Posted by admin on Dec 31, 2017 in |
The health and nutritional status of school children is an index of national investment in the development of its future manpower. Malnutrition affects the child’s physical and cognitive growth and increases the susceptibility to infections while having an adverse impact on economic growth of the country indirectly. The objective of this study is to assess the nutritional status of rural and urban school going children (16 – 18 years) of Bankura district, West Bengal. A total of 80 school children [rural school children (Group 1; n = 40) and urban school children (Group 2; n = 40)] belonging to the age group of 16 to 18 years and the study were conducted from the month of September 2015 to February 2016. The important clinical signs like pallor, hair changes, eye changes, teeth changes, skeletal changes, goitre, skin changes and bones etc., were found significantly higher for Group 1. Mean height, weight and body mass index were significantly higher in the Group 2 school children compared to Group 1. The...
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Posted by admin on Dec 31, 2017 in |
Poor aqueous solubility is the main problem in development of effective formulation which affects stability and bioavailability of drug formulation. So there is need of systematic formulation approach to make such poorly soluble drugs bioavailable. In the present investigation attempt has been made to investigate the effect of soluplus on solubility of gliclazide by preparing its nanocrystals. Nanocrystals of gliclazide with soluplus were prepared by using drug: carrier ratios of 1:0.5, 1:1, 1:2, 1:4, 1:6 and 1:8 by anti-solvent precipitation technique. Physiochemical analysis demonstrated the crystalline nature of particles and amongst all formulations 1:2 ratio provided the highest degree of gliclazide solubility i.e., 2.5027±0.77mg/ml as compared to pure drug 0.4918±0.51mg/ml. This increase in solubility may due to increase in surface area and or characteristics of nanocrystals and soluplus. The prepared nanocrystals were characterized by Fourier Transformed Infrared Spectroscopy (FTIR), Differential Scanning Colorimetry (DSC), X-Ray Diffraction pattern (XRD), Scanning Electron Microscopy (SEM). The prepared nanocrystals with highest solubility was formulated into tablet and evaluated for hardness, friability, drug content, disintegration...
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Posted by admin on Dec 31, 2017 in |
Aim of the study: This study evaluates the analgesic, anti-inflammatory and antipyretic activities of the aqueous, methanol and n-hexane extracts of Trichosanthes dioica Roxb. to provide experimental evidence for its traditional use such as fever, pain and inflammation. Materials and methods: Investigations on the analgesic effects of Trichosanthes dioica Roxb. was carried out by acetic acid-induced writhing using Aspirin as standard. The anti-inflammatory activity was observed by carrageenin-induced edema of the hind paw of rats using indomethacin as standard. The antipyretic activity was observed by yeast induced pyrexia in rat using Paracetamol as standard. Results: It has been shown that the methanol and aqueous extracts significantly reduced acetic acid-induced writhing response in mice. The methanol and aqueous extracts remarkably inhibited the increase in vascular permeability induced by acetic acid and also significantly decreased the carrageenin-induced rat paw edema perimeter. The methanol and aqueous extracts also shows reduction of body temperature in yeast induced pyrexia in rat model. Conclusion: The results show that the methanol and aqueous extracts have analgesic...
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Posted by admin on Dec 31, 2017 in |
Phenolic extracts of crude oil and methanol extracts of defatted seed cake were used to evaluate total phenolics, flavonoids content and antioxidant activity for two locations. The seeds were evaluated for their proximate composition while oils were subjected to chemical analysis. Salvadora persica had highest phenolics ranged from 12.3 ± 0.3 to 22.3 ± 0.3mg GAE/g and flavonoids content 3.7 ± 0.6 to 6.2 ± 0.2mg CAE/g. The antioxidant activity having IC50 value ranged from 0.024 ± 0.0 to 0.045mg/ml. The highest oil content as 42.5 ± 0.4% and highest protein content was 23.3 ± 0.3%. The oil content of the seeds recorded the highest iodine value 112.0 ± 0.8g/100g. The seeds were found to be rich in Ca, K, Na and P. The dominant fatty acids found in the oils were myristic and palmitic...
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Posted by admin on Dec 31, 2017 in |
This study was conducted to evaluate the antimicrobial and cellular metabolic inhibitory properties of the ethanolic extract from the bark of ‘Lunas-bagon’, Lunasia sp. Extracts were evaluated using the agar well diffusion method for antimicrobial assay. The standard phytochemical screening was done for the determination of compounds that can be considered toxic and MTT assay for the effects of the extract on cellular metabolism. Results showed that the extracts have ability to inhibit selected Gram-positive and Gram-negative bacterial isolates indicating that the extracts are effective antibacterials. Results from the MTT assay revealed at doses lower than 100.0 ug/ml, extracts will not inhibit cellular metabolism of the splenocytes. Higher dose, however shows reduction of metabolic activity which may indicate the onset of apoptosis in cells. Basic biochemical tests indicated the absence of cyanogenic glycosides and anthraquinones, thus the extracts may not have toxic effects. Identification of bioactive compounds in through GC-MS analysis showed the presence of compounds that are known as antimicrobials and also effective in the treatment of selected...
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