Posted by admin on Jun 30, 2024 in |
Cyamopsis tetragonoloba belongs to the family Fabaceae and has notable medicinal properties as it is used as a digestive aid. Guar Gum, which is a high molecular weight carbohydrate with multiple industrial applications, is also obtained from this plant. Methanolic extracts of C. tetragonoloba were obtained through reflux extraction to perform further experiments. Various experimental tests were carried out to understand the physicochemical, antimicrobial, and fluorescence properties of C. tetragonoloba. HPTLC and phytochemical profiles were also obtained. Preliminary phytochemical analysis showed the presence of alkaloids, flavonoids, saponins, steroids and triterpenes. Microscopy of the sample powder showed the presence of macrosclereids and thickened xylem vessels. The maximum antimicrobial activity of C. tetragonoloba was seen at a sample concentration of 10 µL where the activity was more than standard against Escherichia coli and Aspergillus niger. HPTLC profiling showed 7 bands each in 5 lanes of increasing concentration and a pattern unique to C....
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Posted by admin on Jun 30, 2024 in |
Symmetric peak and effective peak resolution in chromatography were achieved by adjusting the mobile phase’s pH and amount of organic Phase. The retention time of 2.127 and 4.145 minutes was observed after the elution of Bortezomib and Selinexor respectively. To accurately measure both Selinexor and Bortezomib at the same time, an approach was developed with an optimal wavelength of 236nm. Selinexor and Bortezomib were successfully separated by chromatography using a mobile phase of Acetonitrile: 0.1% Formic acid (30:70, v/v) and Luna Phenyl Hexyl (250×4.6mm, 5μ) column running at 1.0 ml/min. When looking at the linearity range, statistics correlating 0.999 indicates a very excellent correlation. For intermediate precision intervals, the relative standard deviation of Selinexor and Bortezomib, respectively, was 0.47 and 0.53, indicating the reproducibility of the analytical approach. The suggested analytical approach has a low LOD, which means that it is also extremely sensitive. This indicates that the suggested approach has sample accuracy by ICH requirements, as 99.9 and 100.2 percent of the spiking Selinexor and Bortezomib, respectively, were...
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Posted by admin on Jun 30, 2024 in |
A new, simple, and sensitive differential scanning calorimetry and infrared spectrophotometric technique was developed to estimate ethambutol hydrochloride in tablet dosage form. In the first method the concentration range of ethambutol hydrochloride was discovered to be 0.5 mg to 2.0 mg using differential scanning calorimetry (DSC), with the peak region of an exothermic thermogram at 75.8 °C and a continuous heating rate of 5 °K min-1. Second method which involves the measurement of ethambutol hydrochloride by Infra Red (IR) spectroscopy, the concentration range was determined to be 1.0 mg to 2.5 mg. The correlation coefficients for these techniques were determined to be 0.999 and 0.9919 for both DSC and IR methods respectively. The analytical results were statistically validated by the ANOVA technique and recovery trials. The recovery trials show no influence from other chemicals in the formulation. As a result, these two procedures are easy, precise, accurate and specific, and they might be employed for regular...
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Posted by admin on Jun 30, 2024 in |
The escalating use of medications among children presents a global concern, with self-medication by parents increasingly prevalent. This study investigates the prevalence of self-medication practices among parents of children aged 1 to 12. Methods: Over six months, 200 participants who self-medicated their sick children were enrolled. The study, conducted at King Koti District Hospital in Hyderabad, utilized a self-structured questionnaire targeting paediatric patients aged 0-12. Results: Most participants were parents aged 20 to 40 years, predominantly fathers (65.5%), with most having two children (36%) aged 2-4 years. Fever was the most commonly reported condition (22.5%). While a significant proportion expressed confidence in selecting over-the-counter (OTC) medications (41.5%), NSAIDs and analgesics were the primary choices. Safety perceptions varied, with 25% considering OTC medications generally safe and 13% entirely safe. Discussion: The study highlights parental awareness of risks associated with self-medication, notably allergic reactions (49.5%) and over dosage (57%). It provides insights into parental self-medication practices in paediatric care, emphasizing the need for tailored interventions and educational efforts on safe medication...
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Posted by admin on Jun 30, 2024 in |
Aim: This study aims to explore the potential of transdermal drug administration as a viable alternative to conventional medication delivery systems. Specifically, the focus is on the development and evaluation of transdermal patches containing Lamivudine and Stavudine for the treatment of AIDS. The overarching objectives include extending drug release duration, reducing administration frequency, and enhancing patient compliance. Material & Methods: The formulations under investigation are meticulously designed using a combination of HPMCK15M, PVPK30, and EC in varying ratios. The patches are subjected to a thorough assessment, encompassing critical parameters such as film thickness, tensile strength, and drug content homogeneity. The incorporation of Tween 80 and dimethyl sulfoxide as plasticizer and penetration enhancer is a key methodological consideration for optimizing the transdermal patches. Additionally, the study explores the impact of natural permeation enhancers, such as oleic acid, eucalyptus oil, and clove oil, on drug permeation and release kinetics. Results: The outcomes of the study reveal promising findings, with the transdermal patches exhibiting favorable characteristics, including optimal film thickness, tensile strength,...
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