Posted by admin on Aug 31, 2017 in |
Marine algae are one of the largest sources for biogenic compounds. They produce a wide variety of chemically active metabolites. They are found to possess significant antioxidant, and phytochemical activities. Macroalgae provides a great variety of metabolites and natural bioactive compounds with antimicrobial activity, such as polysaccharides, polyunsaturated fatty acids, phlorotannins and other phenolic compounds, and carotenoids. Several species of brown algae have been investigated for their bioactive natural products. The aim of the present study was to investigate the antioxidant, antibacterial activity and GC-MS analysis of active compounds present in the methanol extract of the brown algae, Padina tetrastromatica. For antioxidant activity, DPPH radical assay, ABTS radical cation scavenging assay, phosphomolybdenum reduction assay and Fe3+ reducing power assay were carried out. The maximum DPPH radical scavenging activity was 54.78%. The extract also exhibited significant antibacterial activity against the clinical pathogens, Vibrio cholera, Shigella flexneri and Pseudomonas aeruginosa. The phytochemical analysis showed the presence of alkaloids, terpenoids, steroids, flavonoids and phenolic compounds. GC-MS analysis revealed the presence of fatty...
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Posted by admin on Aug 31, 2017 in |
The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent cells and calcitonin gene related peptide are neuro-peptides secreted by sensory neurons. In present study the immune histochemical localization for connexin 36 gap junctions and CGRP was done in the trigeminal ganglion of male Wistar rats. The result showed connexin 36 was present between the satellite glial cells, between satellite glial cell and neuron and in the schwann cells. CGRP was localized densely in the cytoplasm of small neurons. The excited neuron can influence the surrounding satellite glial cells and neurons through gap junctions and by paracrine actions altering its environment leading to pathological role in inducing painful conditions like...
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Posted by admin on Aug 31, 2017 in |
Inflammation is an inflammatory process where histamine, kinin, prostaglandins and slow release substances are produced in the tissue of the body to cause irritation or injury. It consist three phases, dilation and increased permeability of small blood vessels resulting in oedema and swelling, emigration of leucocytes from venules, capillaries and cellular infiltration, proliferation of fibroblasts and synthesis of new connective tissue to repair the injury. Present study deals anti-inflammatory activity of extracts of Woodfordia fruticosa stems bark in animal models by mercury displacement volume method. Paw oedema was produced by injecting in a 0.1ml volume of formalin into the sub plantar tissue of the rat hind paw foot. The extracts of petroleum ether, chloroform, ethanol and aqueous extracts were administered orally to the albino rats in their respective groups. Test drugs were given at a dose of 200mg/kg according to their body weight. The results of aqueous extract of barks exhibited statistically significant (**P<0.01 and *P<0.05) anti-inflammatory activity in albino rats. Maximum percentage inhibition had been found in aqueous...
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Posted by admin on Aug 31, 2017 in |
The traditional health care system has been significantly used from ancient time. The rural people of Purba Medinipur, West Bengal still continue to depend on indigenous plants to cure their different types of primary health treatment. The present study explore 79 plant species belong to 41 families are systematically used in traditional health care system. Information was collected by the structures questionnaire, consultation and interviews with rural people, knowledgeable persons and women folk. The plants are principally used for the treatment of digestive disorder (24.4 %), respiratory trouble (25.64 %), dysentery (16.66 %), bleeding (12.8 %), snake and insect bite (11.53 %), skin infection (12.8 %) and sugar control (10.25 %). These wild medicinal plants are declining in number due to demolition and unscientific collection of plants. There is a requisite need to conserve the indigenous medicinal plants. This document will help to prepare a database of valuable indigenous plants and their issues for...
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Posted by admin on Aug 31, 2017 in |
A drug dosage form is very important in delivering the drug in proper dose in most appropriate form. The capsule shell is an excellent barrier to air, and it also has some other advantages such as being easy to swallow and tasteless, flexibility of formulation etc. The use of the hard gelatin capsule dosage form may perhaps be an alternative to overcome the problem, which the hygroscopicity of the extracts may pose. Present study was envisaged to develop a polyherbal formulation as capsule. The results obtained by the thermo analytical techniques showed no chemical incompatibility between capsule shell and herbal extract. The results were further confirmed by IR spectroscopy. The herbal capsule was stored at different temperatures viz., 25 0C, 40 0C and 50 0C for shelf life evaluation. The percentage alkaloid content for day zero was taken as 100% and accordingly, the percentages were calculated for all the other days. The organoleptic properties of the herbal capsule remain unchanged at tested temperatures throughout the stability study. Likewise, pH...
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