Posted by admin on Mar 31, 2018 in |
Ethanolic extract of the aerial parts of Thymus serpyllum was evaluated for antioxidant activity. As many diseases in today’s world are due to free radicals, finding antioxidants of herbal origin can lead to development of safe herbal medicines for these diseases. Hydroxyl radical scavenging method was used to evaluate the antioxidant activity of Thymus serpyllum in the present study. The results obtained from the study proved the hydroxyl radical scavenging activity of Thymus serpyllum. Ethanolic extract (99.9%) of aerial parts of Thymus serpyllum was prepared, dried and sent to Deshpande Laboratories Private Limited, Madhya Pradesh Bhopal (An ISO 9001:2008 Certified Drug Testing Laboratory) for analyzing hydroxyl radical scavenging activity. The results obtained from the study proved the free radical scavenging of the extract. The antioxidant effect of Thymus serpyllum can be largely attributed to its chemical constitution. Since Thymus serpyllum showed significant antioxidant activity, it can be developed into a safe herbal formulation useful in stress and stress related...
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Posted by admin on Mar 31, 2018 in |
The purpose of this study was to design and evaluate Amoxicillin trihydrate floating granules by melt granulation technique using Gelucire 43/01 and Campritol 888 ATO as lipid carriers. Polymers HPMC K4M and Ethyl Cellulose as release rate modifiers. The granules were evaluated by FTIR studies, differential scanning calorimetry, Scanning Electron microscopy, drug content, in vitro floating ability and in vitro drug release. The optimized formulation showed good floating ability and 98% drug was released in 12 h with both lipid carriers. The drug release from optimized formulations F3 and F9 followed zero order patterns and governed by Non-Fickian mechanism which was confirmed by the ‘n’ values of Koresmeyer Peppas equations. Formulations of Gelucire 43/01 had shown superior retardation and floating characteristics compared to that of Campritol 888 ATO. In conclusion, hydrophobic lipid, Gelucire 43/01 can be considered as an effective carrier for design of a multiunit floating drug delivery system of highly water – soluble drugs such as Amoxicillin...
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Posted by admin on Mar 31, 2018 in |
Introduction: The practice of emergency medicine has the primary mission of evaluating, managing and providing treatment to patients with unexpected injury or illness. The emergency department of a tertiary care unit of a developing country is faced with the problem of heavy patient load and a paucity of human and economic resources. So, this study was conducted with the objective of Studying pattern of drug use, safety, and direct cost of treatment. Material and methods: This prospective observational study was conducted at the Emergency Medicine department of P.D.U Government Medical College, Rajkot over a period of one month. Demographic data, average stay, diagnosis and complete prescription was recorded in case record form. The Cost of individual prescription was calculated. Adverse drug reactions were also recorded. Result: A total of 1939 drugs were used in 200 prescriptions, with an average of 9.69 drugs per prescription. The most common route of administration of drugs was found to be intravenous injection 54.7%. 65.39% drugs were prescribed by a generic name. 95.5% drugs...
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Posted by admin on Mar 31, 2018 in |
The solid dosage form is the easiest method of administering drugs for systemic effect. All dosages forms are made by two main components one is API and second is excipient. Excipient is present in bulk quantity and is required for binding the API. There are mainly two techniques uses for manufacturing the tablets (i) wet granulation (ii) direct compression. Wet granulation is a time consuming process, and direct compression technique is time saving, cheap and convenient for pharmaceutical industries. In direct Compression technique, microcrystalline cellulose powder properties are very versatile. There are many processes used for drying of MCC. Out of these, we evaluated MCC with three different type of drying process i.e. Spray dried (SPD), spin flash dried (SFD) and bulk dried. Different drying methods do not change the chemical parameters of microcrystalline cellulose, only difference being the physical attributes of the MCC powder, it’s morphology and it’s consequents flow properties which directly effect the tablet properties i.e. compaction, hardness and in-vitro disintegration among...
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Posted by admin on Mar 31, 2018 in |
Objective: To attenuates hyperglycemia-mediated oxidative stress and protects liver marker enzymes in Swiss albino mice. Material and methods: Hyperglycemia was induced in mice by single intraperitoneal injection of alloxan (150 mg/kg body weight). Three days after alloxan induction, the hyperglycemic mice were treated with Azadirachta indica orally at the dose of 200 and 400 mg/kg body weight daily for 28 days. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), billirubin, glucose were estimated. Antioxidant properties were assessed by estimating lipid peroxidation, SOD and catalase (CAT). Results and discussion: Azadirachta indica at the dose of 200 and 400 mg/kg orally significantly (P < 0.001) and dose-dependently reduced and normalized blood glucose levels as compared with that of alloxan control group. Serum biochemical parameters were significantly (P< 0.001) restored toward normal levels in Azadirachta indica treated mice as compared with alloxan control. Azadirachta indica treatment also significantly (P <0.001) decreased lipid peroxidation and recovered SOD level and CAT activity toward normal...
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