Posted by admin on Dec 31, 2017 in |
Objective and Background: To study the immunological activity of aqueous extract of Oxalis corniculata in Albino wistar rats and Swiss Albino mice. The Oxalis corniculata is an edible and a medicinal plant which is important to the food industry and may also have a significant role to play in health care. Material and Methods: The aqueous extract of whole plant of Oxalis corniculata was adminstered orally at the dose of 200mg/kg/day and 400mg/kg/day body weight. The assessments of immunomodulatory activity were studied by haemagglutination antibody titre, delayed type hypersensitivity, cyclophosphoamide neutropenia and carbon clearance test. Cyclophosphamide and Levamisole used as immunostumulating agent. Observation, Finding and Conclusion: Oxalis corniculata is of considerable importance to the food industry and also possesses a wide spectrum of pharmacological property of immunomodulation which are associated with its diverse chemical constituents, including flavonoids, alkaloids, polysaccharides, fatty acids, terpenoids, sterols, proteins, Vitamins, and minerals. Discussion and Importance: Immuno-modulatiom is a process which can alter the immune system of an organism by interfering with its functions; if...
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Posted by admin on Dec 31, 2017 in |
The aim of this study was to understand and study the role and effect of different concentration of sapodilla pectin as a binding agent in tablet formulations and also its on the effect on physical evaluation of suspension. For this purpose two model drugs paracetamol and ibuprofen were selected and granules were made by wet granulation using different concentration of pectin. The tablets were first tested for its micromeritics properties of the granules. After the formulation of the desired tablets, they were compressed and were tested for quality. While for suspension kaolin and sapodilla pectin were used in combination to form antidiarrheal preparation and was evaluated physicaly. It was found that the concentration of added pectin has an influence on both the micrometric properties of granules as well as on the dissolution profile of formulated tablets. Both the tablets showed increasing hardness and lowering of dissolution rate with the addition of increased amount of pectin. However the best formulation for paracetamol was F4 and F5 with 40 and 50...
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Posted by admin on Dec 31, 2017 in |
Cadmium (Cd) is a toxic heavy metal in the environment. The aim of this study was to investigate the potential effect of Cd on cholinergic and bioenergetic systems in three brain regions: cerebral cortex, cerebellum and hippocampus. The young albino rats (3 months) were exposed to low dose of Cd (1.5 mg/kg body weight) and high dose of Cd (3 mg/kg body weight) through intraperitoneal injection daily for a period of 3 weeks. A separate batch of rats were given α-tocopherol at a dose for a period of one week along with low and high dose of Cd. In this study, we observed that the AChE activity and ACh content in synaptosomal fractions and Mg2+-ATPase and Na+/K+-ATPase activities in mitochondrial fractions. We found the decrease in AChE, Mg2+-ATPase and Na+/K+-ATPase activities and increase in ACh content compared to control. The high dose of Cd treated rats showed maximal decrease in the AChE, Mg2+-ATPase and Na+/K+-ATPase activities and ACh content compared to low dose of Cd treated rats. The maximal...
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Posted by admin on Dec 31, 2017 in |
Osteoarthritis is characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth. The main causes of Osteoarthritis are abnormality in limb, in development of joint, hereditary factors, history of joint injury, stress etc. Conventionally analgesics are used to reduce the pain, inflammation, joint swelling and stiffness. But these drugs have many side effects like gastro intestinal irritation, nausea, ulcers or bleeding, fluid retention, hypertension, renal insufficiency etc. Curcumin acts as an inhibitor for COX, 5-LOX and glutathione S Transferase. It also lowers the production of histamine. Its anti arthritic action in combination with NSAID was screened in this study. Animals were divided into 5 groups. Group 1 was control group. Group 2 was disease control with the induction of arthritis using nalidixic acid 40mg/Kg subcutaneously. Group 3 was administered with standard drug Diclofenac sodium (13mg/Kg) orally. The group 4 received standard drug along with Curcumin (200mg/Kg orally). Group 5 animals received pretreatment with curcumin (200mg/Kg) before the induction of Osteoarthritis. Physical or...
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Posted by admin on Dec 31, 2017 in |
A health study was conducted in Northern Region of Bangladesh to determine the prevalence and cause of taking psychotropic drugs. The health survey was involved 615 patients who are taking psychotropic drugs and found 63.58% patient is male and 36.42% is female. The majority of patients are student (45.65%), housewife (19.02%) and service holder (13.33%). The age of patients is 15 – 24 years 35.93% and 25 -34 years 31.38%. Supreme cause of taking psychotropic drug is tension 25.37%, depression 18.21%, sleeping disorder 10.56% and pain 10.24%. The patients are taking anxiolytic drug (59.02%), antipsychotic drug (19.84%) and antidepressant drug (20.65%). The food habit of the patient’s shows that their preferred food is sour (16.26%), sweet (31.87%), spiced (23.58%), meat (47.97%) and soft drinks (30.41%). Among the patients, 31.06% are addicted to narcotics and 38.04% are smokers. It is alarming that about 35.77% of the patients are taking this type of drug without the concern of physician which might cause serious adverse effects. It also found that there is...
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