Posted by admin on Aug 31, 2017 in |
Introduction: Irbesartan is chemically 2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl) phenyl] phenyl} methyl) -1,3-diazaspiro [4.4] non-1-en-4-one. Irbesartan is an Angiotensin II receptor antagonist effective in the treatment of Hypertension. It is also effective in the treatment of High blood pressure. It is also effective when used alone or in combination with other drugs. Aims and Objectives: Objective of the present study is to develop a simple, sensitive, accurate, precise and rapid first order derivative spectrophotometric method for the estimation of irbesartan in pure form. Results: For the estimation of irbesartan, solvent system employed was 50% v/v aqueous ethanol and wavelength of detection (λdet) was 237 nm. The linearity was obtained in the range 8 -18 µg/ml, with a regression coefficient, R2 = 1. Discussion: Obtained results showed that there is minimum intraday and inter day variation. The developed method was validated and recovery studies were also carried out. Sample recovery using the above method was in good agreement with their respective labeled claims, thus suggesting the validity of the method and non-interference of formulation...
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Posted by admin on Aug 31, 2017 in |
Ballota nigra (Lamiaceae) has been widely used as traditional medicine in many countries for the treatment of neuro-sedative, antidepressant, antioxidant, antibacterial, insecticidal, anticholinesterase and antifeedant effects. The main objective of this study is to evaluate the antibacterial activity of leaf extracts of Ballota nigra Linn. against five bacterial pathogens. The leaves were extracted in five different organic solvents and their potential were tested against three Gram negative bacteria (Escherichia coli, Salmonella typhi and Salmonella paratyphi) and two Gram-positive bacteria (Micrococcus luteus and Bacillus subtilis) using Agar well diffusion method. The results indicate that most of the extracts showed prominent activity against all the bacterial strains. The methanol extract was most effective with zone of inhibition ranging from 12.20 ± 0.19 to 22.20 ± 0.19 mm for all the tested strains, while chloroform and ethyl acetate shows moderate activity. It clearly depicts that the methanol extract exhibit significant antibacterial activity due to the presence of phyto-constituents. This work can be further explored to in vitro studies for isolation and identifying...
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Posted by admin on Aug 31, 2017 in |
Purpose: Several medications are currently available for trying smoking cessation, such as nicotine replacement therapy or antidepressants. This study investigates potential effect of Meclezine-B6 combination; and B6 tablets administrated orally for possibility of reducing number of cigarettes smoked per day during 10 days. Methods: Using placebo control study. In which adult smokers’ volunteers were assigned to one of study groups; control (N=20) or meclizine-B6 (N=50) and B6 group (N=50). All volunteers take their medications as single daily dose at night and the start to report number of cigarettes smoked daily from day 1 to day 10 with reporting the side effects appeared during the study. Results: The results showed there was significant declining in number of cigarettes daily smoked as compared with day 1 of study especially in B6 group. In This group, also higher percentage of volunteers showed significant smoking declining as compared to meclizine-b6 and control group. And most common side effects reported were drowsiness and headache especially in meclizine-B6 group. The potential role of B6 in...
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Posted by admin on Aug 31, 2017 in |
The aim of current investigation was to formulate and evaluate an oral time controlled drug delivery system to achieve timed release of Candesartan cilexetil for the treatment of cardiovascular complications. Blood pressure rises early in the morning which can leads to hypertension and congestive cardiac failure. Attempt has been made to develop a drug delivery which releases the drug based on changes in circadian rhythm. Time dependent pulsatile drug delivery consists of a core tablets containing Candesartan cilexetil with different excipients surrounded by coating materials. Coating materials consist of combinations of hydrophilic polymer as HPMC and hydrophobic polymer as ethyl cellulose in various combinations. Formulated tablets were evaluated for its micromeritics as well as post compression characteristics such as weight variation, hardness, friability, drug content uniformity and in vitro drug dissolution. The drug-excipients study was carried out by using FTIR. In vitro drug release studies were performed using pH 6.5 phosphate buffers for 8 hrs. Optimized formulation F10 was selected and tested for its accelerated stability which was found...
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Posted by admin on Aug 31, 2017 in |
Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and help to overcome non-communicable diseases like diabetes mellitus, obesity, hyperlipidemia, cardio-vascular diseases, etc. It is rich in micronutrients, especially vitamin B and minerals, Phytochemicals and dietary fiber. The phenolic compounds in minor millets also helps in the prevention of chronic diseases like Cancer. Minor millets like Paspalum scrobiculatum L., Panicum sumatrense Rothex Roem. and Schult, Eichinochola frumentacea Link and setaria italic (L.) P. Beauv. were chosen for the study. The bilaterally ovariectomized rat is an animal model for the studies related to menopause. The powdered minor millets were mixed with rat pellet and fed to the ovariectomised rats. After three months of the study, the blood...
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