Posted by admin on Feb 29, 2024 in |
Introduction: Carcinoma cervix is the major health problem with increased morbidity and mortality. Around 60% of cases are diagnosed at an advanced stage, making the treatment more complex. Pap smear can able to detect precancerous and cancer of cervix along with infection and inflammatory pathologies making the clinician in timely and appropriate management. Objective: This study aims at detecting the prevalence of current trends of nonneoplastic and neoplastic lesions of cervix in patients who attending our tertiary care centre. Materials and Methods: This is a prospective study done in Srinivasan medical college and Hospital for a period of 6 months in patients who attended gynaecology department. Smears were made and stained with Pap stain after fixation in ethyl alcohol. Reporting was done based on the Bethesda system 2014. Results: Out of 500 cases, 495 cases (99%) were satisfactory for evaluation. Of these, 470 (94%) cases were negative for intraepithelial lesion/malignancy and 24 cases (4.8%) shown epithelial cell abnormalities. Nonspecific inflammation contributed 30.6% cases, infections like Bacterial vaginosis were seen...
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Posted by admin on Feb 29, 2024 in |
Plants have been an important source of medicine with qualities for thousands of years. The therapeutic effects in the plants are due to the chemical compounds there in. Cynodon dactylon (L) Pers commonly known as Bermuda grass belongs to the family Poaceae. In ethnomedicinal practices, the plant Cynodon dactylon used in the treatment of various diseases and has pharmacological actions. Its health and nutritional benefits are well documented but very little about its bioactive compounds. The present study was carried to identify the phyto-constituents present in the methanolic extract of Cynodon dactylon (L.) Pers by GC-MS analysis to ascertain its usage by the local community as a plant possessing medicinal properties. In total 68compounds were identified. The major constituents were furfural (2.33%), 3-aminopyrazine 1-oxide levoglucosenone (1.39%) tetetrapentacontane (2.47%), 9-octadecanoic acid (2.27%), n- hexadecanoic acid (7.5%), Neophytadiene (1.30%) and benzene propanoic acid (1.91%). The above findings supported the traditional use of Cynodon dactylon in various...
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Posted by admin on Feb 29, 2024 in |
Background: Neurological assessment of traumatic brain injury patients is of prime importance as it affects the therapeutic and prognostic decisions. GCS (Glasgow Coma Scale), a well recognised and often used scoring system in such cases has some drawbacks. We compared FOUR score (Full Outline of Unresponsiveness) with GCS with an objective to test its validity as an alternative to assess the severity of traumatic brain injury. Methods: This was a descriptive study, conducted on 70 patients admitted to the neurosurgical ICU of a tertiary hospital of a Medical college in Karnataka, India. In these patients, FOUR score and GCS were assessed at the time of presentation and serially thereafter up to a week. The predictive value and the correlation between full outline of unresponsiveness score and Glasgow Coma Scale was studied. Results: Most of the patients presenting with traumatic brain injury were males (84%) and belonged to younger age group of 18 to 30 years (48.6%). A statistically significant correlation was found between Full outline of unresponsiveness score and...
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Posted by admin on Feb 29, 2024 in |
Peptic ulcer disease (PUD) is increasing gradually in India as well as worldwide. Excess use of non-steroidal anti-inflammatory agents (NSAID) and lifestyle factors cause gastric mucosal damage. This study was designed to search out the gastro-protective efficacy of hydromethanolic extract of Ayapana triplinervis on different graded ulcers. Mild to severe grade of gastric ulcer has been developed by oral administration of IND at the doses of 10mg, 20mg and 40mg/kg body weight for 15 days. Gastric ulcer were assessed by elevation of ulcer score, ulcer index, pepsin activity and gastric volume in IND-treated groups in respect to control group. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) levels were elevated in IND-treated groups in respect to control due to withdrawal of prostaglandin and cyclooxygenase (COX-2) enzyme induced suppression. Significant protection in the levels of these ulcerogenic parameters were observed after the treatment of Ayapana triplinervis (200mg/kg) when compared with the standard drug omeprazole (20mg/kg). The important antioxidant enzymes activities were decreased but lipid peroxidation levels elevated in all the ulcerated groups(p<0.05)....
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Posted by admin on Feb 29, 2024 in |
Aurones constitute a less studied sub-class of flavonoides which occur rarely in nature. Aurones are responsible for the golden yellow colour of some flowers. Substituted 2-benzylidene-1-benzofuran-3 (2H)-ones are commonly known as aurones that belong to the naturally occurring flavonoids. In the present investigation, a series of some novel substituted 2-benzylidene-1-benzofuran-3 (2H)-ones (2a-j) have been synthesized by cyclization of 1-(substituted-2-hydroxy-phenyl)-3-(4’-dimethylamino-phenyl)-prop-2-en-1-one (2-hydroxychalcone) (1a-j) with mercuric acetate in DMSO. The products were tested for purity by TLC and structures of newly synthesized compounds were confirmed by physical data, IR, 1H NMR and Mass spectral analysis. All these newly synthesized compounds were evaluated for their antibacterial activity against four different pathogens such as Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis and antifungal activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergillus flavus, using Peniciline and Greseofulvin as standard drugs by agar cup method and Poison plate method,...
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