Posted by admin on Sep 30, 2017 in |
The ultimate aim of this research work is to develop a cisplatin loaded chitosan nanoparticle system (CCNP) to facilitate the release of cisplatin in a more sustained manner to improve therapeutic efficacy via the reduction of its toxicity. As a step-in formulation studies the work has been limited to studying the various physical characters of CCNP using a zeta nanosizer. The chitosan polymer was selected in this study because of the high poly-cationic, biodegradable and biocompatible characters. The drug of choice is cisplatin, a well-known anticancer drug, used in the treatment of various cancer types. CCNP was prepared using the ionic gelation technique and characterized using the Malvern zetasizer nano zs instrument, UK to find out the polydispersity index (pdi), zeta potential and particle size determination. The ideal nanoparticles were exhibiting + 45.4 mV, 595.3 z.dnm and 0.6 pdi. The study concluded that CCNP can be formulated at an optimum concentration of 40 µg/ml of cisplatin entrapped in 2 mg/ml of aqueous solution of chitosan in the presence of...
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Posted by admin on Sep 30, 2017 in |
Lutein is a lipid soluble, oxygenated derivative of hydrocarbon carotenoid, from xanthophyll family which is naturally present in egg yolk, vegetables and several dark green plants. In human eyes, Lutein and zeaxanthin are the only two carotenoids present in the macula region to filter the harmful ultra violet rays. They protect the eye from oxidative damage associated with diseases such as cancer, cataracts and age related macular degeneration (AMD). Treating AMD is expensive and also prone to after effects of the treatment. Hence a natural low cost alternate has been investigated in this research article. Eichhornia crassippes, an aquatic perennial herb weed belongs to pontederiaceae family a dark green-leaf was taken as source for the lutein extraction as it has carotenoids in abundance. Lutein was identified, isolated and purified from crude leaf extract and was analysed by GC-MS, TLC and HPLC using hexane as mobile phase. To improve the bioavailability and stability of lutein, it was micro-emulsified with coconut oil using high energy sonication method. The oil in water...
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Posted by admin on Sep 30, 2017 in |
In this research work, a well established method was used to synthesize of stannane of 2, 4-hexadienoic acid and its characterization was carried using ultraviolet (UV)-visible and 1H NMR (nuclear magnetic resonance). Our research aimed at developing a potent multi-target drug which could act as antibacterial agent and also peroxisome proliferator-activated receptor gamma (PPAR γ) agonists that is having the potential to activate the PPAR γ. In vitro antibacterial study was carried out against, Staphylococcus aureus (gram positive) and Escherichia coli 1610 (gram negative) using ‘well diffusion method’. It was followed by in silico docking studies, using computational software iGemDock v2.1 tool and its effect on glycemic and lipid parameter was also studied. Pharmacokinetic properties were studied using pkCSM software developed by the University of Cambridge. Drug likeness study and all the specifications were tested with the help of Molinspiration Molecule Viewer software available online. It was observed that the stannane of 2, 4-hexadienoic acid inhibited the bacterial growth of Staphylococcus aureus (gram positive) and Escherichia coli 1610 (gram...
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Posted by admin on Sep 30, 2017 in |
In present study total 2352 samples were collected out of that 21.04% were positive for Typhoid fever while 78.95% were negative. The sex wise distribution results showed male are more effected (12.71%) as compare to female (8.33%). However, the age wise distribution showed that 10.45% in 6-10 years, 6.54% in 3-6 years and 4.03% in 1-3 years. Moreover, the Typhoid fever cases were significantly high (8.41%) in Pashtoon followed by (6.93%) in Baloch, (4.16%) in Punjabi and (1.53%) in Hazara. The 11.60 % Typhoid fever was observed in the patients with low socioeconomic status, 6.67% in middle socioeconomic status and 2.76% in the patients belonged to high socioeconomic status. The electrolytes imbalance results revealed that Sodium was low in 9.82% patients and Potassium was low in 7.21% patients while the calcium was low in 4.01% Typhoid patients. The significant Typhoid fever cases were reported in July (2.97%) August (3.13%) and September (3.92%) as compared to other months of the...
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Posted by admin on Sep 30, 2017 in |
Herb is an indispensable food ingredient for the tribal people of Arunachal Pradesh. They practices innumerable traditional food recipe to maintain good health. Spilenthes oleracea L. is one of such medicinal food plant used by tribal people of Arunachal Pradesh. The study was carried out to find out the phytoconstituents of S. oleracea shoot. Ethanolic extract of the sample was subjected to GC-MS to know the Phytoconstituents of this herb and correlate the phytoconstituents and health claim thereof if any. This study reports the presence of 48 phytocompounds and a total of 10 compounds identified from this sample have been reported to show painkiller effect that complements the traditional knowledge on this herb among the tribal people of the study site and scientific evidence. Sesquiterpene, Polyenoic fatty acid, Steroidal, Palmitic acid ethyl ester and Hydrocarbon are the major group of compound found from the sample. Present work advances S. oleracea as a medicinal food...
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