Posted by admin on Jul 31, 2017 in |
The main aim of this study was to develop Mebeverine colon specific drug delivery system with increased stability of drug in stomach and small intestine. This stability of drug was achieved by coating of the drug core with Chitosan and Ethyl cellulose polymers by direct compression using tablet punching machine. Mebeverine was a drug whose therapeutic role is in the treatment of Irritable Bowel Syndrome and the associated abdominal cramping. It works by relaxing the muscle in and around the gut. It was a musculotropic antispasmodic drug without having anticholinergic side effects. The drug is also indicated for gastrointestinal spasm secondary organic disorder. The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This study, mainly compares the primary approaches for Colon Specific Drug Delivery namely prodrugs, pH and time dependent systems,...
Read More
Posted by admin on Jul 31, 2017 in |
There are various treatment regimens including different antibiotics and antacid medications for eradicating Helicobacter pylori to compare the effectiveness of 7-day concomitant regime with classic triple regimen in eradicating H. pylori. In this randomized clinical trial, 206 dyspeptic patients proven H. pylori infection, attended to a gastrointestinal clinic in Khorramabad (west of Iran) were studied. The patients were randomly divided in two equal groups. Classic group were treated for 14 days with a regimen including omeprazole 20mg, amoxicillin 1g and clarithromycin 500mg, twice daily. In concomitant group, the patients were treated for 7 days with a regimen including omeprazole 20mg, amoxicillin 1g, clarithromycin 500mg and metronidazole 500mg twice daily. During the treatment period and a week after the end of treatment, the patients were evaluated in terms of possible side-effects and medication acceptance and tolerance. For confirmation of eradication, 6 weeks after the end of treatment, urea breath test with carbon 13 (UBT) was done for both the groups. Data were analyzed using descriptive statistics, T-test and chi-square test,...
Read More
Posted by admin on Jul 31, 2017 in |
Porphyrins are ever-present large class of naturally occurring macrocyclic compounds with many significant biological representatives comprising heme and chlorophyll. Novel bi-metallic porphyrins derived from [5-(4-hydroxyphenyl)-10,15,20-tri(4-methyl phenyl) porphyrin] and salicylideneamino-2-(N,N-dimethylamino) ethane copper (II) perchlorate was obtained in good yields. The results from various physico-chemical studies reveal a change in the geometry of the copper environment after coordination at the periphery of the porphyrin. The EPR of monocuperated metalloporphyrins have signals of copper with planar geometry and lacks the lines corresponding to peripheral metal due to dipolar broadening. Weak interaction between the metal centers is clear from nickel...
Read More
Posted by admin on Jul 31, 2017 in |
Objective: The present study was conducted to assess the incidence, causality and severity of diuretic induced Adverse Drug Reactions (ADRs). Method: 92 patients admitted in the intensive cardiac care unit and prescribed with diuretics were included and data on demographics, past medical and medication history, allergies to food/drugs, laboratory parameters, diuretics prescribed, side effects and ADRs were obtained. The causality of ADRs was assessed using Naranjo’s and WHO’s a causality assessment scale, the severity of ADRs using Hartwig and Siegel’s scale. Results: 41 (44.6%) patients were prescribed with one diuretic, 38(41.3%) with 2 diuretics and 13 (14.1%) with 3 diuretics. 54 patients were prescribed with loop diuretics, a combination of loop and potassium sparing diuretics were given for32 patients; loop and thiazides for 5 and a potassium sparing diuretic for one patient. Of 40 (44%) patients with ADRs, 32 had one ADR, 7 had two ADRs and one patient had three ADRs. Naranjo’s scale identified 25 ADRs as probable, 15 as Possible and none as unlikely or certain; WHO...
Read More
Posted by admin on Jul 31, 2017 in |
Protein conformation and dynamics are influenced by various factors, including binding of ligands, their physico-chemical properties, etc. Every conformational change is dictated by an array of events, as making and breaking of bonds or change in interaction of protein residues. The three dimensional structure of protein molecules are widely investigated, based on small world network approaches, with an emphasis on different combinations of descriptors affecting the structure which have been tested on studies involving binding in protein ligand complexes and for protein-protein complexes. This application has revealed the benefits and success of the small world network approach which can change the focus from specific interactions in the local environment or to non-local phenomenon. Network analysis of interacting protein upon ligand binding is analysed. A similarity in interaction parameters among residues of the target protein, upon binding of particular ligands, is identified. This method differentiates ligands, on the basis of overall changes in interaction among residues of Target proteins in...
Read More
