Posted by admin on Oct 31, 2017 in |
The aim of the present study was to investigate the potential of a micro-emulgel formulation for topical delivery of Terbinafine. Terbinafine showed highest solubility in propylene glycol among the available oil phase. Tween 80 and polyethylene glycol 400 were used as surfactant and co-surfactant respectively. Using pseudo-ternary phase diagram 1:2 ratio of surfactant: co-surfactant was selected. Using Central Composite Design thirteen formulations with varying ranges of Smix and oil phase were prepared. Final formulation was selected on the basis of transmittance. From optimization plot it was concluded that 27.93% of Smix and 6.51% of oil phase gave maximum transmittance. Then, optimized formulation was used to prepare final microemulgel of terbinafine. Thirteen gel formulation from varying concentration of carbopol 934 and hydroxypropylmethyl cellulose was prepared and evaluated for extrudability, spread ability, drug content, in-vitro drug release, rheological study and in-vitro antifungal activity against Teniapedis. Formulations with suitable consistencies were selected and optimization was done on the basis of drug release and ex-vivo permeation study in goat skin. Formulation with 0.45gm...
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Posted by admin on Oct 31, 2017 in |
Lipid metabolism in animals has recently gained growing interest among researchers. Among organic compounds, it is only protein and nucleic acids that for a long time have remained in primary focus of research, though lipids are now known to be essential for the origin of life and development of organic forms. Metabolic processes are very active in the bodies of high-producing cows. Large amounts of energy and nutrients are utilized to synthesize milk; all body systems function intensely. Consequently, there are increased demands for adequate supply of energy and all nutrients including lipids. Insufficient or excessive intake of the latter leads to disruption of metabolism, lower productivity, and deterioration of animal health. At present, there is some controversy in the Russian and foreign literature in regard to on the optimal fat content in the dry matter of the rations of lactating cows, especially high-producing ones. Researchers recommend rather wide ranges of fat concentrations in the diets. The issue that remains insufficiently explored is the effect of various fat levels...
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Posted by admin on Oct 31, 2017 in |
Pomegranate fruits are a very rich source of antioxidants, Vitamin B5 (pantothenic acid), potassium, flavonoids and have numerous health benefits. It may help decrease the risk of having a heart disease, heart attacks, and strokes. These characteristics of pomegranate have great impact on the quality of wines. So there might be a scope for large scale manufacturing of the pomegranate wine as it has many health benefits than grape wine Thus, the present study is aimed at investigating the fermentation parameters of pomegranate wine. Fermentation of pomegranate was carried out by a yeast strain. The present study provides information on the parameters like inoculum size, pH, incubation temperature, substrate concentration and incubation period involved during wine production. These parameters are the part and parcel of wine production, without the knowledge of these parameters one cannot make a tasty and good quality wine. We see a significant variation between residual sugar % (w/v) & alcohol % by applying ANOVA for all parameters. Analysis reveals that best wine from pomegranate can...
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Posted by admin on Oct 31, 2017 in |
In the present study, the inhibitory effect of crude ethanolic extracts from four plants viz. Bauhinia racemosa Lamk (stem bark and roots), Holoptelea integrifolia (Roxb.) Planch. (roots), Kirganelia reticulata (Poir) Baill. (Stem bark) and Phyllanthus maderaspatensis Linn. (whole plant) were undertaken against some test bacteria and test fungi using Disc Diffusion Method. The screening data indicated that the antibacterial activity of the ethanolic extracts of B. racemosa (stem bark and root) inhibited the growth of S. aureus and P. vulgaris and H. integrifolia (roots) was found active against S. paratyphi B. The other two plants were totally inactive in this respect. A comparative study of the fungicidal activity of the four plant species indicated that although all of them exhibited activity against the select test fungi out of which the activity against A. flavus was most significant. Roots of B. racemosa were significantly active against A. niger, F. moniliforme and stem bark was active against R. bataticola. These could be attributed to the presence of racemosol and its derivatives...
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Posted by admin on Oct 31, 2017 in |
Inflammation plays fundamental role in hepatocellular carcinoma (HCC) initiation, progression and metastasis. The over expression of pro-inflammatory factors like Tumor necrosis factor-α (TNF-α), selectin, (IL)-6, nuclear factor-κB, TGF-β can alter the hepatic microvasculature. Natural products such as polyphenols, alkaloids, flavonoids, and flavonols have the ability to interface microenvironment of carcinogenic tissue. In the current study we have established human protein interaction network (HPIN) composed of 21 queries (inflammatory proteins related to HCC) and more than 493 neighboring proteins. This interaction provides some potent receptors for docking of plant based immunosuppressant with pro-inflammatory proteins. We have selected eighteen herbal compounds and docked with receptors (ALDH1, TGFBR1, and P2RY2) using Schrodinger software. The study suggests an integrated approach to normalize the immunological dysregulation for HCC treatment through silibinin, leonurine and...
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