of 1%, 2%, 4%, 6% and it was compared with binding capacity of 2.5% acacia in tablet formulation as direct compressible agent. Valsartan was used as a model drug. It was found out that 2% w/w concentration of Buckwheat seed powder performed well and all the parameters were in good range. It was concluded that buckwheat seed powder can be a good direct compressible agent for tablet...
Read More
Posted by admin on Mar 31, 2018 in |
Metals are able to form a large number of oxides. These metal oxides play an important role in many areas of chemistry, physics and material science. An important metal oxide known as magnesium oxide (MgO) having good reactivity is widely used in producing electronics, catalyst, ceramics, oil, paint etc. Magnesium oxide nanoparticle is non-toxic and need a small amount, so it is suitable for the development of flame-retardant fiber additives. In addition, nano magnesium oxide added in fuel can inhibit corrosion. Spherical shaped Magnesium oxide nanoparticles were successfully synthesized by sol-gel technique at room temperature using magnesium nitrate and sodium hydroxide as a precursor. The morphological investigation of MgO nanoparticles was done by various analytical techniques. X-ray Diffraction (XRD) indicates the crystallinity and crystal size of MgO nanoparticle. Transmission electron microscopy (TEM) tells about the particle size and morphology. Fourier transform infrared microscopy was used to get the infrared spectrum of the sample indicating powdered composition of the sample. UV-Visible spectroscopy was used to know the optical properties of...
Read More
Posted by admin on Mar 31, 2018 in |
Objective: To determine the immunomodulatory activity of leaves of Rumex vesicarius Linn. and Symplocos racemosa Roxb. Methods: The ethyl acetate and ethanolic extract of Rumex Vesicarius Linn. and ethanolic and N-hexane extract of Symplocos racemosa Roxb. were administered orally at the dosage level of 200 mg/kg/day and 400 mg/kg/day each according to the body weight of Rat. The assessments of immunomodulatory activity were carried out by using Carbon Clearance Test and Delayed Type Hypersensitivity Test. Result: Oral administration of all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. significantly (P < 0.0001) showed an increase in phagocytic activity and DTH response in Rat at an experimental dose. The study also comprises the acute toxicity study and preliminary phytochemical screening. Conclusion: The study demonstrate that all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. shows the significant immunomodulatory effect on both humoral as well as cell-mediated...
Read More
Posted by admin on Mar 31, 2018 in |
In the present investigation, fluorescently labelled sulfated polystyrene beads were coated with oppositely charged polyelectrolytes {i.e. Poly diallyl dimethyl ammonium chloride, Poly (sodium 4-styrene sulfonate)} through an electrostatic interaction by using layer by layer assembly method. Doxorubicin is a model anticancer drug with protonatable amine group that acquires net positive charge in an acidic environment. The positively charged doxorubicin was electrostatically bound onto the surface of polystyrene beads coated with Poly (sodium 4-styrene sulfonate) as an outer layer. This model drug loaded nanocarrier was characterized by optical spectroscopy. In addition, gel electrophoresis principle was used to track the polyelectrolyte coating on the surface of the negatively charged polystyrene beads. The layer by layer method of coating drug molecule on the surface of polyelectrolyte coated nanoparticles was also confirmed with size and zeta potential measurements by using dynamic light scattering. The correlation between the movement of polyelectrolytes coated nanoparticles in gel electrophoresis and size of the nanoparticles measured by dynamic light scattering were also studied. The results suggest that layer...
Read More
Posted by admin on Mar 31, 2018 in |
Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin, followed by ring opening reaction of epoxy positioned at 1st and 2nd carbon in the chemical structure. It was characterized by NMR, seven -CH2 (position 10, 11, 9, 8, 6, 4 and 2) carbons present at negative side. Tertiary carbons are present at chemical shifts 39 ppm and 70 ppm (position at 7 and 3) and primary carbons are present at chemical shifts 10 ppm and 13 ppm (position at 14 and 12). Both primary and tertiary carbons were found on the positive side of the spectrum. From FTIR studies, peak corresponding to -OH stretch is observed at 3,391 cm-1 and the -OH bending is seen at 1,111...
Read More
