Posted by admin on Jun 30, 2024 in |
Ethnogynaecology is a young field of study that emphasize how indigenous people and local healers manage gynecological conditions in females. The goal of the current study was to record in-depth information about Ethnogynaecology in a previously unexplored region of Haryana. In the year 2022, a floristic and ethnomedicinal survey was conducted in Haryana, India in rural areas of Gurugram district. The present study identified forty plant species with twenty-seven families for treatment of various gynecological disorders. The most frequently used plant parts for herbal preparations were roots followed by leaves, fruit, bark, seed, whole plant, stem, buds, and bulb. The ethno-gynecological significance of medicinal plants in India provides a fertile ground for further scientific investigation to assess their potential, isolate bioactive compounds, and subsequently develop medications for the widespread gynecological health problems experienced by women...
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Posted by admin on Jun 30, 2024 in |
The increased use of antibiotics and the rise of antibiotic resistance among microorganisms pose significant public health concerns. While several herbal drugs have been validated for their antimicrobial activity, identification of additional antimicrobial agents is necessary. The Unani system of medicine comprises numerous herbs and formulations used for treating various infections. Arq e Ajeeb (AA) is one such formulation, historically utilized during epidemics to address conditions such as cholera (Haiza), tuberculosis (Sil), plague(Taoon), and seasonal fevers. Additionally, AA has been used as an anti-inflammatory and analgesic. This study aimed to evaluate the in-vitro antimicrobial activity of AA on four different bacteria, considering antibacterial properties demonstrated by its ingredients. The antibacterial activity of the test sample was evaluated using the minimum inhibitory concentration (MIC) method. Bacterial strains (P. aeruginosa, E. hirae, E. coli, S. mutans) were inoculated in 100μl sterile MHB broth. A test sample underwent double dilutions ranging from 100 to 0.048828mg. Ciprofloxacin (0.1%) served as the standard antibiotic. The plates were incubated at 32.5 ± 2.5°C for 24...
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Posted by admin on Jun 30, 2024 in |
This research investigates the anti-inflammatory potential of Azadirachta indica-loaded microsponges gel, presenting a novel therapeutic approach. The microsponges gel, formulated with Azadirachta indica, aim to enhance drug delivery efficiency for improved anti-inflammatory effects. The microsponges gel is formulated using Carbopol 934P (1% w/v) to optimized encapsulated microsponge. Prepared formulation was evaluated for pH, spreadability, viscosity, and ex-vivo drug deposition study. Characterization studies, in-vitro release assessments, and anti-inflammatory assays contribute to a comprehensive evaluation of the formulated microsponge gel. Preliminary results demonstrate successful formulation of Azadirachta indica-loaded microsponge gel. Characterization studies confirm the structure and composition. In-vitro release studies reveal sustained drug release, and initial anti-inflammatory assays indicate promising activity. This study underscores the potential of Azadirachta indica-loaded microsponge gel as a promising anti-inflammatory therapeutic strategy. The formulation’s sustained release profile and demonstrated efficacy in anti-inflammatory assays pave the way for further investigation and potential clinical...
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Posted by admin on Jun 30, 2024 in |
A simple, precise yet novel UV spectrophotometric method has been developed for the simultaneous estimation of luliconazole and eugenol. Two methods, namely the simultaneous equation method and the absorbance ratio method were tried for simultaneous analysis. Since the simultaneous equation method gave the best recovery; the simultaneous method was developed for the estimation of both drugs. The wavelength of interest is the wavelength maxima of both drugs; λmax of luliconazole 296 nm and λmax of eugenol 282 nm. The correlation coefficient value (r2) was found to be 0.99 for linearity studies both in methanol and phosphate buffer. Validation studies of the developed method were conducted as per ICH guidelines. The method was precise since the percent relative standard deviation was less than 2 and accurate since the percent recovery was between 99.42% and 105.16%. The developed method can be further used for simultaneous analysis of the drugs in bulk and formulation by UV spectroscopy. The development of a suitable analytical method for quantitative estimation is essential for assay and...
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Posted by admin on Jun 30, 2024 in |
Fungal infections represent a significant global challenge within the realm of dermatology. The prevalence of fungal infections is notably high, affecting approximately 40 million individuals in developing and underdeveloped countries. Considering this, our study proposes a novel approach: transdermal drug delivery utilizing herbal formulations to enhance efficacy & minimize side effects in the treatment of fungal infections. Seven Ayurveda plants extracts were selected & formulated in a 1:1 ratio. These herbal formulations were incorporated into dermal patches composed of HPMC& PEG. Subsequently, the herbal transdermal patch was subjected to characterization like UV spectrometry, folding endurance, thickness measurement, & surface pH determination. The antifungal property of these patches was evaluated against Candida albicans by determining MIC and Agar Well method. The prepared patches exhibited distinctive UV-visible spectra within the 200-800 nm range for the HPMC-based, displayed a thickness of 0.063 ± 0.01, a weight of 206 ± 5.1 mg, and a surface pH of 5.7. The transdermal drug delivery system demonstrated potent fungal inhibition at a concentration of 2.5 mg/ml,...
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