Posted by admin on Sep 30, 2017 in |
Introduction: Obesity is a morbid condition characterized by abnormal or excess deposition of body fat to an extent that it adversely affects health. The basic etiology behind obesity is the disparity between the energy intake and energy expenditure. Lifestyle modifications and drug treatment is the mainstay of treatment. Unfortunately the benefits are for short term that might be because of cessation of drugs use or side effects which ultimately leads to rebound weight gain. Methods: Experiment was conducted on 42 adult healthy female wistar rats weighing around 150-200g, divided into 7 groups with 6 rats in each group. Group 1 given normal chow while others were given High Fat Diet (HFD). From 5th week till the end of 8th week group 3 to 7 were given respective drugs (extracts of Gymnema sylvestre and Acorus calamus). Obesity parameters (body weight, BMI, locomotor activity) were recorded on day 0, at the end of 8th week and at the end of 8th week. Internal organs (kidney, liver, spleen and heart) and fat...
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Posted by admin on Sep 30, 2017 in |
Biologically active compounds identified as flavonoids, glycosides, alkaloids, saponins, terpenoids and polyphenolics from plant extracts possess health promoting properties. The use of natural antioxidants in the treatment of various skin diseases has gained utmost importance in recent years. Therefore, present study was designed and conducted with the aim to evaluate the anti-inflammatory activity of cream formulation containing fruit extracts of Musa acuminata, Psidium guajava and Pyrus communis using in vitro model. Fruit of M. acuminata, P. guajava and P. communis were extracted by cold percolation, comprising of ethanol, methanol and distilled water. The cream formulation and the reference drug (Diclofenac sodium) of varying concentrations were incubated with fresh egg albumin under specified experimental conditions and subjected to determination of absorbance and viscosity to assess the in vitro anti-inflammatory activity. Linear regression analysis was used to calculate IC50 value. The results revealed that cream formulation and diclofenac sodium inhibited protein denaturation in a dose-dependent manner. The IC50 value of cream formulation 1254.13±16.91µg/ml and diclofenac sodium was recorded as 845.82±16.94µg/ml at correlation coefficient value...
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Posted by admin on Sep 30, 2017 in |
Background: Hypertension (HTN) is an important public health problem in both economically developed and developing nations. World Health Organization (WHO) data indicate that by 2025 the global burden of hypertension will increase by 60% to be 1.56 billion individuals worldwide and higher in the developed nations. Hence the present study is aimed to assess the heart healthy practices among patients with Hypertension. Assess the risk regarding complications among patients with Hypertension. Associate the heart healthy practices and risk for complications with selected demographic variables. Materials and Methods: The descriptive design was used in this study. 50 samples were selected using Purposive sampling technique. Heart healthy practices were assessed by using the devised 5-point Likert scale. Risks for complications were assessed by Modified Q- intervention scale. The collected data were analyzed statistically. Results: 48 (96%) of the patients demonstrated better heart healthy practices. Most of the participants were moderately risk 29 (58%), and few were at high risk 14 (28%) to develop complications regarding hypertension. A negative correlation was found...
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Posted by admin on Sep 30, 2017 in |
The present research was aimed to formulate erosion based matrix tablets of ketoprofen micro-sponges for spatial-colon targeting. For the optimization, the effects of independent variables like solvent volume and concentration of chitosan were studied on the mean particle size, percent entrapment efficiency (% EE) and in vitro drug release. Scanning Electron Microscopy (SEM) image of the micro-sponge formulation revealed that the surface of the micro-sponge was nearly spherical and porous. Optimized micro-sponge formulation was further formulated into erosion based matrix tablet and evaluated for quality control parameters. In vitro release studies revealed that both the micro-sponge formulation and micro-sponge matrix tablet (MST) had restricted the drug release of ketoprofen in gastric pH followed by gradual release up to 12 hr. The release kinetics data, after fitting into various models revealed that both formulations were best fitted to zero order, indicating controlled release property. The pharmacokinetic evaluation of colon targeted MST in rats revealed the presence of drug in plasma after lag time of 4 hr, tmax of 4 ±...
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Posted by admin on Sep 30, 2017 in |
Background: Influenza and influenza like illness (ILI) is a common respiratory illness among HIV patients. ILI is caused by various respiratory viruses and bacteria other than influenza virus. The symptoms of ILI recover within a few days, but in HIV patients ILI with opportunistic coinfections may lead to serious complications and hospitalization. Objective: To determine the incidence of human rhinovirus (HRV) coinfection with Staphylococcus aureus among HIV patients suffering from flu like illness. Materials and Methods: In this study 92 throat swab samples of flu suspected HIV patients were collected from Department of Immunology, SGPGIMS, Lucknow and ART Centre, RMLIMS, Lucknow, during 2014 – 2015. Samples were cultured on mannitol salt agar (MSA) plates, Staphylococcus aureus were confirmed by the biochemical characterization. The confirmation of HRV was done by RT-PCR. HeLa cell lines were used for isolation of human rhinovirus. Results: The prevalence of HRV was found 17 (18.5%), while S. aureus were isolated from 40 (43.5%) samples. Coinfection of S. aureus was found in 11 HRV positive samples...
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