Posted by admin on Jan 31, 2018 in |
Different plants of the Apocynaceae family viz. Alstonia scholaris, Calotropis procera, Rauvolfia serpentine, Hemidesmus indicus and Calotropis gigantean are traditionally being reported in ulcers treatments. The present study was aimed to validate the authenticity of correlationship of various phytoconstituents concentrations, antioxidant activity and urease inhibitory potential of the same. Various methods of antioxidant potential possess variable modes of deactivation of free radicals. Plants possess myriad of chemical entities, an effort has been made to assign antioxidant and urease inhibitory putativity to various classes of compounds. The Flavonoid content seemed significant for antioxidant as well urease inhibitory potential. Calotropis procera and Calotropis gigantean possessed 104.11mgRU/g and 97.34mgRU/g of flavonoids. The two exhibited 39% and 40% urease inhibitory potential respectively. The ferric reducing power and the β- carotene bleaching tendency were highest in both species of Calotropis genus. Pearson’s correlation coefficient between total flavonoids-urease inhibitory percentage, β-carotene bleaching – flavonoids and FRAP – flavonoids content was significant. So the plants of Calotropis genus have good potential for the management of ulcers,...
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Posted by admin on Jan 31, 2018 in |
A prospective, observational study was conducted among the 100 diabetic and 100 non-diabetic patients for a period of six months for the evaluation of prevalence, KAP (Knowledge, Attitude and Practice) and prescribing pattern of drugs to type 2 diabetic patients and to assess the risk factors of prevalence of diabetes among the non-diabetic patients. All information relevant to the study was collected from case records and by direct interview method. The data collected was analyzed by using statistical package for the social sciences (SPSS) version 17.0 software. The results showed that, majority of the patients were male, above 61 years age, literates, free from smoking and alcohol habits, had medium physical activity, family history of diabetes and had at least one co existing illness mainly hyper tension. Oral hypoglycaemics and anti-hypertensives were mainly prescribed. After counseling the KAP was improved significantly. Majority of the non-diabetic patients were male, 26 % had less than 35 years age, mainly non-vegetarian. The results showed that age and BMI with the risk had...
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Posted by admin on Jan 31, 2018 in |
Manilkara hexandra (Roxb.) [Synonym: Mimusops hexandra] belonging to family Sapotaceae is revealed to be endowed with antibacterial activity. Leaves, fruits, roots and barks of the plant are renowned for their medicinal values. Herbal gels have prevalence over conventional gels in piling up the therapeutic efficiency and narrowing down the side effects. The design of present study is to formulate and evaluate the herbal gel containing methanolic and hydro alcoholic leaf extract of Manilkara hexandra using varying concentration of carbopol 934 (1%, 1.25% and 1.5%). The physicochemical criterion of formulations like color, homogeneity, pH, viscosity, spreadability and drug content were determined. Diffusion studies were carried through Franz diffusion cell. Stability studies were accomplished as per ICH Guidelines for duration of 3 months. The result proffer that formulation with 1% gelling agent and 2.5% extract elicited better stability and henceforth optimized. Further optimized formulation was tested in vivo, for their skin irritability over a span of 7 days. The denouement claimed no skin irritation to the animals. The optimized gel was...
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Posted by admin on Jan 31, 2018 in |
Benzimidazoles are an important class of compounds with a wide spectrum of biological activity ranging from anti-hypertensive, anti-viral, anti-fungal, antitumor and anthelmintic activity. Benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical industry for drug discovery. Due to their special structural features and electron-rich environment, Benzimidazole containing drugs bind to a variety of therapeutic targets, thereby exhibiting a broad spectrum of bioactivities. Numerous benzimidazole based drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potential. A series of benzimidazole derivatives were synthesized by a single step process by reacting o-phenylenediamine and benzoic acid. The purity and structure confirmation of the synthesized compounds were done by TLC and 1H-NMR. The compounds were evaluated for anti-microbial, anti-fungal and antioxidant...
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Posted by admin on Jan 31, 2018 in |
Background: Metabolic derangement in term of glucose dysregulation, dyslipidemia, and electrolyte disturbances are the adverse reactions of beta-adrenoceptor blockers that limit their use. Aims: To investigate the effect of BARBs on the cardio-metabolic risk factors and platelet indices that play a role in accelerating the atherogenicity. Materials and methods: This observational clinical study was done in the Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriya University in Baghdad, Iraq from 1st August 2016 to 31st December 2016. A total number of 54 uncontrolled hypertensive patients were enrolled in this study. They grouped into Group I (n=25): hypertensive patients treated with angiotensin receptor blockers (ARBs) or angiotensin converting enzyme inhibitors (ACEIs), and Group II (n=29): hypertensive patients treated with beta-adrenoceptor agents in addition to the ARBs or ACEIs. The anthropometric, blood pressure, fasting serum glucose and lipid profile, and the platelet indices were determined. Results: Group II patients have significant low fasting serum glucose and non-significant high serum levels of triglycerides and cholesterol. Significant negative correlation between fasting serum triglycerides...
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