Posted by admin on Jul 31, 2017 in |
The present study aims to synthesize 2-azetidinone derivatives; 4-(3-chloro-1-(4-substituted-phenyl)-4-oxoazetidin-2-yl)-2-methoxyphenyl-acetate (c1-c6) and 2-allyl-4-(3-chloro-1-(4-Substituted-phenyl)-4-oxoazetidin-2-yl)-6-methoxyphenyl4-methylbenzenesulfonate (d1-d6) by electrocyclisation of imines with chloroacetylchloride in the presence of triethyle – amine and 1, 4-dioxane. The synthesized compounds were characterized by FT-IR, 1H NMR spectra and elemental analysis and were screened in-vitro against three bacterial strains namely Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and two fungal strains namely Aspergillus niger, Aspergillus flavus by disc diffusion method. The compounds exhibited good antimicrobial activity....
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Posted by admin on Jul 31, 2017 in |
The lanthanide (III) complexes of general formula of [Ln(FPNH)2(NO3)](NO3)2.nH2O (where, Ln = La, Ce, Pr, Nd, Sm; FPNH = 2-formylpyridine nicotinoylhydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscopy. Molar conductivity data suggest that the complexes are 1:2 electrolytes. IR spectral data suggest that FPNH acts as neutral tridentate ligand. Spectral data of complexes suggest that the ligand binds metal ion through pyridine nitrogen, azomethine-nitrogen and amido-oxygen donor atoms. Electrochemical behaviour of metal complexes was investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one electron reduction. The binding interaction of complexes with CT-DNA was investigated using absorption spectrophotometry. Based on spectral changes, groove binding of complexes to DNA is...
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Posted by admin on Jul 31, 2017 in |
Synthesis of a Derivatives of imidazo[1,2-a]pyridines with potent activity. Synthetic approaches allowing for variation of the 2-Amino Pyridines as well as other imidazopyridine substituents are outlined and resulting effects on anticonvulsant activity are highlighted. An experimental evaluation of anticonvulsant activity of synthesized Imidazo[1,2-a]pyridine derivatives by Maximal Electro Shock (MES) induce...
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Posted by admin on Jul 31, 2017 in |
This study explored self-reported chronic illnesses and use of prescription medicines (PM) by elderly Malays in the community. The study was a population based cross sectional study conducted among 490 Malay subjects aged ≥ 60 years in the semi-urban and rural areas in Perak, Malaysia. The study was conducted using pre-validated questionnaires after getting informed consent from the study participants. Critically ill and subjects with cognitive impairment were excluded from the study. The mean age of the elderly respondents was 69.7 years and 68.4% of the elderly were females. Respondents belonging to the age group 60-69 years constituted the largest group (54.5%). The most common illness reported was hypertension (59.8%) followed by hypercholesterolemia (42.7%) and diabetes mellitus (32.2%). Other chronic illnesses were osteoarthritis (6.3%), bronchial asthma (4.1%), other cardiovascular diseases (2.2%) and other diseases (19.2%). 52.9% of elderly study subjects had multiple illnesses. 76.7% used at least one prescription medication. The highest users of PM were aged between 70-79 years, while the lowest users of PM were ≥ 80...
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Posted by admin on Jul 31, 2017 in |
Home based education among clients with diabetes mellitus (DM) by diabetes educator has been cost effective although some educational intervention have strong evidence on cost saving. This study aimed to assess the cost effectiveness of home based education programme on diabetic treatment among clients with diabetes mellitus. Community based randomized controlled trial with experimental design was used in this study. Diabetic subjects who had been undergoing treatment for 3 months in Marai Malai Nagar and 9 villages at Mamandoor were selected by simple random sampling technique. 200 Participants were assigned to the study group, 200 in control group. The study group subjects were engaged in video education program, weekly once 4 sessions and nutritional counseling every 15days 30 mins for 3 months. The overall post interventional result showed from the baseline compared to control group, there was an absolute mean change in direct medical cost (from Rs 2837.05 to 1674.65), cost of investigation (from Rs 319.50 to Rs 261.11), non medical cost (from Rs 369.87 to Rs 110.79), indirect...
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