Posted by admin on Oct 31, 2017 in |
Liver manage different critical metabolic functions. The point of this review is to think about hepatoprotective movement of lycopene and non lycopene containing part of tomato concentrate to investigate the likelihood that a few constituents other than lycopene may be in charge of hepatoprotective action. Writing uncovered that plant containing Carotenoids, Lycopene, Carotene, Xanthophylls, Xanthophylls Ester mixes were in charge of hepatoprotective action and they chose plant additionally having these constituent so it was conjectured that it might likewise have the capacity to ensure the liver. Keeping this view exhibit study is meant to arrange the work for the impact of hepatoprotective action of Lycopersicon esculentum. Paracetamol-initiated liver rot was repressed essentially by methanolic-I extricate (Non-lycopene fractionate) of Lycopersicon esculentum. The outcomes reasoned that the Methanolic-I (Non-lycopene division) was more compelling than the Methanolic-II (Non-lycopene part) extricate. The CCl4-III (Lycopene division) was observed to be not powerful in the treatment of the hepatotoxicity. In this manner it can be derived from this examination that Lycopersicon esculentum showed hepatoprotective action...
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Posted by admin on Oct 31, 2017 in |
The main aim of this study was to prepare solid dispersion of Candesartan cilexetil so as to improve its solubility and dissolution characteristics in order to enhance its oral bioavailability. Solid dispersion was formed by fusion method. 9 formulations (F1-F9) were prepared using different carriers i.e. Sorbitol, Polyethylene Glycol (PEG 6000) and Poloxamer 407 at different ratios of 1:1, 1:3, 1:5 each. Out of 9 formulations, F3, F5 and F9 formulation compositions were selected on the basis of solubility, % yield, drug content, in-vitro dissolution studies. F3, F5 and F9 formulations were further formulated in 3 batches (A, B, C) into conventional dosage forms (tablet) with ingredients such as lactose, SSG, MCC, magnesium sulphate, and talc. On the basis of physical and chemical evaluation (Disintegration and dissolution studies), F9 was considered as the optimized formulation. The Optimized formulation, F9 i.e. Batch C was further compared with the Marketed formulation (Atacand, 4 mg) and stability studies were performed according to ICH guidelines. The optimized formulation of solid dispersion of Candesartan...
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Posted by admin on Oct 31, 2017 in |
Multiple causes of liver diseases that will affect the health related quality of life and are dispersed globally. It is difficult to diagnose the different stages of liver disease. Scores like Child Pugh Score(CPS), Model For End Stage Liver Disease(MELD), Monoethylglycinexylidine(MEGX), Von willibrand factor (vWF) etc are used to detect the progression of liver disease like hepatitis, cirrhosis, fibrosis etc. Child Pugh Score is important and traditional component for evaluation of liver disease. It is easy to perform at bed site. MELD is for predicting short term mortality and is more objective but not superior to CPS due to some reasons. These scores contain subjective as well as objective parameters for better prediction of liver related disease. MEGX and von villibrand factor are better simplest markers for the prognosis of liver disease. MEGX is competent to various scores and useful marker for impaired metabolic activity and blood flow in cirrhotic patient. vWF is new non invasive method for survival rate of patient with compensated and decompensated liver disease. By...
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Posted by admin on Oct 31, 2017 in |
Hepatic cancer is one of the most causes for cancer death in the world. The aim of this work was to compare and survey the cytotoxic activity of a group of differently classed flavonoids and three plant extracts known for their high antioxidant activities against Hep-G2 human cancer cell line. Also to isolate some flavonoids from the plant extracts using easier, modified methods of higher yield and lower time of extraction than conventional ones. Different flavonoidal classes were tested against Hep-G2 human cancer cell line using SBR assay. Doxorubicin was used as a positive control. Dihydroquercetin was found to be more potent even than Doxorubicin. It showed the higher activity with IC50 = 4.43±0.08 μg/ ml followed by quercetin and rutin with IC50 = 7.88±0.89 and 11.2 ±0.97μg/ ml respectively. Among the tested extracts, rosemary alcoholic extract was the potent followed by green tea alcoholic extract and orange peel alcoholic extract was the less potent. Their IC50 values ranged from 11.5±1.02μg/ml to 48.2 ±1.8μg/ ml. Diosmin and catechins showed...
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Posted by admin on Oct 31, 2017 in |
Over time, ethnomedicinal plants have been praised hugely for the presence of diverse pharmacologically active phytochemicals and have been used traditionally in primary medication to cure various human diseases or disorders. In the present study, different phytochemical constituents were analysed and free radical scavenging activities of Dregea volubilis stem bark (DvSB) extracts were assayed. Different in vitro scavenging tests such as DPPH· scavenging assay, O2·– scavenging assay, OH· scavenging assay and H2O2 scavenging assay were employed to estimate the free radical scavenging potentiality. Results revealed that methanolic extract had superior scavenging activity over the hot water extract. Qualitative analysis of phytochemicals showed the presence of reducing sugars, phenolic compounds, flavonoids, resins, glycosides, cardiac glycosides and steroids; and quantitative phytochemical analysis for polyphenols, flavonoids, flavonols, proanthocyanidins and alkaloids were made by standard procedures. Hence the study reveals that DvSB has significant scavenging properties, thus validating the ethnic usage for treating stress-related complications and restoration of good...
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