Posted by admin on Jan 31, 2018 in |
Objective: To evaluate in vitro antioxidant and anti-inflammatory activity of Cassia auriculata leaf extracts. Methods: Herbal extraction was done by Soxhlet extraction method with increasing polarity of Solvents viz., Chloroform, Ethanol, Methanol. Phytochemicals analysis was done using different biochemical tests. Antioxidant potential of plant extracts were analyzed by ferric ion reducing antioxidant power, phosphor-molybdenum and 2, 2-diphenyl-1-picrylhydrazyl, and anti inflammatory activity by using protein denaturation in vitro bioassay. Total phenolic content of each extract was also determined to assess their corresponding effect on antioxidant capacity of plant. Results: Phytochemicals analysis showed that each solvent extract contained broad spectrum of secondary metabolites, phenolic compounds, flavonoids, tannins and glycosides, where as compared to other solvent extracts, chloroform extract showed little quantity of phenolic Compounds, methanol extract exhibited the highest phenolic content and the significant Antioxidant capacity based on the test performed. Out of all extracts, methanol extract showed high anti-inflammatory activity. Conclusion: The present study revealed that different solvent extracts of Cassia auriculata leaves contain broad spectrum of bioactive compounds. Results...
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Posted by admin on Dec 31, 2017 in |
Highly substituted thiophene derivatives first synthesized by Gewald synthesis in 1965, are important heterocyclic compounds present in numerous biologically active compounds. The synthesis of title compounds was carried out by preparing derivatives of Gewald product. In the present study, a series of 2-aminothiophene derivatives were first prepared by Gewald reaction and further converted into 2-aminothiophene-1, 2, 4-triazole derivatives. Knoevenagel condensation of aryl ketones (1a-1d) with ethylcyanoacetate and subsequent treatment of the α-β-unsaturated nitriles (2) with sulfur and amine resulted in the corresponding 2-aminothiophenes (3a-3d), which were used as a starting material for the synthesis of substituted Gewald products. In the subsequent steps (3a-3d) were converted into carbohydrazides (4a-4d). Substituted carbohydrazides were then converted into potassium aryl carbonyl hydrazine carbodithionate (5a-5d) which were further converted into final compound 2-amino thiophene-1, 2, 4-triazole derivatives (6a-6d). The structures of all the synthesized compounds were confirmed by their spectral data (IR and 1H NMR...
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Posted by admin on Dec 31, 2017 in |
Solubility of drug is considered to be one of the crucial parameter to achieve its desired concentration in systemic circulation and better pharmacological response. As most of the drugs available are poorly aqueous soluble, solubility enhancement has become major challenge to the formulators in the product development of many orally administered drugs. Therapeutic response of drug as well bioavailability can be limited by poor aqueous solubility of drugs. Earlier, many techniques have been developed for enhancing solubility of drugs. Apart from those, hydrotropic solubilization is one of the solubility enhancement techniques applicable to enhance solubility of hydrophobic drugs with the use of hydrotropes like sodium benzoate, urea, piperazine etc. In the present investigation Lumefantrine, an anti malarial drug was selected as model drug for the reason it has very low water solubility of 0.009 mg/ml and belongs to BCS Class IV. The key objective of current research work was to enhance aqueous solubility of this drug using hydrotropic solubilization technique. Solubility studies were performed using various concentrations of hydrotropes...
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Posted by admin on Dec 31, 2017 in |
Objective and Background: To study the immunological activity of aqueous extract of Oxalis corniculata in Albino wistar rats and Swiss Albino mice. The Oxalis corniculata is an edible and a medicinal plant which is important to the food industry and may also have a significant role to play in health care. Material and Methods: The aqueous extract of whole plant of Oxalis corniculata was adminstered orally at the dose of 200mg/kg/day and 400mg/kg/day body weight. The assessments of immunomodulatory activity were studied by haemagglutination antibody titre, delayed type hypersensitivity, cyclophosphoamide neutropenia and carbon clearance test. Cyclophosphamide and Levamisole used as immunostumulating agent. Observation, Finding and Conclusion: Oxalis corniculata is of considerable importance to the food industry and also possesses a wide spectrum of pharmacological property of immunomodulation which are associated with its diverse chemical constituents, including flavonoids, alkaloids, polysaccharides, fatty acids, terpenoids, sterols, proteins, Vitamins, and minerals. Discussion and Importance: Immuno-modulatiom is a process which can alter the immune system of an organism by interfering with its functions; if...
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Posted by admin on Dec 31, 2017 in |
The aim of this study was to understand and study the role and effect of different concentration of sapodilla pectin as a binding agent in tablet formulations and also its on the effect on physical evaluation of suspension. For this purpose two model drugs paracetamol and ibuprofen were selected and granules were made by wet granulation using different concentration of pectin. The tablets were first tested for its micromeritics properties of the granules. After the formulation of the desired tablets, they were compressed and were tested for quality. While for suspension kaolin and sapodilla pectin were used in combination to form antidiarrheal preparation and was evaluated physicaly. It was found that the concentration of added pectin has an influence on both the micrometric properties of granules as well as on the dissolution profile of formulated tablets. Both the tablets showed increasing hardness and lowering of dissolution rate with the addition of increased amount of pectin. However the best formulation for paracetamol was F4 and F5 with 40 and 50...
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