Posted by admin on Jul 31, 2017 in |
Synthesis of new organometallic Schiff bases complexes with general formula [ML)xH2O] [where M = Mn(II), Ni(II), Cu(II) Pd(II) and Pt(II), L=2,2′-{(1R,1′S)-1,1’Ferrocen-2,4-dien-1-yl-2,2′-diyl bis [(Z)methyl-ylidenenitrilo]}bis(3-iodophenol)] have been prepared and characterized by elemental analysis, magnetic susceptibility, Conductivity IR, UV-Visible, Mass spectra and TGA/DTA. Organometallic Schiff base is tetradentate and co-ordination through nitrogen of azomethine (>C=N-) and oxygen of Hydroxyl group. The complexes have octahedral geometry with six coordination number. Electronic spectra of the complexes were recorded and its parameters like Nephelauxetic effect (β), bonding parameter (b1/2) and Sinha’s parameter (δ %) are calculated. TGA and DTA results of [Pt (C24H16 FeI2N2O2).2H2O] and [Pd (C24H16 FeI2N2O2).2H2O] are reported, Complexes were losing weight due to exothermic and endothermic process. The mass spectra of prepared ligand (C24H18 FeI2 N2O2) and its complex such as [Mn (C24H16FeI2N2O2).2H2O] were used to compare their stoichiometric composition and it found that near about equal to the theoretical mass of the complex and prepared ligand. Synthesis of nanoparticles of OMNPs (organometallic Nanoparticles) of Cu(II) Complex with SEM and EDX were...
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Posted by admin on Jul 31, 2017 in |
Hypothyroidism is a common disorder of endocrine system in which the thyroid gland does not produce enough thyroid hormone. The most common cause of hypothyroidism is inflammation of the thyroid gland, which damages the gland’s cells. It can affect growth, cellular processes and many other body functions. As more damage accumulates, the risk of Hypothyroidism increases. In order to make an impact on Hypothyroidism, we must understand the molecular processes and structure-function relationships of TSH permitted better understanding of the role of specific protein and carbohydrate domains in the synthesis, bioactivity, and clearance of this hormone. Thyroid hormone receptor alfa-1 (THRA1) is an endocrine nuclear receptor that mediates the transcriptional effects of thyroid hormone (triiodothyronine, T3). It acts as an agonist i.e. it stimulates the production of thyroid hormone by triggering a response in the cell, which is selected as target protein. The primary goal of the project was to unearth natural chemical compounds that can be used as an agonist (increase thyroid hormone level in patients) for the...
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Posted by admin on Jul 31, 2017 in |
A new series of Cu(II), Zn(II) and Co(II) complexes have been synthesized from 6-Methoxy-3-phenyliminomethyl-chromen-4-one, a Schiff base derived from 6-Methoxy-4-oxo-4H-chromene-3-carbaldehyde and aniline. The nature of bonding and the structure of the complexes have been deduced from IR, UV, 1H NMR spectroscopy. The biological activity of the ligand and metal complexes have been examined against both gram-positive as well as gram-negative bacteria by the Agar well method using DMSO as solvent and Gentamicin as standard drug. The zone of inhibition values and MIC were measured at 37 ºC for 24 h. Antimicrobial screening tests displayed better results for the metal complexes as compared to the...
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Posted by admin on Jul 31, 2017 in |
The aim of the present study is to screen the phytochemicals present in the leaf extract of Kandelia candel and further analysis of the bioactive components present in it by Gas chromatography – Mass spectrometry (GC-MS) analysis. Carbohydrates, proteins, amino acids, Saponins, flavonoids, terpenoids, glycosides, tannins, alkaloids, and phenols were present in the sample. The percentage yield of plant extract is high in ethanol extract and is 7.02%. GC-MS analysis of chloroform extract of K.candel leaf extract revealed the presence of 16 compounds and Longipinene epoxide(peak area 25.12) and 2-C14H26 (peak area 25.12)were the major compounds. The compounds were identified by comparing their retention time, peak area and by interpretation of mass spectra and matched with the National Institute of Standards and Technology (NIST)...
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Posted by admin on Jul 31, 2017 in |
Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, followed by stem, primarily by aqueous and methanolic extracts. The methanol and ethyl acetate extracts from all four plant parts showed decent antioxidant activities against DPPH free radicals, with methanolic extract of N. arbor-tristis stem showed activity as 86.9%, higher than the positive control. All the ethyl acetate extracts showed moderate to good activity (50-65%), showing that all the four plant parts have decent antioxidant potential. Further, the scavenging of the peroxide free radicals, produced during lipid per oxidation was also investigated. The methanolic extracts of flower and root, and ethyl acetate extract of stem showed almost 80% activity. The aqueous extract of leaf showed very good peroxide scavenging activity. The hexane extract...
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