Posted by admin on Jan 31, 2024 in |
Antidyslipidemic activity of extract of Eugenia jambolana (EJ, Jamun fruit) in adult Charles Foster rats of both sexes was studied and compared with that of Atorvastatin (Atorva). 4 groups were made [Gp 1- Control group (no drug), only high fat diet (HFD); Gp 2- HFD +EJ (evaluation of role of EJ in the prevention of dyslipidemia); Gps 3 & 4-only HFD]. This was the phase of disease production, lasting for 7 weeks, in which we also evaluated the preventive role of EJ. Thereafter, therapy phase started, which lasted for 90 days [Gp 1-Control group (no drug). Only HFD; Gp 3- HFD+ Atorva; Gp 4- HFD+EJ]. Parameters tested were TC (total cholesterol), TG (triglycerides), LDL (low density lipoproteins) and HDL (high density lipoproteins). During the prevention/ disease production phase, EJ brought an improvement in TC level as compared to control group, which was statistically not significant; but improvements in TG, LDL & HDL levels were significant. Moreover, in the therapy phase, EJ brought significant improvement in all the parameters. It...
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Posted by admin on Jan 31, 2024 in |
In this study, the preventive and protective potentials of Murray koenigii (MK) leaves and Momordica charantia (MC) fruit extracts against experimentally induced peptic ulcers in Wistar rats were evaluated. Rats were divided into six experimental groups – normal (saline), control (ulcers), pretreatment with MC extract (fresh fruit juice, 500ml/kg), MK extract (400mg/kg)or both, and pretreatment with standard drug ranitidine (RTD). Parameters assessed in the study were -ulcer score, ulcer index, free acidity, total acidity, percentage of ulcer inhibition, pH of gastric juice, gastric volume, C-reactive protein, macroscopic evaluation of the stomach, and histopathological studies. The results of the pharmacological studies on the co-administration of MK extract and MC juice showed a significant decrease in ulcer score, ulcer index, gastric volume, free acidity, total acidity, and CRP value when compared to positive control. The pH and percentage of ulcer protection were significantly increased in the co-administration extracts treatment group comparably with the standard ranitidine group. Hence, the study revealed that pre-treatment with the combined administration of Murraya koenigii leaves and...
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Posted by admin on Jan 31, 2024 in |
Objective: The main purpose of this current work is to optimize the formulation and in vitro evaluation of gabapentin niosomes. Methods: Niosomes are formulated by utilizing the thin film method. Gabapentin niosomes are prepared with cholesterol and span 80. Pre-formulation and post-formulation studies were carried out for optimized gabapentin niosomes. Such as FTIR, DSC, Zeta, Particle size, TEM, SEM, and in-vitro drug release studies. Report: Gabapentin medication pre-formulation experiments were carried out. The ultraviolet spectroscopic maximum of gabapentin was found to be 206nm. Within the concentration range of 2-10 g/ml of drug in phosphate buffer 7.4 solutions; gabapentin follows Beers law with a slope of 0.1086 x and an R2 value of 0.9985. The particle size was determined to be round and spherical in the improved formulation F7. The particle sizes are in the 50-120mm range. Particle’s external morphology/outer surface morphology were determined. Conclusion: The goal of this study was to optimize the formulation and in-vitro evaluation of gabapentin niosomes for epilepsy treatment. As a result, the current research...
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Posted by admin on Jan 31, 2024 in |
To estimate the presence of para-phenylenediamine in various commercial hair colors, a straightforward, speedy, precise investigation used High-Performance Liquid Chromatography to find PPD in henna and determine its presence. In order to do the chromatography, stationary phase Phenomenox C18 100 mm x 4.6 mm, 5µm column system was used for UV detection with a242 nm wavelength. The mobile phase Methanol with water (HPLC grade) (70:30) was used as the mobile phase for the technique, which was created and validated for the detection of PPD in samples of commercial hair color. With a run time of 7 minutes, a retention time of 2.088 seconds, and a flow rate of 0.55 ml/min, the method was validated over a broad linear range of 5-28 g/ml. The PPD content of hair colors may not exceed 6%. The procedures were approved in line with ICH...
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Posted by admin on Jan 31, 2024 in |
The ideal of the exploration is to formulate hydrogel containing nanosponges of Triamcinolone acetonide for the treatment of Psoriasis. Psoriasis is presently treated with a numerous of topical and systemic remedies. Numerous of these treatments, still, are costly and involve adverse effects, similar as immunosuppression. As a result, there is a need to develop curatives that are effective, have less adverse effects, and are less costly. With the use of solvent emulsion diffusion process triamcinolone acetonide nanosponges were formulated, in which Eudragit L-100 was used as polymer, polyvinyl alcohol was used as an emulsifying agent, and an organic solvent mixture of Dichloromethane was used to make nanosponges. For the preparation of optimized batches of Hydrogel containing nanosponges various gelling agents were used such as Carbopol 934, HPMC K4, Sodium alginate and Acacia with same concentration. Therefore, with the help of different analytical tests i.e., SEM, FT-IR, Zeta potential etc. It was confirmed that by using the nanosponges formulation the biopharmaceutical characteristics of triamcinolone acetonide increased which is a BCS...
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