Posted by admin on Oct 31, 2017 in |
A sensitive sensor for the electrochemical determination of anti-Parkinson’s disease drug; entacapone (EN) was constructed using carbon paste electrode modified via electro-polymerization of glycine (GL) incorporate gold nanoparticles (GNP) and sodium dodecyl sulphate (SDS). Different voltammetric techniques, electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM) techniques were used to characterize the properties of the modified electrode. The linear response was obtained for EN in the ranges of 4.1×10−7 to 0.5×10−3 mol L−1 with correlation coefficient 0.9990. The lower limit of detection was found to be 2.82 x10-9 mol L−1. The effectiveness of this sensor was established for the determination of EN in real samples. Also the simultaneous determination of EN with Levodopa LD and Carbidopa CD that are present in Stalevo tablets gives a good separated peak potential. Very low detection limit, simplicity of preparation and surface restoration, make the proposed modified electrode very useful for precise determination of EN either alone or in the tertiary...
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Posted by admin on Oct 31, 2017 in |
Usnic acid is lichen metabolite. Lichen species are the source of usnic acid. It has Antitumor and Anti-proliferation activity. Usnic acid is poorly water soluble drug. So its dissolution and bioavailability is poor. To enhance dissolution and bioavailability of usnic acid nanotechnology has been adopted. So in this study usnic acid powder was formulated as a nanoparticle with the help of PLGA polymer. Nano-precipitation with sonication method was adopted to formulate usnic acid loaded nanoparticles. Obtained nanoparticles were undergone to characterization and evaluation studies. SEM study revealed that particles are in the range of nanometer level and it is in spherical shape. FTIR and DSC studies have shown that no interaction between drug and polymer. In vitro drug release was maximum for optimized formulation. Optimized formulation also exhibited more antitumor activity than free usnic acid. Kinetic study revealed that the drug release is zero order. It concludes nano-precipitation with sonication is effective method for preparation of usnic acid loaded...
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Posted by admin on Oct 31, 2017 in |
Background: Iron deficiency anaemia poses a burden on the limited health care delivery system. Current pharmacological anti anaemic agents cause undesirable side effect like nausea, vomiting dark stool etc. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a food based extract prepared from plants products. Objectives: To assess the effectiveness of amla, jageery and pumpkin leaves mixture on level of haemoglobin, Vitamin C and iron among adolescent girls with iron deficiency anaemia. Method: An experimental design with pre-test and post-test control group was used for the study. Subjects were randomized to the control and experimental group. The intervention was administered to the experimental group. The blood test is used to estimate the haemoglobin, iron and Vitamin C. Results: There was significant difference observed in the pre-test and post test level of haemoglobin Vitamin C and iron of the subjects in the experimental group. In the experimental group there was a rise in mean values for haemoglobin from 9.942...
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Posted by admin on Oct 31, 2017 in |
The aim of the present article was to examine the protective effect of ferulic acid against liver cholestasis in female rats treated with ethinylestradiol (EE). The daily oral administration of the ferulic acid at a concentration of 40 mg/kg body weight for 15 days to rats treated with EE (100 µg/kg body weight for 5 days) resulted in a significant protection against EE-induced decrease in plasma cholesterol, bile acid, hepatic reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (Gpx), and catalase (CAT) levels as well as against an increase of plasma bilirubin, alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), malondialdehyde (MDA), 5′- Nucleotidase, interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α). The results clearly suggest that ferulic acid has a powerful prophylactic action in cholestasis induced by...
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Posted by admin on Oct 31, 2017 in |
The present work concern the production of activated carbon of reasonably good properties from cheep sources. The results of preparation of activated carbon from compressed wood sheets residues used in the furniture industry are presented. The preparation method entails the conversion of the wood sheets to a small size pellets and reacting these pellets with the activating agent FeCl3 (3% w/w). The mixture was heated at 300 oC for a period of 3 hours. The product was allowed to cool to room temperature, followed by carbonization at high temperatures with KOH. The effects of carbonization time periods of 3 and 12 hours and the ratios of wood pellets to potassium hydroxide (1:0.5, 1:1, 1:1.5 and 1:2) were investigated in order to determine the best operating conditions. The quality of the activated carbon produced was assessed by different methods such as density, humidity, ash content, iodine adsorption and the ability for methylene blue pigment removal from aqueous solution. The density of product decreases with increasing the carbonizing agent ratio. Humidity...
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