Posted by admin on Mar 31, 2018 in |
Differences in cost and similarities in the efficacy between ondansetron and granisetron have been reported in many clinical studies and prompted this study to determine whether such differences are important as Kenyatta National Hospital. Thirty-four adult cancer patients scheduled to start their consecutive three weekly cycles of cisplatin-based chemotherapy regimens, were recruited into a double-blind randomized crossover study to receive ondansetron 12 mg or granisetron 3 mg each combined with dexamethasone 8 mg as intravenous on the first day and continued on their respective oral combinations from day 2 to 4. The frequency of nausea and vomiting were recorded daily during 5 days of antiemetic treatment. Data were collected using a close ended questionnaire and statistical analysis was performed using STATA version 13 software. Statistical significance was checked using Fisher’s exact test and was considered when p value was less than 0.05. Female predominance was 70.6%, while dominant age was 50-70 years at 47.1% with a mean age of 53.5 (± 11.9) years and cervical cancer was leading cancer....
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Posted by admin on Mar 31, 2018 in |
Donepezil hydrochloride is United States Food and Drug Administration (USFDA) approved drug marketed under the trade name “Aricept” used for the treatment of mild to moderate alzheimer disease. The aim of the current investigation was Kinetic and mechanistic study of donepezil hydrochloride by sodium-N-chloro-p-tolunesulfonamide or chloramine-T (CAT) in NaOH medium was studied at 308 K. the reaction follows first order dependence on [CAT]0, fractional order dependence on [substrate]0, and [OH–] ion concentration. Variation of ionic strength and addition of toluene sulfonamide have no significant effect on the rate. The reaction was studied at five different temperatures; however, the thermodynamic parameters have been assessed from the Arrhenius plots. The stoichiometry of the reaction has been established to be 1:1 and oxidation product 2-(1-benzylpiperdin-4-yl) methyl)-5-6-dimethoxy 3H-inden-1-ol was predicted by Chromatographic and Spectroscopic analysis. The observed results were supported by probable mechanism and the related rate law has been...
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Posted by admin on Mar 31, 2018 in |
A stability indicating method was developed for the estimation of Crizotinib in pharmaceutical dosage form by using Ultra Performance Liquid Chromatography (UPLC). The separation was done on isocratic mode with Hibra C18 (100 mm × 2.1 mm, 2 µ) column and 0.1% Ortho-phosphoric acid and acetonitrile (45:55% v/v) as mobile phase at a flow rate of 0.3 mL/min and at room temperature. The detection was done at a wavelength of 327 nm. A good linearity was observed in the concentration range of 37.5 µg/mL – 225 µg/mL, with a correlation coefficient of 0.999. The method was validated according to the ICH guidelines. The developed method was found to be accurate and precise, with % recovery 99.9% – 100.18% and % relative standard deviation 1.1. The drug was found to be stable at forced degradation conditions and the net degradation was found to be within the limits. The developed method can be used for the quality control of Crizotinib in pharmaceutical dosage...
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Posted by admin on Mar 31, 2018 in |
To establish authenticity and integrity for usage of herbal drugs quantitative analysis by sensitive analytical instrument is highly desirable. Quercetin and Kaempferol from whole plant of Moringa oleifera was chosen for simultaneous quantification by RP-HPLC and HPTLC method due to their pharmacological activities. HPTLC method of quercetin and kaempferol was developed on HPTLC plates using Toluene: Ethyl acetate: Chloroform: Formic acid (6:2:5:1.5) as mobile phase. Densitometric evaluation of flavonoids was performed at λ = 240 nm in absorbance mode. Furthermore, RP-HPLC method was developed using mobile phase containing acetonitrile and 0.1 M phosphate buffer (pH 2.5 adjusted by orthophosphoric acid) using C18 column in gradient mode. Chromatographic methods were validated as per ICH guidelines. Excellent linear relationships over the concentration range (1 – 40 µg/ml) were observed with the r2 value higher than 0.999 for both the phyto-constituents by RP-HPLC. Limit of detection and quantification were found to be in range of 0.2 – 0.5 µg/ml with percent recovery of 98 – 101%; while r2 value of quercetin and...
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Posted by admin on Mar 31, 2018 in |
Buckwheat has been a major food source in Asian countries such as China, Japan, and Bhutan etc. for its nutritional values. It has been a major functional food supplement for nutraceutical industry. It is the first time exploration of buckwheat seed powder as tablet binder. The aim the study was to expand the area off tablet binders from gums and extracted polysaccharides to whole seed powders so as to reduce processing cost involved with other synthetic binders and involvement of whole seed benefits to single dosage form. In the present study buckwheat seed powder was used in the concentrations of 1%, 2%, 4%, 6% and it was compared with binding capacity of 2.5% acacia in tablet formulation as direct compressible agent. Valsartan was used as a model drug. It was found out that 2% w/w concentration of Buckwheat seed powder performed well and all the parameters were in good range. It was concluded that buckwheat seed powder can be a good direct compressible agent for tablet...
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